Adrenergic drugs

Question 1

Adrenergic Blockers

Answer 1

Bind to adrenergic receptors but inhibit or block stimulation of the sympathetic nervous system (SNS)
Have the opposite effect of adrenergic drugs
Inhibit (lyse) sympathetic stimulation

Question 2

Adrenergic Blockers are also known as?

Answer 2

• Adrenergic antagonists
• Sympatholytics
• α-blockers, β-blockers, and α-β–blockers

Question 3

Adrenergic Blockers, Classified by the type of adrenergic receptor they block what?

Answer 3

α1- and α2-receptors, β1- and β2-receptors

Question 4

Drug Effects and Indications: a-Blockers, does what?

Answer 4

Cause both arterial and venous dilation, reducing peripheral vascular resistance and blood pressure (BP)

Question 5

Drug Effects and Indications: a-blockers, are used to treat what?

Answer 5

Used to treat hypertension

Question 6

Drug Effects and Indications: a-blockers, effect on the receptors?

Answer 6

Effect on receptors on the prostate gland and bladder decreases resistance to urinary outflow, thus reducing urinary obstruction and relieving the effects of benign prostatic hyperplasia (BPH).

Question 7

Drug Effects and Indications: a-blockers (Phentolamine) does what?

Answer 7

Quickly reverses the potent vasoconstrictive effects of extravasated vasopressors such as norepinephrine or epinephrine
Restores blood flow and prevents tissue necrosis

Question 8

α-Blockers: Adverse Effects, on the cardiovascular?

Answer 8

Palpitations, orthostatichypotension, tachycardia, edema, chest pain

Question 9

a-blockers adverse effects on the, Central nervous system?

Answer 9

Dizziness, headache, anxiety, depression, weakness, numbness, fatigue

Question 10

α-Blockers: Adverse Effects, GI?

Answer 10

Nausea, vomiting, diarrhea, constipation, abdominal pain

Question 11

α-Blockers: Adverse Effects, other?

Answer 11

Incontinence, dry mouth, pharyngitis

Question 12

what are common a-blockers?

Answer 12

• phentolamine mesylate (Rogitine®)
• tamsulosin (Flomax®)

Question 13

phentolamine (Rogitine®), what does it do?

Answer 13

α-Blocker that reduces systemic vascular resistance and is sometimes used to treat hypertension

Question 14

phentolamine (Rogitine®), most commonly used to treat what?

Answer 14

Most commonly used to treat the extravasation of vasoconstricting drugs such as norepinephrine, epinephrine, and dopamine

Question 15

tamsulosin (Flomax®) is primarily used to treat what?

Answer 15

α-Blocker used primarily to treat BPH; exclusively indicated for male patients

Question 16

Tamsulosin contraindication?

Answer 16

known drug allergy and concurrent use of erectile dysfunction drugs such as sildenafil

Question 17

Tamsulosin adverse effects?

Answer 17

headache, abnormal ejaculation, rhinitis, and others

Question 18

what does b-blockers compete with?

Answer 18

norepinephrine and epinephrine

Question 19

β-Blockers, can be?

Answer 19

Can be selective or nonselective
Cardioselective β-blockers or β1-blocking drugs
Nonselective β-blockers block both β1-receptors and β2-receptors.

Question 20

β2-Receptors are located primarily on what?

Answer 20

on the smooth muscles of the bronchioles and blood vessels.

Question 21

Intrinsic Sympathomimetic Activity (carvedilol, labetalol) does what?

Answer 21

α-Receptor–blocking activity, especially at higher dosages