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Maddy - First Aid > Anti-Lipid Pharm > Flashcards

Anti-Lipid Pharm Flashcards

1
Q

MOA statins

A

HMG CoA reductase inhibitors –> lowers cholesterol levels –> increases LDL receptors –> increase LDL recycling

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2
Q

do statins decrease mortality in CAD patients

A

YES

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3
Q

adverse effects statins

A

hepatotoxicity

myopathy (especially when used with fibrates)

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4
Q

MOA bile acid resins

A

prevent intestinal reabsorption of bile acids –> liver then has to use cholesterol to make more

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5
Q

adverse effects bile acid resins

A

GI upset

decrease absorption of other drugs and fat soluble vitamins

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6
Q

MOA ezetimibe

A

prevents cholesterol absorption at small intestine brush border

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7
Q

adverse effects ezetimibe

A

rare increase in LFTs

diarrhea

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8
Q

MOA fibrates

A

upregulate LPL –> increases triglyceride clearance

also activates PPAR-a to induce HDL synthesis

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9
Q

adverse effects fibrates

A

myopathy (increased risk with statins)

cholesterol gallstones (via inhibition of choelsterol 7a-hydroxylase)

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10
Q

MOA niacin

A

inhibits lipolysis in adipose tissue

reduces VLDL synthesis

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11
Q

adverse effects niacin

A

flushed face

hyperglycemia

hyperuricemia

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12
Q

MOA PCSK9 inhibitors

A

inactivation of LDL-receptor degradation –> increases removal of LDL from bloodstream

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13
Q

adverse effects PCSK9 inhibitors

A

myalgias

delirium

dementia

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14
Q

MOA fish oil and marine omega-3 fatty acids

A

believed to decrease FFA delivery to liver and decrease activity of TG-synthesizing enzymes

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15
Q

Statins

  • LDL levels
  • HDL levels
  • triglyceride levels
A
  • LDL levels:
  • HDL levels:
  • triglyceride levels:
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16
Q

Statins

  • LDL levels
  • HDL levels
  • triglyceride levels
A
  • LDL levels: VERY decreased
  • HDL levels: mild increase
  • triglyceride levels: mild decrease
17
Q

Bile acid resins

  • LDL levels
  • HDL levels
  • triglyceride levels
A
  • LDL levels: decreased
  • HDL levels: mild increase
  • triglyceride levels: mild increase
18
Q

Ezetimibe

  • LDL levels
  • HDL levels
  • triglyceride levels
A
  • LDL levels: decreased
  • HDL levels: increased or normal
  • triglyceride levels: decreased or normal
19
Q

Fibrates

  • LDL levels
  • HDL levels
  • triglyceride levels
A
  • LDL levels: mild decrease
  • HDL levels: mild increase
  • triglyceride levels: VERY decreased
20
Q

Niacin

  • LDL levels
  • HDL levels
  • triglyceride levels
A
  • LDL levels: decreased
  • HDL levels: highest increase of all the drugs
  • triglyceride levels: decreased
21
Q

PCSK9 Inhibitors

  • LDL levels
  • HDL levels
  • triglyceride levels
A
  • LDL levels: VERY decreased
  • HDL levels: increased
  • triglyceride levels: decreased
22
Q

what lipid-lowering agent decreases mortality in CAD patients

23
Q

what lipid lowering agent is the best at lower triglycerides

24
Q

which lipid lowering agents are best at lower LDL

A

statins

PCSK9 inhibitors

25
Q

alirocumab MOA

A

PCSK9 inhibitor

26
Q

evolocumab

A

PCSK9 inhibitor

27
Q

colestipol MOA

A

bile acid resin

28
Q

colesevelam MOA

A

bile acid resin

Maddy - First Aid (23 decks)

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