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Pharmacology 2 > Anti-Virals > Flashcards

Anti-Virals Flashcards

1
Q

which drug is a pyrimidine nucleoside

A

trifluridine

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2
Q

what is trifluridine used to treat

A

herpetic keratitis

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3
Q

what are the adverse effects of trifluridine

A

discomfort
palpebral edema

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4
Q

which purine nucleoside is topically applied for ocular herpesvirus

A

vadarabine

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5
Q

what is the main use of vadarabine

A

acyclovir resistant herpes

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6
Q

true or false:

vidarabine is helpful when treating all resistant herpes

A

false
it only inhibits DNA viruses

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7
Q

how is vidarabine eliminated from the body

A

urine

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8
Q

which drugs have better efficacy when phosphorylated to triphosphate

A

acyclovir
valacyclovir

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9
Q

true or false:

acyclovir and valacyclovir are unable to eliminate latent infections

A

true

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10
Q

how are acyclovir and valacyclovir eliminated from the body

A

unchanged by glomerular filtration

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11
Q

true or false:

it is best to give acyclovir and valacyclovir orally

A

false
low oral bioavailability

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12
Q

what is ribavirin used for in cats

A

FELV
FIV
calicivirus
coronavirus

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13
Q

what is ribavirin used for in dogs

A

distemper
parainfluenza

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14
Q

what are the main toxicities with ribavirin

A

cats - bone marrow
dogs - hepatotoxicity

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15
Q

which drug is not approved for BLV

A

zidovudine

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16
Q

true or false:
it is fine to give zidovudine orally

A

true
high oral bioavailability

17
Q

what species is zidovudine used in

A

cats
bovine*

18
Q

what are the adverse effects of using zidovudine in cats

A

progressive anemia and neutropenia

19
Q

which drug has a narrow range of activity against viruses but also can be used for pain treatment

A

amantadine

20
Q

what is the main indication of use of amantadine

A

equine influenza

21
Q

how is amantadine eliminated from the body

A

unchanged renally

22
Q

which interferon anti-virl is used for parvo, FIV and FeLV

A

interferon omega

23
Q

what is the main use of Type 1 interferon

A

herpes
calicivirus
stress induced diseases

24
Q

what species is Type 1 interferon used in

A

dogs
cats
cattle
pigs
horses

25
Q

what species is interferon omega used in

A

dogs
cats

Pharmacology 2 (11 decks)

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