Acute care Flashcards
What does a negative base excess indicate?
Excess acid
Respiratory acidosis
- pH is high/low
- CO2 is high/low
pH low
CO2 high
Metabolic acidosis
- pH is high/low
- bicarbonate is high/low
pH is low
bicarbonate is low
Anion gap = (Na +K) - (Cl + HCO3)
true or false
True
In COPD patients, raised PaCO2 with a NORMAL HCO3 suggests acute/chronic problem
Acute
What is wells score used for?
Determining likelihood of PE
If wells score is low, what does this mean and what do you do?
PE unlikely
D-dimers
Hyperventilation causes which ABG pattern
Respiratory alkalosis
panic attack causes which ABG pattern
Respiratory alkalosis
Severe asthma typically causes which ABG pattern
Respiratory acidosis
DKA typically causes which ABG pattern
Metabolic acidosis
Severe vomiting causes which ABG pattern
Metabolic alkalosis
Drug overdose (eg aspirin) typically causes which ABG pattern
Respiratory alkalosis
Paient with renal colic. What is first line treatment?
Diclofenac
What is the landmark for a cricothyroidotomy
Cricothyroid membrane
unwell patient in ED. ECG shows narrow QRS complex which is regular. How do you manage?
Vagal manouevres
Then administer adenosine 6mg -> 12mg
unwell patient in ED. ECG shows narrow QRS complex which is irregular. What is this likely to be and how do you manage in ED?
Likely AF
Rate control: B-blocker / diltiazem
unwell patient in ED. ECG shows broad QRS complex which is regular. What is this likely to be and how do you manage in ED?
VT
Amiodarone (300mg IV over 20-60 mins)
Patient in ED wit bradycardia. What is first line management?
Atropine 500mcg IV
Paeds CPR outline
5 rescue breaths
CPR 15:2
Name 2 unshockable rhythms
PEA
Asystole
Name 2 shockable rhythms
VF
Pulseless VT
When should you avoid head tilt chin lift manouvre
in trauma cases where there is concern about cervical spine injury
Gudel is example of
- oropharyngeal airway
- nasopharyngeal airway
Oropharyngeal airway
Size of nasopharyngeal airway equates to
diameter of patient’s little finger
When might nasopharyngeal airway be contraindicated?
If ?base of skull fracture
Periorbial bruising
Battles sign
CSF rhinorrhoea
What do these signs suggest
Base of skull fracture
Name 3 advanced airway techniques
Endotracheal Intubation Laryngeal mask airway Surgical airway (needle cricothyrotomy)
What should be used in ?c spine trauma?
- head tilt chin lift
- jaw thrust
Jaw thrust
Airway management: when may suction be used?
If there is complete or partial visible LIQUID obstruction in the airway
Airway management: when may mcGills forceps be used?
If there is complete or partial visible SOLID obstruction in the airway
Name 2 types of airway adjuncts?
Nasopharyngeal airway
Oropharyngeal airway
How do you size a Gudel airway?
From the incisors to the angle of the mandible
What is the final option for airway management where you have been unable to clear obstruction, open airway and ventilate patient?
Surgical airway
- cricothyrotomy
Flail chest
Segment of rib cage breaks due to trauma
Where are chest drains inserted?
4th / 5th ICS mid axillary line in the safety triangle
Why might you use a Kendrick leg splint?
Femoral fracture
Minimum score of GCS
3
GCS 3 components
Eye opening (4 max) Verbal response (5 max) Best motor response (6 points)
Eye opening - GCS
4 - eye opens spontaneously
3 - eye opens to voice
2 - eye opens in response to painful stimulus
1 - eye does not open
Verbal response - GCS
5 - talking normally 4 - confused conversation 3 - inappropriate words 2 - incomprehensible sounds 1 - no speech
Best motor response - GCS
6 - normal movements, obeys commands 5 - moves towards painful stimulus 4 - normal flexion 3 - abnormal flexion 2 - extension 1 - no movement
Fasting before surgery
- food
- liquid
Fast for 6 hours before surgery (food)
Can drink water up to 2 hours before surgery
Anticoagulants need to be stopped before surgery. True or false?
True
How long before surgery do DOACs need to be stopped for?
24 hours before surgery
How long does COCP need to be stopped before surgery?
4 weeks
Surgery tends to increase/decrease blood sugar levels?
Increase
- due to the stress body is under
What are the 4 pillars of consent
Understand
Retain
Weigh up
Communicate decision
After an operation, what do patients complain of most?
Post op nausea and vomiting
When is clopidogrel stopped before operation ?
7 days
What are the 2 standard colours of adult cannulas?
Blue
Pink
3 pillars of general anaesthesia
Pain free
Not aware (patient is asleep)
Paralysis (not in all GA)
What % of air is oxygen?
21%
Where in the body is energy generated (which structure)?
Mitochondria
How much oxygen does a standard person USE per minute?
- 250ml/min
- 500ml/min
- 750ml/min
- 1000ml/min
250ml/min
What is the functional residual capacity?
Expiratory reserve volume + residual volume
In anaesthesia, why is pre-oxygenation used (ie hold oxygen mask to patient’s face for 3 mins)
This replaces the functional residual capacity with 100% oxygen (instead of 21% oxygen) so it essentially buys time by increasing oxygen in the lungs
Who should not receive a laryngeal mask airway (LMA) ?
Patient’s with reflux
- it doesn’t protect their airway
Patients with reflux should have which airway?
Endotracheal tube
- it has a cuff to protect the airway
For patient about to have surgery, which CARDIAC medications should be stopped on day of surgery? (and why?)
ACE inhibitor
Angiotensin receptor blocker
Thiazide diuretic
being anaesthetised causes hypotension but these drugs will cause prolonged hypotension
How long should aspirin be stopped before surgery?
7-10 days
How long should DOACs be stopped before surgery?
24-48 hours
Warfarin and surgery
Stop warfarin 5 days before surgery
Day 3 before surgery start LMWH injections for 2 days
After op restart LMWH injections + warfarin
When INR normal, stop LMWH injections
Patient 7 hr post op complains of pain despite having an epidural pre-operatively. What should be done first?
Check sensory block height
Patient develops broad complex tachycardia HR 160 BP 80mmHg systolic What should be done? - adenosine - amiodarone - synhronised DCCV - CPR
Got a pulse so CPR not required.
However, he is unstable so 3 x synchronised DCCV required first line
Patient develops broad complex tachycardia HR 120 BP 100mmHg systolic What should be done? - adenosine - amiodarone - synhronised DCCV - CPR
Amiodarone IV infusion
What ECG features do you need to diagnose STEMI
over 2mm in 2 contiguous chest leads OR
over 1mm in 2 contiguous limb leads OR
New LBBB
Identify a STEMI what is the management plan
Morphine Oxygen (only if needed) Nitrates Aspirin Ticagrelor
IV heparin (if going onto PCI)
PCI
In MONA + C what is used instead of clopidogrel now
Ticagrelor
Why does infection cause increased resp rate
Pain
Fever
If you need to fluid resuscitate a patient but there is a risk that the patient could get fluid overloaded, what do you do>
250ml (instead of 500ml) IV fluids (crystalloid)
frequent reassessment is crucial
All COPD patients have 88-92% oxygen range target. True or false ?
True
- even if not normally a CO2 retainer
How can you tell if someone is a CHRONIC CO2 retainer or an acute CO2 retainer?
If chronic, there will be metabolic compensation on the ABG
What is the treatment for acute exacerbation of COPD
Oxygen Nebulisers: salbutamol 5mg Nebulisers: Ipatropium bromide Amoxicillin Prednisolone 40-50mg
Non invasive ventilation is the same as BiPAP. True or false/
True
Explain how NIV works
Patient inhales themselves and BiPAP mask supplements with bursts of pressure and pushes air into the lungs
T wave inversion on an ECG suggests
Ischaemia
- NSTEMI
What is the management of NSTEMI
Morphine Oxygen (if required) Nitrates Aspirin Ticagrelor
+ FONDAPARINEUX
Key points to ask in history of head injury
MECHANISM of injury loss of consciousness vomiting (one off vomit is ok) visual disturbance associated injuries seizures amnesia
Suspicious of base of skull fracture, what airway adjunct should you avoid?
Nasopharyngeal airway
Reduced GCS
Unequal pupils
What does this potentially suggest?
Raised intracranial pressure
Battles sign suggests
Base of skull fracture
Where should you test for pain (if needed) in GCS?
Trapezius squeeze
GCS 8 or less equates to what on AVPU
Response to Pain (P)
3rd nerve palsy: dilated/constricted pupil?
DILATED pupil
Name 4 base of skull fracture signs
Battle’s sign (behind the ear)
CSF leak from nose
Racoon / panda eyes (bilateral bruising around the eyes)
Haemotympanum
Hypertension
Bradycardia
Irregular breathing
CUSHINGS TRIAD
caused by reduced brain stem perfusion
Raised ICP causes increased/decreased cerebral blood flow
Decreased
Anyone with a GCS less than 13 and a head injury should have a CT scan within which time frame?
1 hour
Indications for CT imaging within 1 hour (5)
GCS less than 13 Any sign of base of skull fracture Focal neurological deficit Post-traumatic seizure More than 1 episode of vomiting
For adults who have sustained a head injury and have any of the following risk factors, perform a CT cervical spine scan within 1hour of the risk factor being identified. Name 2 risk factors
GCS less than 13
Patient that has been intubated
Acute blood on a CT scan is what colour?
white
Subdural haemorrhage crosses suture lines. True or false?
True
Subdural haemorrhage often sudden/insidious?
Insidious
Extradural haematoma - caused by which artery usually?
Middle meningeal artery
Management of an extradural haematoma
Causes significant pressure
Neurosurgical theatre - burr hole
Young people -> brief LOC -> lucid interval -> rapid deterioration
Extradural haematoma
What is a spondylolisthesis?
When one of the vertebrae slips out of place onto the vertebrae below it
Low backache, worse after activity, relieved by rest. What does this make you think of ?
spondylolisthesis
Traumatic twisting injury to the knee when the leg is bent, and being unable to straighten knee (locked) suggests
medial meniscal injury
Patient miscalculated stairs, put full weight on right leg with knee straight. Clinical haemarthrosis, tenderness maximally laterally, straight leg raise causes significant tenderness. What is most likely?
- patellar fracture
- tibial plateau fracture
- quadraceps tendon rupture
- ACL rupture
Tibial plateau fracture
Which ligament is the most commonly injured in inversion injuries
- anterior talofibular
- posterior talofibular
- calcaneofibular
- tibionavicular
Anterior talofibular
Septic artthritis suspected. What is best investigation?
Aspiration of synovial fluidd
50 year old patient with a fracture following a fall. Has had previous total hysterectomy and bilateral salpingectomy. What is the appropriate management?
- oestrodiol
- alendronic acid
- calcitriol
- tibolone
Alendronic acid
Young male with asthma. 4-6 attacks of migraine with aura per month. Needs prophylactic treatment. What treatment do you advise?
topiramate
would be propranolol but he is asthmatic
pain that runs from the buttock through the back of the thigh and into the calf and outside of the foot (ie all down the leg). Numbness on lateral aspect of foot. What is likely nerve involved?
- common peroneal nerve
- L5 radiculopathy
- S1 radiculopathy
- cauda equina compression
S1 radiculopathy
Someone with paracetamol overdose turns up to the ED within 1 hour. What do you do?
Give activated charcoal
What is the antidote for paracetamol?
N-acetylcystine
Methionine
What is the antidote for beta blockers?
Glucagon
What is the antidote for opioids?
Naloxone
Paracetamol is converted by which system to ____
Paracetamol is converted by the Cytochrome P450 system to NAPQI
What are the common EARLY features of paracetamol poisoning?
Nausea and vomiting
Delayed presentation of paracetamol poisoning (2-3 days later) features may include
features of hepatic necrosis
- right subcostal pain
- nausea and vomiting
- jaundice
When should blood paracetamol levels be checked?
4 hours
How is N-acetylcystine given?
IV
given over 20 hours
If blood paracetamol levels are checked at 4 hours and it is above the treatment line, what is used?
N-acetylcystine
If the patient’s blood paracetamol level is elevated at 4 hours and they need treatment, what blood work is done after the treatment? and if the blood work is abnormal what is done?
INR
LFT
U+E
If these are abnormal - continue with N-acetylcystine
What is rapid sequence induction?
A way of inducing anaesthesia in patients at risk of aspiration of gastric contents
In CPR, after how many shocks do you start administering drugs ?
after 3rd shock
What are the reversible causes of cardiac arrest?
4H’s and 4Ts
- hypovolaemia
- hypothermia
- hypoxia
- hypo/hyper kalaemia
Tension pneumothorax
Cardiac tamponade
Toxins
Thrombus
After 3rd CPR shock which 2 drugs do you administer
Adrenaline 1mg
Amiodarone 300mg
Repeat adrenaline every 3-5 mins
30 yo male, painful red eye for a week, worst at night. long sighted. What is likely diagnosis?
Acute angle closure glaucoma
Eye trauma with suspected penetrating injury. What is the first line investigation?
CT orbits
Patient develops acute muscle spasms after being treated with halloperidol yesterday. What is first line treatment?
- baclofen
- diazepam
- procyclidine
Procyclidine
Which colour of cannula is 22 gauge?
blue
Name the colours of cannula from smallest to biggest
Blue - 22
Pink - 20
Green - 18
Grey - 16
What colour of cannula is the ‘go to’ for non-emergency patients?
Pink
Chronic pain is pain lasting longer than _____
Lasts longer than 3 months
Which type of pain is being described here: burning, shooting, numbness, pins and needles, not well localised
Neuropathic pain
What are the 4 steps involved in pain physiology
Periphery
Spinal cord
Brain
Modulation
Pain signals travel in which 2 nerves to the spinal cord
A-delta nerve fibres
C nerves
Which part of the spinal cord is involved in pain: dorsal horn or ventral horn
Dorsal horn
In which part of the brain does pain perception occur?
- cortex
- limbic system
- brainstem
Cortex
WHO pain ladder (3 steps)
- Paracetamol +/- anti inflammatory (iboprufen, diclofenac)
- Codeine
- Morphine, oxycodone
Drug (and non-drug) treatments for nociceptive pain (at periphery level)
R.I.C.E
Anti-inflammatory (ibuprofen, diclofenac)
Local anaesthetic
Drug (and non-drug) treatments for nociceptive pain (at spinal cord level)
Acupuncture
Local anaesthetic
Opioid
Ketamine
Drug (and non-drug) treatments for nociceptive pain (at brain level)
Paracetamol
Codeine
Morphine
Amitryptiline
What is the biggest disadvantage of paracetamol
Liver damage in overdose
Codeine is better for acute or chronic pain?
Acute
Addiction is rare/common in acute pain?
Rare
What is a good medication to use for post-operative pain?
Morphine
Oral dose of morphine is 2-3 times IV / IM / SC dose. Why is this?
Due to tolerance
- increased doses needed over time
Tramadol is a controlled drug. True or false?
False
What are the disadvantages of using amitryptiline?
Anti-cholinergic side effects (dry mouth, constipation)
What is a good medication for chronic cancer pain?
Morphine
Patient with chronic pain presents with worsening pain. What do you do?
Continue normal opioids
add extra opioids to cover acute pain
Which pain medications should be avoided in renal failure?
NSAIDs
Paracetamol mechanism of action?
Inhibits prostaglandin synthesis in the CNS
Management of opioid induced respiratory depression
Give oxygen
Adjust dose or stop delivery of opioid
Give naloxone if necessary
Tramadol is a strong/weak opioid?
Weak
Patient is on anticoagulants. This means epidural cannot be administered. True or false?
True
Name an antihistamine used in nausea and vomiting?
Cyclizine
Name a 5HT3 antagonist?
Odansetron
Name 3 different classes of anti-emetics
Antihistamine
5HT3 antagonist
Anti-dopaminergic
What is the first line treatment for a raised INR ?
Vitamin K
It is very important to know that medication can be given (with a sip of water) to patients that are fasted for theatre. true or false?
True
Emergency treatment of coagulopathy?
FFP
INR ___ and below then it is ok to proceed with operation?
1.5 and below
Standard PCA (patient controlled analgesia) prescription is what?
1mg morphine bolus, 5 min lockout
Who goes to HDU, who goes to ICU ?
HDU - one failing organ
ICU - over one failing organ
If you need invasive ventilation, where do you go?
Ward
HDU
ICU
ICU
Define inotrope
A substance that affects the force of muscular contraction in the heart
Define vasopressor
A hypOtensive agent (used to raise blood pressure)
Inotropes must always be given by infusion through a central venous catheter. True or false?
true
Name 2 examples of inotropes
Adrenaline
Dobutamine
What 2 groups of antacids are commonly prescribed?
PPI (omeprazole)
H2RA (Ranitidine)
Can antacids be given on the morning of surgery?
Yes
Which drug is commonly used prior to induction of anaesthesia?
Midazolam
Benzodiazepines bind to which receptor?
GABA receptor
Name 3 IV anaesthetic agents
Propofol
Ketamine
Sodium thiopentate
Name 3 volatile anaesthetic agents
Sevoflurane
Desflurane
Isoflurane
Why are neuromuscular blocking drugs administered in anaesthesia?
To relax / paralyse muscles
Facilitate intubation
Name 1 depolarising neuromuscular blocking agent?
Suxamethonium
What has quicker onset of action
- depolarising neuromuscular blocking agent
- non-depolarising neuromuscular blocking agent
depolarising neuromuscular blocking agent
Name 4 opioids
morphine
fentanyl
Alfentanil
Remifentanil
name 2 topical anaesthetics used in paediatrics
EMLA
Ametop
Different intravenous fluids cause different effects on body fluid compartments.
If you infuse: 1 litre 0.9% Saline or Hartmann’s (crystalloid).
You get an increase in
- ICF
- ECF
- both
ECF (interstitial fluid + plasma)
Different intravenous fluids cause different effects on body fluid compartments. If you infuse: 1 litre 5% Glucose. you get an increase in - ICF - ECF - both
Both
Frail 82 year old lady who broke her ankle and was found lying on the floor a day later. She is drowsy with dry mucous membranes. Urea and creatinine are raised. What fluid should you give?
- crystalloids
- 5% glucose
5% glucose
This lady has been lying on the floor and is dehydrated. She needs water which can be provided by 5% glucose.
16 year old female involved in a road traffic accident. She has an open femoral fracture which is bleeding profusely. She is pale, tachycardic but normotensive. Which fluid should you give?
- crystalloids
- 5% glucose
This lady is hypovolaemic because of blood loss and again needs a fluid that will restore her circulating volume. Crystalloid is a good initial choice in this situation. Colloid, although not offered as a choice in this tutorial, would also be an acceptable choice for treating haemorrhagic shock. Ultimately, of course, this patient may require blood.
If bradycardia is accompanied by life-threatening adverse signs, what is the treatment
a. Electrical Synchronised DC Shock
b. Amiodarone 300mg IV Infusion
c. Adrenaline 2-10 mcg min IV Infusion
d. Atropine 500mcg IV until max of 3 mg
e. Adrenaline 0.5mg 1M repeated until a response
d. Atropine 500mcg IV until max of 3 mg
SVT not responding to vagal manouvres. What do you do?
a. Adrenaline 2-10 mcg min IV Infusion
b. Electrical Synchronised DC Shock
c. Amiodarone 900 mg IV Infusion over 24 hr
d. Adenosine 6 mg bolus rapid IV injection
e. Adenosine 12 mg bolus rapid IV injection
D
6mg -> 6mg -> 12mg
Prior to completion of N-acetyl cystine infusion, which bloods should you check?
“post parvolex bloods” - LFT, INR, U+E
If ‘post parvolex bloods’ are normal, what do you do?
Discharge patient and psycho input if required
If ‘post parvolex bloods’ are abnormal, what do you do?
Continue acetylcysteine at the dose and infusion rate used in the 3rd treatment bag
How long is the current N-acetyl cystine infusion?
21 hours
Signs of ANTICHOLINERGIC toxicity
Dilated pupils
Dry mucous membranes
Confusion
What is the antidote for anticholinergic toxicity
sodium bicarbonate
What is the antidote for propranolol
Glucagon
72 year old female. Known insulin dependent diabetic. Found unconscious at home. GCS 3, P 80, RR 15, BP 154/83. Pale, sweaty and clammy. Paramedics BM 14.1, Repeat BM 1.7. What is best immediate management? A Give IV dextrose 5% 500mls B Give IV Naloxone C Give IV dextrose 10% 200mls D Give IV flumazenil 200 micrograms E Commence bag and mask ventilation F Perform RSI and CT head
C - IV dextrose 10% 200mls
78 year old female. Thin and frail but mentally alert. Simple fall onto R hip which is painful on any movement. Distressed by pain. How do you manage pain?
IV morphine + fascia iliaca block
Treatment of complete heart block
Atropine 0.5mg bolus up to 3mg
In which 2 situations do you need to be cautious about giving adenosine?
Asthmatics - bronchospasm
if patient is on CCB (prolongs half life)
18 year old male. Has just eaten a takeaway kebab. Sudden onset lip and facial swelling. Feels his throat is tight and has difficulty breathing.
P120 reg BP 85/40 sats 98%
What is your immediate treatment? (include dose)
IM adrenaline 500mcg
0.5mls of 1:1000
23 year old male. Crushed between heavy machinery at work. Painful pelvis. P120 reg, BP 76/50, sats 100%. Pelvic X-ray shows open book pelvic fracture. What do you do in the ED department
ABCDE Pelvic binder O negative blood Tranexamic acid Morphine
How do you manage a depressed skull fracture?
Requires referral to neurosurgery for elevation of the bone fragments and wound care
Which drug is used in the cute management of thyroid storm?
IV propranolol
Patient with hashimotos thyroiditisi comes for check up after being started on thyroxne 75mcg OD. What is the single most important blood test to assess response to treatment? Free T4 Total T4 Free T3 TSH ESR
TSH
The correct dose and route of adrenaline for administration during cardiac arrest is 1mg IM 0.1mg IV 0.5mg IV 1mg IV 0.5mg IM
1mg IV
Salbutamol causes tachycardia or bradycardia?
Tachycardia
- because it works on B2 receptors in the heart. Don’t need to treat it
1g oral paracetamol 6 hourly as required
OR regular oral paracetamol 1g (4 times daily)
Which is best
regular oral paracetamol 1g (4 times daily)
Type 1 diabetic going for day case short minor surgery. What should be done
Aim for ‘first on the list’
Omit all diabetes meds and insulin (APART FROM LONG ACTING INSULIN) on the morning of surgery
Restart all meds with first meal post op (apart from metformin)
Salbutamol causes tachycardia or bradycardia?
Tachycardia
Should you give fluids in acute asthma attack?
Yes if patient is dry
What is the minimum acceptable urine output?
> 0.5ml/Kg/hour
Sepsis leads to inappropriate vasodilation and hypotension. True or false?
Truee
Cardiac output sum
HR x SV
BP = ? x ?
BP = CO x SVR
What is the minimum acceptable urine output?
> 0.5ml/Kg/hour
Which of the following retains fluid
- oncotic pressure
- hydrostatic pressure
Oncotic pressure
Which of the following forces fluid out of vessel
- oncotic pressure
- hydrostatic pressure
Hydrostatic pressure