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PHARM > anti-inflammatory and antigout > Flashcards

anti-inflammatory and antigout Flashcards

1
Q

t/f
Inflammation is a systemic response to injury that affects the entire body.

A

f

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2
Q

t/f
NSAIDs inhibit the leukotriene pathway exclusively.

A

f

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3
Q

t/f
Aspirin has been shown to reduce cardiac death after myocardial infarction.

A

t

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4
Q

t/f
All NSAIDs have both analgesic and anti-inflammatory properties

A

t

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5
Q

NSAIDs should be administered at the first sign of myocardial infarction.

A

f

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6
Q

What are the properties shared by all NSAIDs?
a) Antipyretic properties
b) Antibiotic properties
c) Antihypertensive properties
d) Antifungal properties

A

a

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7
Q

Which of the following is NOT a use of NSAIDs?
a) Relief of postoperative pain
b) Treatment of bacterial infections
c) Relief of pain associated with arthritic disorders
d) Treatment of gout and hyperuricemia

A

b

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8
Q

What is the main mechanism of action of NSAIDs?
a) Inhibition of leukotriene pathway
b) Inhibition of COX enzyme
c) Inhibition of histamine release
d) Activation of prostaglandin synthesis

A

b

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9
Q

Which NSAID is known to specifically inhibit COX-2?
a) Celecoxib
b) Ibuprofen
c) Naproxen
d) Aspirin

A

a

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10
Q

SATA
Uses of NSAIDs include:
a) Relief of mild to moderate headaches
b) Treatment of bacterial infections
c) Relief of myalgia
d) Treatment of hypertension e) Relief of postoperative pain f) Treatment of gout and hyperuricemia

A

a,c,e,f

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11
Q

SATA
Properties shared by all NSAIDs include:
a) Antipyretic properties
b) Antibiotic properties
c) Anti-inflammatory properties
d) Antifungal properties

A

a,c

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12
Q

t/f
Aspirin is an irreversible inhibitor of COX-2 receptors within platelets.

A

f

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13
Q

NSAIDs cause an increased risk of serious gastrointestinal adverse events.

A

t

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14
Q

NSAIDs are contraindicated in conditions that place the patient at risk for bleeding.

A

t

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15
Q

Salicylates, such as aspirin, are commonly available in rectal suppository form.

A

t

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16
Q

NSAIDs can precipitate acute or chronic kidney injury or failure by enhancing prostaglandin function.

A

f

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17
Q

What is the main mechanism of action of aspirin in inhibiting platelet aggregation?
a) Inhibition of COX-2 receptors
b) Inhibition of thromboxane A2 formation
c) Stimulation of prostaglandin synthesis
d) Inhibition of prostacyclin production

A

b

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18
Q

What is the primary form of salicylate used for prophylactic therapy to prevent thrombotic events?
a) Oral tablets
b) Rectal suppositories
c) Intravenous infusion
d) Topical cream

A

a

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19
Q

Which adverse effect is NOT associated with salicylate intoxication?
a) Increased heart rate
b) Drowsiness
c) Hyperglycemia
d) Nausea and vomiting

A

c

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20
Q

SATA
9. What are uses of aspirin?
a) Relief of headache
b) Treatment of bacterial infections
c) Relief of pain associated with inflammation
d) Prophylactic therapy for thrombotic events
e) Treatment of systemic lupus erythematosus

A

a,c,d

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21
Q

SATA
What are contraindications for NSAID use?
a) Rhinitis
b) Known drug allergy
c) Vitamin K deficiency
d) Peptic ulcer disease
e) Conditions that place the patient at risk for bleeding

A

b,e

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22
Q

Which statement is true about NSAIDs?
a) All NSAIDs have antiplatelet effects
b) NSAIDs do not affect kidney function
c) NSAIDs increase the risk of adverse cardiovascular thrombotic events
d) NSAIDs are safe for use in older adults

A

c

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23
Q

Which of the following is a known adverse effect of NSAIDs?
a) Bradycardia
b) Hypertension
c) Noncardiogenic pulmonary edema
d) Hypoglycemia

A

c

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24
Q

What is the primary mechanism of action of misoprostol in preventing gastrointestinal bleeds associated with NSAID use?
a) Inhibiting COX-2 receptors
b) Stimulating prostaglandin synthesis
c) Enhancing thromboxane A2 formation
d) Inhibiting platelet aggregation

A

b

25
Q

Which of the following is a use of misoprostol?
a) Treatment of bacterial infections
b) Relief of headache
c) Prevention of gastrointestinal bleeds associated with NSAID use
d) Relief of myalgia

A

c

26
Q

What is Reye’s syndrome primarily triggered by?
a) Allergic reactions
b) Salicylate therapy in the presence of a viral illness
c) Overdose of NSAIDs
d) Bacterial infections

A

b

27
Q

Which of the following NSAIDs is also known as an antiplatelet agent?
a) Celecoxib
b) Ibuprofen
c) Naproxen
d) Aspirin

A

d

28
Q

What is the primary form of aspirin used for prophylactic therapy for adults at risk of thrombotic events?
a) Enteric-coated tablets
b) Topical cream
c) Rectal suppositories
d) Intravenous infusion

A

a

29
Q

What is the primary adverse effect associated with salicylate intoxication?
a) Tinnitus
b) Hyperglycemia
c) Bradycardia
d) Hyperventilation

A

a

30
Q

Which of the following is a use of aspirin in systemic lupus erythematosus?
a) Relief of myalgia
b) Reduction of fever
c) Antirheumatic effects
d) Prevention of bacterial infections

A

c

31
Q

Which of the following is a potential adverse effect of aspirin therapy in patients with Reye’s syndrome?

a) Hypoglycemia
b) Hyperglycemia
c) Cardiac arrhythmias
d) Seizures

A

d

32
Q

t/f
Indomethacin is primarily used for its antiplatelet effects.

A

f

33
Q

t/f
Naproxen has a higher incidence of adverse effects compared to ibuprofen.

A

f

34
Q

t/f
Celecoxib has little effect on platelet function.

A

t

35
Q

t/f
Misoprostol can be used to reduce gastrointestinal bleeding associated with NSAID use.

A

t

36
Q
A
37
Q

t/f
Gout is a condition resulting from overproduction of urea.

A

f

38
Q

What is the primary indication for ketorolac tromethamine (Toradol)?
a) Long-term management of rheumatoid arthritis
b) Short-term management of acute pain
c) Prevention of gouty arthritis
d) Treatment of systemic lupus erythematosus

A

b

39
Q

Which NSAID is the first and only remaining COX-2 inhibitor?
a) Ibuprofen
b) Naproxen
c) Celecoxib
d) Piroxicam

A

c

40
Q

What is the primary adverse effect associated with NSAIDs on the renal system?
a) Hypokalemia
b) Acute tubular necrosis
c) Bradycardia
d) Hypertension

A

b

41
Q

Which drugs can cause serious interactions when given with NSAIDs?
a) Anticoagulants
b) Antihistamines
c) Antidepressants
d) Antidiabetic medications

A

a

42
Q

SATA
What are uses of indomethacin? - a) Treatment of rheumatoid arthritis
b) Treatment of osteoarthritis
c) Treatment of acute gouty arthritis
d) Prevention of malaria

A

a) Treatment of rheumatoid arthritis, b) Treatment of osteoarthritis, c) Treatment of acute gouty arthritis

43
Q

SATA
Which drugs can cause serious interactions when given with NSAIDs?
a) Alcohol
b) Antacids
c) Antihypertensives
d) Antipsychotics

A

a) Alcohol, c) Anticoagulants, e) Corticosteroids and other ulcerogenic medications

44
Q

t/f
Allopurinol is primarily used to increase uric acid production.

A

f

45
Q

t/f
Probenecid increases the reabsorption of uric acid in the kidneys.

A

f

46
Q

t/f
Colchicine is the oldest available therapy for gout.

A

t

47
Q

t/f
Glucosamine and chondroitin are herbal products commonly used to treat hypertension.

A

f

48
Q

t/f
Salicylates should be given to children and teenagers without any concerns.

A

f

49
Q

What is the primary indication for allopurinol (Zyloprim)?
a) Treatment of hypertension
b) Prevention of uric acid production
c) Treatment of acute tumour lysis syndrome
d) Prevention of malaria

A

b

50
Q

What is the mechanism of action of probenecid (Benuryl)?
a) Increases reabsorption of uric acid in the kidneys
b) Inhibits the reabsorption of uric acid in the kidneys
c) Stimulates uric acid production in the liver
d) Inhibits the formation of uric acid crystals in the joints

A

b

51
Q

What is the primary adverse effect of colchicine?
a) Exfoliative dermatitis
b) Stevens-Johnson syndrome
c) Leukopenia
d) Drowsiness

A

c

52
Q

What is the primary indication for glucosamine and chondroitin?
a) Treatment of hypertension
b) Treatment of osteoarthritis pain
c) Prevention of malaria
d) Treatment of acute gouty arthritis

A

b

53
Q

Select all that apply
What are potential nursing implications for patients receiving NSAIDs?
a) Observe for GI lesions or peptic ulcer disease
b) Monitor for bleeding disorders
c) Perform laboratory studies such as cardiac, kidney, and liver function tests
d) Administer salicylates to children and teenagers
e) Educate patients about the various adverse effects of NSAIDs

A

a,b,c,e

54
Q

What is the main adverse effect associated with allopurinol (Zyloprim)?
a) GI bleeding
b) Exfoliative dermatitis
c) Renal impairment
d) Bradycardia

A

b

55
Q

How does colchicine primarily work to manage gout?
a) By inhibiting uric acid production
b) By promoting uric acid excretion
c) By reducing inflammation associated with uric acid crystal deposition
d) By increasing the synthesis of uric acid

A

c

56
Q

What is the primary indication for febuxostat (Uloric®)?
a) Treatment of acute pain
b) Prevention of uric acid production
c) Treatment of acute tumour lysis syndrome
d) Prevention of gout flares

A

d

57
Q

What is the primary mechanism of action of probenecid (Benuryl)?
a) Inhibiting uric acid synthesis
b) Increasing uric acid reabsorption in the kidneys
c) Inhibiting uric acid reabsorption in the kidneys
d) Promoting uric acid excretion in the kidneys

A

d

58
Q

Which of the following is NOT a potential adverse effect of glucosamine?
a) GI discomfort
b) Drowsiness
c) Headache
d) Skin reactions

A

b

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