Acetylcysteine Flashcards
1
Q
Indications for Acetylcysteine
A
Acetaminophen overdose
2
Q
Adult dosing for Acetylcysteine
A
Loading dose: 150 mg/kg IV/IO to a single max 15g over 60min
Maintenance dose: 15mg/kg/hr IV/IO over a min of 20hrs. Single max rate of 1.5g/hr.
Use a concentration of 30mg/mL except in pediatrics who require fluid restriction in which case use 50mg/mL. Preferred fluid is D5W
3
Q
Contraindications for Acetylcysteine
A
None when used in acetaminophen overdose. Administering the loading dose over 60min may decrease the incidence of hypersensitivity reactions. A max weight of 100kg should be used when calculating dosage in obese patients.
