Antenatal Screening

Question 1

how to estimate due date?

Answer 1

+280

9 months and 7 days

Question 2

what blood tests are done at booking?

Answer 2

Hb
random blood glucose
FBC
ABO
rhesus
syphilis
HIV
Hep B

Question 3

what other investigations are done?

Answer 3

urinalysis
BP
BMI

Question 4

for trisomy 21, when and what are the three investigations that can be done?

Answer 4

bloods
amniocentesis
chorionic villus sampling

Question 5

when is maternal anaemia screened for?

Answer 5

booking and 28 weeks

Question 6

where is AFP produced?

Answer 6

the yolk sac

Question 7

what is AFP used to screen for? why is it elevated in these cases?

Answer 7

spina bifida
gastroschisis
twins
-> increased exposure of fetal surfaces to amniotic fluid

Question 8

when is Rh screening and doses given? why would women be given a dose?

Answer 8

booking
28wks
34wks
if she needed anti D prophylaxis due to being rhesus negative

Question 9

if balanced, what genetic test can be used to find chromosome translocations?

Answer 9

aCGH

Question 10

what is the name for a balanced and unbalanced translocation?

Answer 10

balanced - reciprocal

unbalanced - robertsonian

Question 11

when can chorionic villus biopsy be done? what is miscarriage risk?

Answer 11

11.5wks

2%

Question 12

when can amniocentesis be done from? what is the miscarriage risk?

Answer 12

16 wks

1%

Question 13

when can fetal blood sampling be done?

Answer 13

18 wks

Question 14

from biggest to smallest, what genetic Ix cover large areas of the gene to small?

Answer 14

chromosome analysis
aCGH
PCR
NGS

Question 15

what immunity should it be ensured a pregnant women has?

Answer 15

rubella

Question 16

what supplements should a pregnant women be taking?

Answer 16

iron (if anaemic)
folic acid (until 4wks)
vit D

Question 17

when is the nuchal scan conducted? what is this for?

Answer 17

11-13

downs syndrome

Question 18

when is the anomaly scan done?

Answer 18

18-20

Question 19

when is the dating scan done? what is excluded here?

Answer 19

10-13

multiple pregnancy

Question 20

what dates are further routine care check done, if the women is a primip?

Answer 20

25 wks and 31wks

Question 21

if women is not a primip, when is second routine care check done?

Answer 21

28wks

Question 22

when is a urine culture done to detect asympt bacteria?

Answer 22

8-12 wks

Question 23

what are you looking for on anomaly scan?

Answer 23

brain malformations
cardiac problems
microcephaly
limb malformations

Question 24

what and when is the combined test for down’s done?

Answer 24

10-13wks
nuchal thickness
beta HCG
PAPP-A