adverse drug reactions

Question 1

what is the therapeutic index

Answer 1

Question 2

what is defined as a narrow therapeutic index

Answer 2

<2

e.g. theophylline, warfarin, lithium, digoxin

Question 3

what are the phases of drug metabolism

Answer 3

Question 4

what phase are most adverse drug reactions due to

Answer 4

phase 1

Question 5

what is a type A adverse drug reaction

Answer 5

augmented pharmacologic effects

• dose dependent and predictable
• diuretics - HF - dehydration

Question 6

what is type B

Answer 6

bizarre effects

Question 7

what are types C, D, E, F

Answer 7

Question 8

herb and alternative therapies side effects

Answer 8

Question 9

what disease can NSAIDs and TZDs exacerbate

Answer 9

CHF

Question 10

which drugs can cause urinary retention in BPH patients

Answer 10

decongestants or anticholinergics

Question 11

what is constipation worsened by

Answer 11

calcium
anticholinergics
CCBs

Question 12

which drugs can exacerbate asthma

Answer 12

beta blockers

Question 13

what drugs do foods that are potassium rich interact with

-bananas

Answer 13

ACEIs, ARBs, K-sparing diuretics

Question 14

what foods will warfarin react with

Answer 14

foods that are vitamin E and K rich

-apples, chickpeas, spinach, nuts, kiwi, broccoli

Question 15

what drugs will foods that alter pH react with

-chicken, turkey, milk, cheese

Answer 15

• antibiotics, thyroid meds

- digoxin, diuretics

Question 16

steroid therapy long term effects

Answer 16

cushings disease

Question 17

beta blockers long term effects

Answer 17

diabetes

Question 18

NSAIDs long term effects

Answer 18

hypertension

Question 19

what are beta blockers end of treatment effects

Answer 19

withdrawal and angina