ANI SCI 320 Lecture 18 : Immune Disorders and Chronic Disease

Question 1

What is needed to result in an over reaction of the immune system?

Answer 1

pre-sensitized (immune) state of the host

Question 2

How many classifications of Immune Hypersensitivity Reactions are there?

Answer 2

4

Question 3

What is Type I Hypersensitivity Reaction?

Answer 3

Allergy, Anaphylaxis and Atopy

Question 4

What is Type II Hypersensitivity Reaction?

Answer 4

Cytotoxic, anitbody-dependent

Question 5

What is Type III Hypersensitivity Reaction?

Answer 5

Immune Complex Disease

Question 6

What is Type IV Hypersensitivity Reaction?

Answer 6

Delayed Type Hypersensitivity

Question 7

What is an example of each type of Hypersensitivity Reaction?

Answer 7

I - Penut allergies
II - Rheumatic Fever
III - Lupus
IV - Multiple sclerosis

Question 8

1. Type I is what kind of hypersensitivity?
2. What cellular interactions are involved?

Answer 8

1. IgE Mediated Hypersensitivity
2. Ag induced cross linking of IgE bound to mast cells and basophils with release of vasoactive mediators

Question 9

1. Type II is what kind of hypersensitivity?
2. What cellular interactions are involved?

Answer 9

1. IgG-Mediated Cytotoxic hypersensitivity
2. Ab directed against cell surface antigens mediates cell destruction via compliment activation of ADCC

Question 10

1. Type III is what kind of hypersensitivity?
2. What cellular interactions are involved?

Answer 10

1. Immune Complex Mediated Hypersensitivity
2. Ag-Ab complexes deposited in various tissues induce complement activation and an ensuing inflammatory response mediated by massive infiltration of neutrophils

Question 11

1. Type IV is what kind of hypersensitivity?
2. What cellular interactions are involved?

Answer 11

1. Cell-Mediated Hypersensitivity?
2. Sensitized TH1 cells release cytokines that activate macrophages or Tc cells which mediate direct cellular damage

Question 12

What is sterile inflammation?

Answer 12

Tissue injury but no infectious agent present and innate recognition of tissue damage

Question 13

What is chronic inflammation?

Answer 13

If antigen persists, antigen reactive T cells can drive continued inflammation

Question 14

What is Recurrent activation?

Answer 14

Cyclical process that causes tissue damage

Question 15

What is Adiposity?

Answer 15

Major contributor to subclinical chronic infection

Question 16

What are 2 examples of chronic diseases in animals?

Answer 16

1. Arthritis
2. Chronic Kidney Disease