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NBB 2 > Anti-Depressants > Flashcards

Anti-Depressants Flashcards

1
Q

Blocks VMAT which impairs monoamine transmission and INDUCES depression

A

Reserpine

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2
Q

Says that the depressed mood results from decreased monoamine transmission

A

The Monoamine hypothesis

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3
Q

Serotonins and central adrenergic neurotransmission modulate

A

Mood

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4
Q

Depression represents a decreased availability of either

A

5-HT or NE or both

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5
Q

Which three classes of antidepressant function to block the re-uptake of neurotransmitters?

A

SSRI’s, SNRI’s, and TCA’s

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6
Q

Which class of antidepressants blocks the breakdown of neurotransmitters?

A

MAOI’s

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7
Q

Inhibit 5-HT reuptake selectively as compaired to NE

A

SSRI’s

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8
Q

Relatively selective for 5-HT transporter, thus Sid effects are limited to effects on 5-HT mediated responses

A

SSRIs

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9
Q

Venlafaxine and duloxetine are the two major

A

SNRIs

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10
Q

Inhibit reuptake transporters for BOTH 5-HT and NE

A

SNRIs

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11
Q

Inhibit reuptake transporters for BOTH NE and 5-HT like SNRIs but also tend to react with a variety of other receptors

-Broad range of side effects

A

Tricyclic Antidepressants (TCAs)

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12
Q

Phenelzine and tranylcypromine are the major

A

MAO Inhibitors (MAOI)

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13
Q

Used to treat major depression that is unresponsive to other drugs

A

MAOI’s

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14
Q

Combines irreversibly with MAO to provide long-lasting MAO inhibition

A

Phenelzine

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15
Q

Does not bind MAO irreversibly, but still has prolonged effect

A

Transcypromine

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16
Q

Can cause hypertensive reactions in response to indirectly acting sympathomimetics

A

MAOIs

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17
Q

Nefazodone and trazodone are the two major

A

5-HT2 antagonists

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18
Q

A prodrug that is converted to a 5-HT2 antagonist

A

Trazodone

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19
Q

Carries a black box warning due to hepatotoxicity

A

Nefazodone

20
Q

Can cause sedation and alpha-block (resulting in orthostatic hypotension)

A

5-HT2 antagonists

21
Q

Bupropion and mirtazapine are the two

A

Heterocyclics

22
Q

Used to treat major depression, smoking cessation, and as a sedative

A

Heterocyclics

23
Q

Bupropion is used to help with

A

Smoking cessation

24
Q

Mirtazepine is used as a

A

Sedative

25
Q

Enhances both NE and DA neurotransmission

A

Bupropion

26
Q

Antagonist at 5-HT2a/2c and 5-HT3 receptors

A

Mirtazapine

27
Q

Antagonist of presynaptic alpha-2 autoreceptor

-Enhances release of NE and 5-HT

A

Heterocyclics

28
Q

Most have rapid oral absorption and reach peak plasma concentration in 2-3 hours

A

Antidepressant agents

29
Q

Are tightly bound to plasma proteins

A

Antidepressants

30
Q

The metabolite of fluoxetine, norfluoxetine, has a long half-life, on the order of

A

7-9 days

31
Q

Venlafaxine is extensively metabolized via

A

CYP 2D6

32
Q

Parole time and fluoxetine are potent inhibitors of

A

CYP 2d6

33
Q

Fluvoxamine is an inhibitor of

A

CYP 3A4

34
Q

Antidepressants with sedative effects are additive with other sedatives, particularly

A

Alcohol and BZs

35
Q

Sensitize patients to indirect synmpathomimetics like tyramine and to sympathomimetics such as ephedrine

A

MAOIs

36
Q

Overdose is extremely dangerous and are prescribed on “no refill” basis

-Small quantities

A

TCAs

37
Q

Intoxication is rare

-Requires supportive treatment

A

MAOIs

38
Q

Used to treat bipolar disorder

A

Lithium

39
Q

Drugs that increase catecholamine activity exacerbate

A

Mania

40
Q

Drugs that reduce NE or DA activity tend to reduce

A

Mania

41
Q

Must be used carefully in bipolar patients to avoid induction of mania

A

Antidepressants

42
Q

Distributed in total body water and has slow entry to intracellular compartments

-Completely absorbed in 6-8 hours

A

Lithium

43
Q

Diuretics decrease renal clearance of Lithium by

A

25%

44
Q

Can decrease clearance by increasing Li+ reabsorption in proximal tubules

A

Some NSAIDs

45
Q

Common at therapeutic doses of lithium

-Controlled with propranolol or atenolol

A

Tremor

46
Q

Reversible decreases thyroid function

-Also causes reversible polydipsia and polyuria

A

Lithium

47
Q

Contraindicated in patients with severe dehydration or sodium depletion

A

Lithium

NBB 2 (21 decks)

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