Alcohol Flashcards
Alcohol
fermenting fruit, sugar dissolved in H2O & exposed to air, microbes (yeasts) consume it –metabolic by products of yeast – ethanol & CO2
Pharmacokinetics
- Tiny molecule, esp soluble in water
- Readily crosses blood brain barrier so blood & brain levels are equal
- Unique because it requires no digestion before it’s absorbed
- absorbed mainly through the capillaries in small intestines (although some absorption by the stomach
Factors that affect absorption
1) amount of food in the stomach
* type of food-milk or high protein seems to slow absorption
2) the rate at which the beverage is consumed
3) strength of alcohol in drink
Factor characteristics that affect absorption
weight, sex, hydration, status, carbonation, personal history
How do these fit with legal limit for driving?
- amount of alcohol in the blood by weight
- usually presented as mg of alcohol/100ml of blood
- blood alcohol consumption (BAC)
- legal level of intoxication varies across states - KS .08%
- LD50 ~.45%
kansas legal level?
0.08% (80mg/100ml)
B.A.C. & Behavioral Effects
the levels of alcohol in your system
0.05%
good feeling, release of inhibitions, impaired in judgement
.10%
slower reaction time, impaired motor function less cautious
.15%
much slower reaction time, vomit reflex
.20%
marked depression in sensory & motor capacity, intoxication
.25%
severe motor disturbance, staggering, sensory impairment
.30%
conscious, but no comprehension of what is going on
.35%
LD1
~.45%
LD50
Ethanol Metabolism
alcohol dehydrogenase, acetaldehyde dehydrogenase, cytochrome P450
Alcohol dehydrogenase (stomach)
women have lower levels, alcohol stays in system longer & has more of an effect
Acetylaldehyde dehydrogenase (liver)
30-50% of Asians this enzyme is inactive
- acetaldehyde builds up
- facial flush
- sweating
- nausea
- may account for “allergic reaction” to alcohol
Cytochrome P450
Metabolizes alcohol in addition to other drugs
- -alcohol metabolism has higher priority than other drugs
- -alcohol consumption may lead to higher levels of other drugs in the liver & blood
With repeated use, these enzymes increase in number “induction”
-increased rate of alcohol metabolism
when does it work in the brain?
depresses CNS activity: GABA
-affects all major NT systems
Excretion
body begins breaking down alcohol almost immediately
- aprox. 5-10% leaves the body unchanged in sweat, urine, & breath
- Remaining 90-95% must be metabolized