Antiemetic & Antinausea Flashcards
Types of antiemetic & anti nausea drugs
-anticholinergic drugs
-antihistamines (histamin 1 receptor blockers)
-antidopaminergic
-neurokinin antagonist
-prokinetic
-serotonin blockers
-tetrahydrocannabinoids
Main anticholinergic drug
Scopolamine bromide
Site of action of scopolamine
Inner ear labyrinth
Main antihistamine drugs
Dimenhydrinate (Gravol)
Diphenhydramine (Benadryl)
Dimenhydrinate & diphenhydramine indication
Motion sickness, nonproductive cough, allergy symptoms, sedation
Main antidopaminergic drugs
Prochlorperazine (Proclorazine)
Prochlorperazine indication
Psychotic disorders, intractable hiccups in chemotherapy
Main neurokinin receptor antagonist
Aprepitant (Emend)
Aprepitant indication
Inhibit acute & delayed phases of chemotherapy-induced emesis
Main prokinetic drugs
Metoclopramide (Metonia)
Metoclopramide indication
GI reflux, delayed GI emptying (stimulates peristalsis = enhance stomach emptying)
Adverse effect of metoclopramide form long term use
Irreversible tardive dyskinesia*
Main serotonin blocker
Ondansetron (Zofran)
Ondansetron indication
Nausea & emesis in chemotherapy and postop
Main drug for tetrahydrocannabinoids
Medical marihuana