ANI SCI 320 Lecture 16 : Antibodies

Question 1

What are the 6 functions of antibodies?

Answer 1

1. Opsonization
2. Complement System Activation
3. Immobilization and Prevention of Adherence
4. Cross Linking
5. Antibody - Dependent Cellular Cytotoxicity
6. Neutralization

Question 2

What is another word for anitbodies?

Answer 2

Immunoglobulins (Ig)

Question 3

Antibodies are….

Answer 3

Y shaped proteins

Question 4

Antibodies have….

Answer 4

two copies of heavy chain and light chain

Question 5

Two identical variable regions that bind to the antigen is known as?

Answer 5

Specificity

Question 6

Stem is constant region is known as?

Answer 6

Immune System Recognition

Question 7

What are the 5 major classes of antibodies?

Answer 7

IgM, IgG, IgA, IgE, and IgD

Question 8

What is the structure of SOME antibodies?

Answer 8

Monomeric single unit structure

Question 9

What does each antibody class have?

Answer 9

Different constant region of heavy chain

Question 10

IgG has how many binding sites?

Answer 10

2 Monomer

Question 11

What is the most common IgG?

Answer 11

Ab

Question 12

Where is the location of IgG?

Answer 12

Blood, lymph, intestine

Question 13

Can IgG cross the placenta?
Are there any execptions?

Answer 13

Yes
Exception in cattle, sheet, pigs, or horses

Question 14

What can IgG activate?

Answer 14

Complement classical pathway

Question 15

What is the function of IgG?

Answer 15

Neutralization agglutination, compliment activation
First and most abundant during secondary response

Question 16

IgM has how many binding sites?

Answer 16

10 Pentamer

Question 17

IgM makes up what percent of total antibody in serum?

Answer 17

5-10%

Question 18

Where is the location of IgM?

Answer 18

Blood, Lymph, B cell surface

Question 19

Can IgM cross the placenta?
Are there any exceptions?

Answer 19

No
NO exceptions

Question 20

What does IgM activate?

Answer 20

Complement Classical Pathway

Question 21

What is then function of IgM?

Answer 21

First antibodies produced in response to first exposure to antigen

Question 22

IgA has how many binding sites?

Answer 22

4 binding sites Dimer with secretor component

Question 23

IgA makes up what percent of total antibody in serum?

Answer 23

10-15%

Question 24

Where is the location of IgA?

Answer 24

Secretions monomer, blood, lymph

Question 25

Can IgA cross the placenta?
Are there any exceptions?

Answer 25

No
No exceptions

Question 26

Does IgA activate compliment?

Answer 26

No

Question 27

What is the function of IgA?

Answer 27

Protection of mucosal surfaces neutralization and trapping of pathogens in mucus prevents attachment of pathogens to epithelial cells

Question 28

IgD has how many binding sites?

Answer 28

2 binding sites
Monomer

Question 29

IgD makes up what percent of total antibody in serum?

Answer 29

0.2 %

Question 30

Where is the location of IgD?

Answer 30

Blood, lymph, B cell surface

Question 31

Can IgD cross the placenta?
Are there any exceptions?

Answer 31

No
No Exceptions

Question 32

Does IgD activate compliment?

Answer 32

No

Question 33

What is the function of IgD?

Answer 33

Serves as B cells receptor initiation of acquired immune response

Question 34

IgE has how many binding sites?

Answer 34

Monomer 2

Question 35

IgE makes up what percent of total antibody in serum?

Answer 35

0.002%

Question 36

Where is the location of IgE?

Answer 36

Bound to mast and basophils through the body an blood

Question 37

Can IgE cross the placenta?
Are there any exceptions?

Answer 37

No
No exceptions

Question 38

What is the function of IgE?

Answer 38

Activation of basophils and mast cells against parasites and allergens. When bound to antigens, triggers the release of histamine from mast cells and basophils that contribute to inflammation and some allergic responses

Question 39

What cells can secrete IgM when first activated?

Answer 39

Plasma

Question 40

B cells where can switch to IgG?

Answer 40

Lymph Nodes

Question 41

B cells where can switch to IgA?

Answer 41

Mucosal Tissues

Question 42

The first response to antigen is called what?

Answer 42

Primary response

Question 43

The secondary response to the antigen is called what?

Answer 43

Secondary Response