Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

PHARM > Acid-Controlling Drugs > Flashcards

Acid-Controlling Drugs Flashcards

1
Q

Types of food & factors that stimulate parietal cell secretion of HCI

A

Caffeine, chocolate, fatty food, alcohol, emotional stress

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Treatment for H. Pylori

A

-triple therapy (7-14 day course of PPI, clarithromycin, and either amoxicillin or metronidazole)
-quadruple therapy (PPI, bismuth subsalicylate, tetracycline, metronidazole)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Type of drug given to prevent stress-related mucosal damage

A

Histamine receptor-blocking drug or PPI

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Types of Acid-controlling drugs

A

Antacids, H2 antagonist, PPI

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

T/F: Antacids inhibit acid secretion

A

False- only neutralizes acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Antiflatulent drug

A

Simethicone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Why is magnesium used with some aluminum and calcium based antacids

A

Counteracts constipating effects of aluminum and calcium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Calcium antacids adverse effect

A

Kidney stones, increase gastric acid secretion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Magnesium based antacids contraindications

A

Renal failure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Sodium bicarbonate onset & duration

A

Quick onset, short duration of action

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Antacid indication

A

Peptic ulcer, gastritis, gastric hyperacidity, heartburn

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Antacid contraindications

A

Severe renal failure, electrolyte disturbance, GI obstruction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Local antacid anesthetic

A

Mucaine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Aluminum salts adverse effects

A

constipation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Type of antacid recommended for patients with renal disease

A

Aluminum salts; easy excretion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Aluminum salts examples

A

Combination products (aluminum and magnesium): Antacid Plus, Diovol, Gelusil, Maalox, Multiaction

Highlight in red in slides; just take note of it, but may not show up in final

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Magnesium salts adverse effect

A

Diarrhea

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Magnesium salts examples

A

Magnesium hydroxide and mineral oil (Magnolox)

Red in slides, but may not show up on final

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Calcium salts adverse effects

A

Kidney stones, constipation, hyperacidity rebound*

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Calcium salts contraindication

A

Renal disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Calcium salts examples

A

Calcium carbonate and simethicone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Sodium bicarbonate adverse effects

A

Metabolic alkalosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Sodium bicarbonate contraindication

A

HF, hypertension, renal insufficiency

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Calcium bicarbonate adverse effect

A

Flatulence

22
Q

H2 Receptor Antagonist drugs

A

ranitidine hydrochloride
famotidine

23
Q

H2 receptor antagonist MOA

A

Suppressed acid stomach secretion

24
Q

H2 receptor antagonist indication

A

GERD, peptic ulcer disease, erosive esophagitis, upper GI bleeding, Zollinger-Ellison syndrome, stress ulcer prophylaxis

25
Q

H2 receptor antagonist adverse effects in older populations

A

confusion, disorientation

26
Q

Ranitidine hydrochloride & famotidine adverse effects

A

thrombocytopenia

27
Q

Ranitidine & famotidine interactions

A

-Inhibit absorption for drugs requiring an acidic GI envy’ for absorption
-reduced effectiveness when smoking

28
Q

When taking with antacids, when should you take ranitidine and famotidine

A

1-2 hr before antacids

29
Q

PPI difference from H2 antagonist and antacids

A

PPI is complete HCI secretion blockage. Other two are partial blockage

30
Q

Which one is stronger: H2 antagonist or antacids

A

H2 antagonist

31
Q

PPI examples

A

Lansoprazole, omeprazole, pantoprazole sodium

32
Q

Pantoprazole route

A

IV only

33
Q

Define achlorhydria & its indication

A

temporary state of complete gastric acid secretion blockage, but does not affect food absorption
-good for ulcers

34
Q

PPI indication

A

GI reflux, erosive esophagitis, short term treatment for active duodenal and benign gastric ulcers, Zollinger-Ellison, NSAIDs ulcers, stress ulcer prophylaxis, H. pylori induced infections

35
Q

What to give with PPI for NSAIDs induced ulcers

A

Food

36
Q

PPI adverse effects

A

osteoporosis, C. diff risk, pneumonia, fractures, Mg depletion

37
Q

PPI adverse effects in older population

A

increased risk of acute kidney injury, interstitial nephritis

38
Q

PPI interactions

A

Diazepam and phenytoin: increased serum levels of other drug
Warfarin: bleeding
Ketoconazole, ampicillin, iron salts, digoxin: increased absorption of other drug
Copidogrel: MI risk, death
Sucralfate: delayed absorption of PPI
Food: PPI decreased absorption

39
Q

When to take PPIs

A

Before breakfast to increase effectiveness; 1 hr before meals

40
Q

Miscellaneous acid-controlling drugs

A

sucralfate, misoprostol, simethicone

41
Q

sucralfate indication

A

stress ulcers, peptic ulcer disease

42
Q

sucralfate adverse effect

A

constipation*, dry mouth, nausea

43
Q

when to take sucralfate

A

2 hr before other drugs on empty stomach

44
Q

Sucralfate frequency consideration

A

Short half life; impractical – have to take often

45
Q

Sucralfate interactions

A

Phosphate: decreased phosphate level; used in chronic renal failure

46
Q

T/F: Sucralfate acts systemically

A

False

47
Q

Misoprostol indication

A

prevent NSAIDS induced gastric ulcers

48
Q

what time in the day to take misoprostol

A

at bedtime, with meals

49
Q

High dose of misoprostol indication

A

abortion medication– stimulates contractions

50
Q

misoprostol adverse effects

A

diarrhea, abdominal cramps

51
Q

When should you take antacids when taking other medications

A

admin antacids within 1-2 hr of other meds

52
Q

How much water to drink with antacids to increase absorption

A

at least 240 mL

53
Q

Adverse effects of long term antacid use

A

Mask underlying disease: malignancy, bleeding ulcers

54
Q

T/F: Pantoprazole capsule granules should not used via NG tubes

A

False. They can be used and mixed with apple juice, but not chewed or crushed

55
Q
A

PHARM (20 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions