Allergy and Immunology Flashcards
What’s the name for a severe immediate hypersensitivity rxn involving IgE binding to mast cells and leading to their degranulation?
Anaphylaxis
T/F: urticaria is considered part of anaphylaxis, not just an allergy?
True
What rxn presents with sudden swelling of the face, tongue, eyes, and airway?
Angioedema
Which common drug can cause angioedema?
ACE inhibitors
What’s the best initial test for angioedema?
C2 and C4 levels
What’s the tx for angioedema?
FFP, airway, epinephrine, antihistamine (if urticaria), C1 esterase inhibitor concentrate (for hereditary)
What drugs are appropriate angioedema prophylaxis prior to surgical and dental procedures?
Tranexamic acid, danazol, C2 esterase inhibitor
What’s a good antihistamine for seasonal allergies?
Loratidine
Which immunodeficiency presents with recurrent sinopulmonary infex in adults, along with diarrhea and intestinal issues?
Common Variable Immunodeficiency
What’s the pathogenesis of common variable immunodeficiency?
Ig levels are decreased and there’s a decreased response to antigen stimulation of B cells
What’s the treatment for common variable immunodeficiency?
Regular infusions of IV Ig
Which immunodeficiency presents in male children (X-linked) with absence of the tonsils, adenoids, lymph nodes, and spleen, and therefore diminished B cells, and is treated with IV Ig infusions?
X-linked (Bruton) Agammaglobulinemia
Which immunodeficiency presents with deficiency in both B and T cells and leads to “bubble boy” and is treated with BM transplant?
SCID
Which immunodeficiency presents with recurrent sinopulmonary infex, plus atopic diseases, anaphylaxis to blood transfusion, and vitiligo, RA, etc, and is treated supportively and by avoiding a certain thing in blood transfusions?
IgA Deficiency
Which immunodeficiency presents with recurrent staph skin infex and is treated with prophylactic abx like dicloxacillin?
Hyper IgE Syndrome
