Antiinflamatory Flashcards
what is the amount of prednisone equivalent to our normal body cortisol
5mg which is equal to our 20mg
How is fever regulated
Prostaglandins released via hypothalamus
whats the length of time a pt needs to be on corticosteroids that requires a taper withdrawal
2 weeks
what are the 5 classic clinical sings of inflammation
red, pain, swelling, heat, and impaired function
which step in the inflammatory process does prednisone actually act upon
inhibits phospholipase; makes it better for stopping/control of inflammation than COX cause its earlier on in the process.
What is a side effect that is of great concern with steroids/prednisone
depressed immune system (latent TB, other diseases)
What are some other antiinflammatories
tetracylince and macrolides
why is the HPA system of great concern with long term use prednisone
may suppress HPA and that affects all parts of body
What acute phase proteins are often measured to determine how treatment is affecting inflammation
C-reactive protein, serum amyloid A
and Erythoctye sedimentation rate
Describe ESR
fibrinogen binds to erythrocyte, making them stack and more denser
This is made by the liver and act to promote phagocytic activity, trap invading microbes in blood clots, prevent microbes from uptaking iron. They are measured as an indication for inflammation and how your rx is working
acute phase proteins (C reactive proteins, serum amyloid A) and ESR
Which cells would be recruited to attack viruses
cytotoxic cells (CD8)
which cells would be elevated with bacterial
neutrophils
whats the main difference btw acute and chronic inflammation?
cells involved, macrophages in chronic. Neutrophils in acute
Chronic inflammation often has a distinctive pattern called granulomatous. describe this:
macrophages aggregate to wall-off and isolate foreign material/debris
