Allergy & Immunology Flashcards
First antibody produced in an infection
IgM
Antibody that readily crosses placentA
IgG
Immunoglobulin that functions in mucosal defense
IgA
Immunoglobulin secreted in breast milk
IgA
Immunoglobulin involved in allergic reactions and parasitic infections
IgE
Protects against intracellular organisms and opportunistic infections
T cells
B cell deficiency lead to which type of infections
Recurrent sinopulmonary infections
Strep pneumo, H flu, staph aureus, entero virus, giardia
Infections B cell deficient patients are susceptible to
Skin and organ abscesses with staph aureus and catalase positive organisms
Phagocytic disorder
Blood cx positive for Serratia or Burkholderia
CGD
Overwhelming sepsis, pyogenic infection, neisseria meningitis
Complement deficiency
SCID, wiskott aldrich, ataxia telangictasia, Bloom syndrome, Nijmegen breakage syndrome
Combined B cell and T cell deficiency
Eczema, chronic lung infxn, chronic diarrhea, FTT, absent thymus
SCID
No T cells, No NK cells, B cells present
X linked SCID (dx: with flow cytometry and molecular analysis, tx: BMT)
No T cells, No B cells, No NK cells
Adenosine Deaminase Deficiency
Eczema, immunodeficiency, thrombocytopenia, small platelets
Wiskott Aldrich
Mode of inheritance: wiskott Aldrich
X linked
Tx Wiskott Aldrich
BMT or ppx abx and IVIG
Ataxia, telangiectasia, immunodeficiency
Ataxia Telangiectasia
AR defect in ATM gene responsible for DNA repair
Ataxia Telangiectasia
Elevated alpha fetoprotein
Ataxia Telangiectasia
Immunodeficiency with high risk of cancer (leukemias and lymphomas)
Ataxia Telangiectasia, Bloom Syndrome
AR deficiency of DNA ligase 1
Bloom Syndrome
Small stature, Telangiectasia, CNS anomalies, immunodeficiency
Bloom Syndrome
Bird like face, microcephaly, immunodeficiency, mild MR
Nijmegen Breakage Syndrome
Primary T cell deficiency
DiGeorge Syndrome, (have problems with INTRAcellular organisms)