Anti-Cancer Flashcards
which drugs are nitrogen mustards
chlorambucil
cyclophosphamide
melphalan
which nitrogen mustard is used for chronic lymphocytic leukemia and mast cells
chorambucil
in what species would you want to combine chlorambucil with sterioids
cats
what drug should be used for GI lymphoma in cats
chlorambucil
a cat comes in with a loss of whiskers. which drug was he probable on
chlorambucil
what cytotoxic agent causes sterile hemorrhagic cysts
acrolein
cyclophosphamide
what drug is used to treat the sterile hemorrhagic cyst
furosemide
hwo does chlorambucil affect tumor growth
slows them down
what is needed to convery cyclophosphamide to its active form
cyclophosphamide
what is cycylophosphamide used to treat in cats
lymphoma
what is cyclophosphamide used to treat in dogs
lymphoma
malignant mammary gland tumors
what are the adverse effects shared by chlorambucil and cyclophosphamide
GI toxicity in cats
alopecia
myelosuppression
neutropenia
thrombocytopenia
what nitrogen mustard is used as a rescue drug to treat relapsed lymphoma dogs
melphalan
what is the adverse effect of melphalan
delayed thrombocytopenia
which nitrosoureas drug crosses the blood brain barrier
lomustine
what are the adverse effects of lomustine
bone marrow depression
hepatotoxicity
what is the main use of lomustine due to its ability to cross the blood brain barrier
brain tumors
other than brain tumors, what else can lomustine be used for
histiocytic sarcomas
mast cells
epitheliotropic and refractory lymphomas
which drugs are platinum compounds
cisplatin
carboplatin
what is downfall of the platinum compounds
resistance to the drugs can occur through inactivation and increased repair
how are the platinum compounds administered
IV
which platinum compound is combined with doxorubicin
carbplatin
which platinum compound is used for squamous cell carcinoma, osteosarcomas, transitional cell carinomas and nasal adenocarcinomas
cisplatin
what is carboplatin used for
canine appendicular osteosarcoma
carcinomas
in general what are the platinum compounds used for
carcinomas
what are some concerns to be aware of when administering cisplatin
nephrotoxicity
emesis
do not used in cats
what are some concerns to be aware of when administering carboplatin
myelosuppression
less nephrotoxicity and emesis
which drugs can be used to treat intracranial lymphomas and lymphoma and leukemia in combination
cytarabine
what can be combined with cytarabine to treat meningoencephalitis
prednisolone
how is cytarabine administered
SQ
CRI
what are the adverse effects of cytarabine
myelopsuppression
GI upset
which drug should be used to treat sarcoid in horses and spindle cell tumors in dogs
5-fluorouracil
how is 5-fluorouracil administered
local
topical
how does 5-fluorouracil affect dogs
myelosuppression
GI toxicity
neurotoxicity
in what species should 5-fluroruracil not be used in
cats
which drug can see resistance due to upregulation of MDR1
doxorubucin
mitoxantrone
how is doxorubucin administered
IV only
which drug is considered broad spectrum
doxorubicin
what dog breeds are contraindicated with doxorubicin due to worse cardiotoxicity
dobermans
boxers
what are the adverse effects of doxorubucin
myelosuppression
GI toxicity
cardiotoxicity
severe tissue necrosis
renal tubular damage in cats
acute anaphylaxis
what can be combine with doxorubicin
carboplatin
which drug is used for lymphomas
leukemias and transitional cell carcinoma of bladder
mitoxantrone
which cytotoxic antibiotic should not be used with radiotherapy
doxorubicin
mitoxantrone
why is mitoxantrone a better cytotoxic antibiotic
no cardiotoxicity or tissue necrosis
which drugs are plant derivatives
vincristine
vinbalstine
paclitaxel
which drugs see resisitance due to tubulin binding
vincristine
vinblastine
what is vinblastine used for in dogs
mast cell tumors
what is vincristine used for
lymphoma
TVT
what drugs cross resist with vincristine and vinblastine
doxorubicin
mitoxantrone
what is paclitaxel used for
osteosarcomas
mammary carcinomas
malignant histiocytomas
which antineoplastic drug has a rapidly developing resistance
L-asparaginase
what is L-asaparaginase used for
lymphoid malignancies
which drug is used for anal sac adenocarcinomas
toceranib
