Abdo surgery Flashcards
Which hernias can only be found in laparotomy
Obturator; Gluteal; Sciatic; Pelvic; Pudendal Hernia
Only arteries supplying rectus abdominus if patient has had CABG
Inferior epigastric
If difficult access in AAA surgery what structure needs to be divided
Left renal vein
Types of arterial aneurysm
Fusiform Aneurysms
Appear as symmetrical bulges around the circumference of the aorta. They are the most common shape of aneurysm.
Saccular Aneurysms
Asymmetrical and appear on one side of the aorta. They are usually caused by trauma or a severe aortic ulcer.
Which direction do aortic aneurysms rupture
- 20% rupture anteriorly into the peritoneal cavity. Very poor prognosis.
- 80% rupture posteriorly into the retroperitoneal space
Spurarenal AAA mx
hese patients will require a supra renal clamp and this carries a far higher risk of complications and risk of renal failure.
Features favoring a suitable aneurysm for EVAR
- Long neck
- Straight iliac vessels
- Healthy groin vessels
Anatomical relations of coeliac axis
Anteriorly -Lesser omentum
Right -
Right coeliac ganglion and caudate process of liver , IVC
Left- Left coeliac ganglion and gastric cardia
Inferior -
Upper border of pancreas and renal vein
What does the gasproduodenal artery branch into
Right gastroepiploic artery and the superior pancreaticoduodenal artery
Supraduodenal branches off it earlier
Branches of IVC and vertebrae levels
T8 Hepatic vein, inferior phrenic vein, pierces diaphragm
L1 Suprarenal veins, renal vein
L2 Gonadal vein L1-5 Lumbar veins
L5 Common iliac vein, formation of IVC
Patient has SVC obstruction, which collateral can be an alternative pathway
Azygos venous system
Internal mammary venous pathway- connect to superficial epigastric
Lateral thoracic venous system with connections to the sueperficial circumflex iliac and vertebral veins (2 pathways)
Relations of SMA
Superio- neck of pancreas
Postero-inferior- third part of duodenum , ucinate process
Posterior-left renal vein
Right- superior mesenteric vein
Branches of SMA
M iddle colic
I liocolic (Appendicular artery is the branch of iliocolic artery) I nferior pancreaticoduodenal
R ight colic
J ejunal+ i leal (12-15 branches)
Which structure does the midgut bend around to form midgut loop
SMA
Arteries encountered in each colorectal surgery
Right hemi- RC, iliocolic (+middle if extended
splenic- right extended
Left- IMA
Hartmann- high ligation of IMA
AP- IMA
A- IMA
Pudendal nerve branches
Inferior rectal - around anus, anal canal below pectinate line
Perineal - post scrotum
Dorsal penis/clotoris- body and glans of penis
Structures at transpyloric plane
From posterior to anterior, the significant structures crossed by transpyloric plane in midline are:
The conus or termination of the spinal cord L1 vertebra
Aorta
Superior mesenteric artery
Neck of the pancreas Superior mesenteric vein The pylorus of the stomach
More laterally at this level:
Kidney hila
Renal vein
Hilum of the spleen
Second part of duodenum
Origin of the portal vein Duodenojejunal flexure
Fundus of the gall bladder
9th costal cartilage
Content of rectus sheath
2 muscles- RA and pyramidalis
4 vessels
* Superior Epigastric Artery and Vein
* Inferior Epigastric Artery and Vein
6 nerves
* Lower five intercostal nerve (T7-T11)
* Subcostal nerve (T12)
Arterial supply of anterior abdomen
Lateral side (Deep Branches)
* 10th and 11th Posterior Intercostal Arteries (← Descending Aorta)
* Subcostal Artery (← Descending Aorta)
* Lumbar Arteries(all 4) (← Descending Aorta)
Anteriorly From Above Downwards(Deep Branches)
* Musculophrenic Artery (← Internal Mammary Artery)
* Superior Epigastric Artery (← Internal Mammary Artery)
Anteriorly From Below Upwards (Deep Branches)
* Inferior Epigastric Artery (← External Iliac Artery)
* Deep Circumflex Iliac Artery (← External Iliac Artery)
Superficial Arteries
* Superficial Circumflex Iliac Artery (← Femoral Artery) * Superficial Epigastric Artery (← Femoral Artery)
Thoracoepigastric veins
These are Longitudinal venous connections between Lateral Thoracic Vein (→ from Cephalic Vein) and Superficial Epigastric Vein (→ GSV).
Provide a collateral route for venous return if a caval or portal obstruction occurs.
Border of ischiorectal fossa
Anterior- perineal membrane
Post- G max, sactotuberous lig
Lateral- ischial tuberosity, obturator internees, pudendal canal (Alcock canal)
Medual- levator ani, ext anal sphincter
Apex- meeting of ob fascia and inf fascia pelvic diaphragm
Most common sites for intra abdominal collection when supine
Hepatorenal Pouch of Rutherford-Morrison (Right Subhepatic Space)
Features which should be expected/ or occur without pathology on abdo radiology
- In Chiladitis syndrome, a loop of bowel may be interposed between the liver and diaphragm, giving the mistaken impression that free air is present.
- Following ERCP (and Sphincterotomy) air may be identified in the biliary tree.
- Free intra abdominal air following laparoscopy / laparotomy, although usually dissipates after 48– 72 hours.
Mushroom, caterpillar, claw, thumb printing and coffee bean sign on AXR
Caterpillar and mushroom- pyloric stenosis
Thumb printing- pseudomembranous colitis, UC, crohns, DD, IC
Claw- interssusception
Coffee- sigmoid
Derivatives of Dorsal Mesogastrium
G. omentum (gastrosplenic, gastrophrenic, gastrocolic) Splenorenal ligament (pancreas tail is here…)
Spleen pancreas develop within but not from
Derivatives of ventral Mesogastrium
Liver
Lesser omentum
Nerve supply of oesophagus
The parasympathetic component of the cervical part is supplied by the recurrent laryngeal nerve (a branch of the vagus nerve (CN X)) while the sympathetic fibers arise from the cervical sympathetic trunk.
The thoracic part of the esophagus is innervated by the esophageal plexus, an autonomic nervous network surrounding the esophagus. The parasympathetic component of the plexus originates from the vagus nerve, while the sympathetic fibers also stem from the sympathetic trunk running along the neck.
LN drainage of oesophagus
Upper- deep cervical
Mid - posterior mediastinal
Lower- left gastric
GORD gold standard
pH monitoring
Red flags for upper GI malignancy
Any patient with dysphagia
Any patient >55yrs with weight loss and upper abdominal pain, dyspepsia, or reflux
Patients with persistent symptoms, despite trialling conservative management
Surgical intervention for GORD
Floppy Nissen 3600 fundoplication(Post. Partial & Ant. Partial)
Which cells are present in barrets
- Presence of goblet cells important in identification
- Squamous epithelium replaced by columnar epithelium in the lower oesophagus
Corkscrew sing on barium swallow
Diffuse oesophageal spasm
Pseudoachalasia
Extrinsic tumour at GEJ
Cancer at risk in achalasia
SCC
Tx of DOS
Nifedipine
Ix of achalasia
Endoscopy to exclude malignancy
Mamometry gold standard
Mx of achalasia
Endoscopic Balloon Dilatation
then Heller Myotomy
Mx of oesophageal cancer
Surgical resection–
o Neoadjuvent chemotherapy is given in most cases prior to surgery
o In general resections are not offered to those patients with distant metastasis, not to those with N2
disease.
In situ disease – Endoscopic Mucosal Resection
Ivor Lewis
Or Mckneown
Ivor lewis procedure
– Initial laparotomy and construction of a gastric tube(A Rooftop Incision is made)
– Right thoracotomy to excise tumor and create an esophagogastric anastomosis. (Incision through
5th ICS performed 10cm above the tumour)
– Preferred for middle & lower third tumor
– Azygos Vein is divided to allow mobilization of oesophagus
Post Ivor lewis complications
*Atelectasis– due to the effects of thoracotomy and lung collapse
*Anastomotic leakage – High risk because of a relatively devascularised stomach as the only blood supply is from Gastroepiploic Artery and others have been divided.
Arteries effected by ulcers
Post gastric- splenic
Lesser curv- left gastric
Greater- gastroepiploic (GDA)
Post duodenal- gastro duodenal (CHA)
Regulation of gastric acid production
Factors increasing
Vagus
Gastrin
Histamine
Decreasing
SS
Secretin
CCK
Dilafeuoy Lesion
Vascular malformation in gastric fundus
Difficult to see on endoscopy
Big haematemesis
No prior episodes
Upper GI bleed management
Blatchford - Hb, serum urea, pulse rate and blood pressure
>0 endoscopy
Rockall- mortality
Varices should be banded or subjected to sclerotherapy. If this is not possible owing to active bleeding then a Sengstaken- Blakemore tube -should get terli and abx before
Patients with erosive oesophagitis / gastritis should receive a proton pump inhibitor.
Identifiable bleeding points should receive combination therapy of injection of adrenaline
What needs to be divided to gain access to coeliac axis
Lesser omentum
Post gastrectomy complications
Anaemia
Metabolic Bone syndrome
Cancer- adeno
Dumping/diarrhoea
Early satiety
Bile reflux
Gastroparesis
Recurrent ulceration
ABCDEFG
Gastrectomy surgeries
Billroth 1- Distal 3rd stomach removed & anastomosis - duodenum
Bilroth 2- Removal of distal 2/3rd stomach & gastro– jejunostomy
Total and subtotal gastrectomy with Roux en. Y- oesophagus or stomach to jejneum and duodenojejenostomy
So stomach to jejenum and duodenum cut from stomach and stuck to jejenum
What can you use to identify appendix in surgery
Caecal taenia coli converge at base of appendix and form a longitudinal muscle cover over
Nerve injured in appendectomy
Illiohypogastric
Which parts of colon are intraperitoneal
The sigmoid,transverse and appendix are wholly intraperitoneal.
Colon polyp appearance in HNPCC
Mucinous, poorly differentiated and “signet-ring” in appearance.
Referral for colonoscopy
≥40yrs with unexplained weight loss and abdominal pain
≥50yrs with unexplained rectal bleeding
≥60yrs with iron‑deficiency anaemia or change in bowel habit
Positive occult blood screening test
Ix for rectal cancer tissue invasion
MRI
Dukes staging
Dukes A- bowel wall
B1- Musculosa propia
B2- through MP and serosa no LN
C- LN, no mets
C2->4
D- distant mets
Differentiating between UC and Crohns
EIM more common in UC
UC spares rectum
Fistula, fissure, mass, strciture, fat wrapping- CD
Psuedopolyp, goblet depletion, crypt abscess, malignancy- UC
Non- caesating granuloma, cobblestone mucosa- CD
Bleeding more common in UC
GB and kidney stones- CD
EIM of IBD
Arthritis
Uvesitis
Pyoderma gangrenosum
Clubbing
PSC- UC
Surgery for UC
Emergency - toxic megacolon, colonic perforation, or uncontrolled bleeding- Subtotal colectomy + end ileostomy
Electively- pan protocolectomy +/- ileoanal pouch
Dysplasia with mass- proctocolectomy
Mx of high output fistula
Octreotide
Fascia of rectum
Anteriorly lies the fascia of Denonvilliers.
Posteriorly lies Waldeyers fascia.
Nerve supply above and below pectinate line
Above- inf hypogastric L1,2
Pelvic splanchnic
Below- inferior rectal
Tx of haemorrhoids
Symptomatic 1st or 2nd- band ligation
2nd-3rd- Haemorrhoidal artery ligation - main vessel supplying the haemorrhoid is identified through Doppler and then tied off, such that the haemorrhoid infarcts and falls off.
3rd-4th- haemorrhoidectomy
Goodsall rule
Anterior- straight path
Posterior curved path
Types of anal fistula
Superficial - superficial to sphincters
Intersphincteric- fistula penetrates through the internal sphincter but spares the external sphincter.
Suprashincteric - penetrates through the internal sphincter and then extends superiorly in the plane between the sphincters to pass above the external sphincter before extending to the perineum
Transphinteric- The fistula passes through both the internal and external sphincters through both
Extrasphincteric - laterally to the internal and external sphincter.
Tx of anal fistula
Intersphincteric- fistulotomy-make continuous with anus
Denatate line and above- seton suture
Others- fistulectomy- cut out
Mx of anal fissure
1st line- GTN- 8wks
2nd- if headache- diltiazem
Chronic- botulism toxin
Lateral internal sphincterotomy
Advancement flaps
Abdo pain, fever, multiple fine lesions between liver and abdo wall
Fitz High Curtis syndrome
Abdominal compartment syndrome dx
Sustained intra abdominal pressure >20mmHg along with new organ dysfunction / failure.
Tx of abdominal compartment syndrome
Non operative
Gastric decompression
Muscle relaxants
Drain fluid and consider fluid restrict
Surgical
Laparotomy and laparotomy with Bogota or VAC
Different GI parasitic infections
Enterobiasis- pruitis ani
Mebendazole
Ancylostoma- hookworm- larvae in stool- IDA- medendazole
Ascariasis- duodenum, lungs- mebendazole
Strongyloidiasis- skin- lungs- motile larvae in stool-
Mebendazole
Giardiasis- pear shaped- watery diarrhoea
Metronidazole
LN drainage of vagina
Superior – drains to external iliac nodes
Middle – drains to internal iliac nodes
Inferior – drains to superficial inguinal lymph nodes.
Where is leptin produced and what is its function
Produced by adipose tissue and acts on satiety centres in the hypothalamus and decreases appetite.
More adipose tissue (e.g. in obesity) results in high leptin levels.
Leptin stimulates the release of melanocyte
Where gherlin is produced and function
It is produced mainly by the fundus of the stomach and the pancreas. Ghrelin levels increase before meals and decrease after meals
Guidelines for bariatric surgery
BMI >/= 40 kg/m2 or between 35– 40 kg/m2 and other significant disease (for example, type 2 diabetes, hypertension) that could be improved with weight loss.
- All non– surgical measures have failed to achieve or maintain adequate clinically beneficial weight loss for at least 6 months.
- They are generally fit for anaesthesia and surgery
- They commit to the need for long– term follow– up
- First– line option for adults with a BMI > 50 kg/m2 in whom surgical intervention is considered appropriate; consider Orlistat if there is a long waiting list.
Types of bariatric surgery
Banding- laparoscopic reversible, slower WL
Bypass- jejunum bypass stomach but duodenum attached - greater WL, irreversible, B12 def in 50%
Sleeve gastrectomy-
Resection of stomach using stapling devices
* Body and fundus resected to leave a small section of stomach
Quadrate lobe borders
Porta hepatis lies behind
On the right lies the gallbladder fossa
On the left lies the fossa for the umbilical vein- ligamentum teres
Caudate lobe borders
-Lies behind the plane of the porta hepatis
* Anterior and lateral to the inferior vena cava
* Bile from the caudate lobe drains into both right and left hepatic ducts
- ligamentum venosum to left
Falciform ligament attachments and origin
2 layer fold peritoneum from the umbilicus to anterior liver surface
* Contains ligamentum teres (remnant umbilical vein)
* On superior liver surface it splits into the coronary and left triangular ligaments(which attach to diaphragm)
Ligamentum venosum
Remnant of ductus venosum- which allowed bypassage of liver
Sits posteriorly to left of caudate
Types of benign liver lesions
Haemangioma- most common of mesenchyme origin
Separated from liver by fibrous tissue
Hyperechoic US
Adenoma- women, OCP, hypotenuse on CT
Abscess- RUQ pain, fever, jaundice
Amoebic- fever, RUZ- US fluid filled poorly defined boundaries
Aspiration- anchovy paste- metronidazole
Hydatid- daughter-fibrotic reaction surrounding, mebendazole + surgical resection
Polycystic- PKD
What should be avoided with HCC
Liver biopsy
Liver biopsy of alcholic hepatitis
Mallory bodies
If CBD distended before operation
ERCP before operation- try to clear the duct by ERCP,sphincterotomy
Then operation later date
PSC vs PBC vs AIH
PSC- ulcerative colitis
Onion skin fibrosis
Intra and extra hepatic ducts
pANCA
PBC- Anti Mitochondiral AB
intra
IgM
Granuloma
CREST syndrome
AIHA- ANA SMA (1); Anti-Liver Kidney Microsome type I antibody (2)
CBD relations at origin
Medially- hepatic artery
Posterior- portal vein
CBD relations distally
- Duodenum - anteriorly
- Pancreas - medially and laterally
- Right renal vein - posteriorly
Features making each gall stone more likely
Multiple- mixed, Ca
Cholesterol- solitary
Bile- haemolytic anaemia, black
Outpouching in chronic cholecystiticits
Aschoff-Rokitansky Sinuses
→ These are outpouchings of GB mucosa into the GB muscle layer and subserosal tissue
→ Result of hyperplasia and herniation of epithelial cells through the fibromuscular layer of the GB wall.
→ They are usually referred to as Adenomyomatosis
Absolute Contraindication of Lapchole
- VwB disease
– Abdominal sepsis
– Late pregnancy
Mirizzi syndrome
Common hepatic duct obstruction caused by extrinsic compression from an impacted stone in the cystic duct or infundibulum of the gallbladder
Most frequent organisms causing cholangitis
Escherichia coli Klebsiella species Enterococcus species Streptococcus species
Ix for cholecystitis
USS: 1st line
MRCP if any inconclusion
Cholangitis ix
USS
ERCP gold standard
Mx of biliary atresia
Roux-en-Y portojejunostomy (Kasai procedure)
When is pancreatitis severe on Glasgow scale
3 or more
Pancreatitis sequelae
Peripancreatic fluid collection- Located in or near the pancreas and lack a wall of granulation or fibrous tissue
Pseudocyst- collection is walled by fibrous or granulation tissue (lack an epithelial lining)and typically occurs 4 weeks or more after an attack of acute pancreatitis
Elevated amylase
Investigation is with CT, ERCP and MRI or Endoscopic USS
* Symptomatic cases may be observed for 12 weeks as up to 50% resolve
* Treatment is either with endoscopic or surgical cystogastrostomy or aspiration
Pancreatic necrosis- nvolve both the pancreatic parenchyma and surrounding fat- Radiological drainage or surgical necrosectomy.
Abscess
Haemorrhage
Ix and mx of pancreatic necrosis
CT - FNA If definitive needed
Pancreatic necrosectomy (open or endoscopic)
Systemic complications of pancreatitis
Disseminated Intravascular Coagulation (DIC)
Acute Respiratory Distress Syndrome (ARDS)
Hypocalcaemia
Fat necrosis from released lipases, results in the release of free fatty acids, which react with serum calcium to form chalky deposits in fatty tissue
Hyperglycaemia
Mx of acute pancreatitis
DCC
Fluid resus
NG tube
Catheterisation
Opioid analgesia
Broad spectrum ABx
Main cause of chronic pancreatitis
chronic alcohol abuse (60%) and idiopathic (30%).
Presentation of chronic pancreatitis
Chronic abdominal pain, however may also develop malabsorption, diabetes mellitus,
Ix of chronic pancreatitis
Serum amylase or lipase levels are often not raised
A faecal elastase level will be low
CT- pancreatic atrophy or calcification, as well as any pseudocysts present
Mx of chronic pancreatitis
enzyme replacement (including lipases), such as Creon®
fat-soluble vitamins (A, D, E and K), tand check bone density routinely.
Those with pancreatogenic diabetes may benefit insulin regimes, along with annual surveillance with HbA1c.
Where does pancreatic cancer occur and where does it often spread to
Head
Liver
Mx of pancreatic cancer in head and tail
Head- Whipples procedure
Dumping and ulcers
Tail- distal pancreatectomy and splenectomy with regional lymphadenectomy
All surgical patients should receive adjuvant chemotherapy
Sx of pancreatic cancer
WL
Painless jaundice
Trousseaus sign- Migratory superficial thrombophlebitis
Abdominal pain (non-specific) – due to invasion of the coeliac plexus or secondary to pancreatitis
Endocrine Tumours of the Pancreas
Gastrin-g- Zollinger Ellison
Glucagon-a- hyperglycaemia, necrolytic migratory erythema
Insulin-b- hypoglycaemia
SS-d- inhibits GH, TSH, prolactin- DM, steathorrea, gallstones (due to CCK inhibition)
VIP- non islet cells- normal secrete water and electrolytes into gut with relaxation-
Prolonged diarrhoea, severe hypokalaemia (verner Morrison syndrome)
Sx of insulinoma
Whippples triad
- Hypoglycaemia symptoms during fasting - ↓ FBS
- low glucose
- Symptoms relieved by i/v Dextrose
VIPoma sx
Wa : Watery
D Diarrhoea (Octreotide therapy gives prompt relief from diarrhea.)
H : Hypokalamia
A : Achlorhydria- no acid
Where are most of gastrinomas found
In gastrinoma triangle:
Superior- CBD
2/3rd part of duodenum (inferior)
Neck and body of pancreas (medial)
Mx of Zollinger Ellison syndrome
Octreotide- suppressing gastrin
Most gastrinomas in the pancreas can be removed by enucleation, and large tumors can be removed by
resective procedures.
What tissue is spleen derived from
Mesenchyme
What is in close relation to pancreatic tail
Splenic hilum
Ligaments of spleen and what is contained within them
Gastrosplenic- short gastric , Left Gastro-Epiploic Vessels
Splenorenal- tail of the pancreas. splenic artery. splenic vein.
Function of spleen
FISH
F iltration of encapsulated organisms and blood cells I mmunological function
S torage of platelets
H aematopoiesis in the foetus
Indication of splenectomy
- Trauma: 1/4 are iatrogenic
- Spontaneous rupture: EBV
- Hypersplenism: Hereditary Spherocytosis or Elliptocytosis - causing anaemia
- Malignancy: Lymphoma or Leukaemia
- Splenic Cysts, Hydatid Cysts, Splenic Absces
Cell changes after splenectomy
PLATELETS WILL RISE FIRST
- Immediately - Agranulocytosis (mainly Neutrophils), which is replaced by a Lymphocytosis & Monocytosis over the following weeks.
- In First Few Days - Target Cells, Siderocytes & Reticulocytes will appear.
- over Following Weeks - Cytoplasmic Inclusions seen e.g., Howell Jolly Bodies
. - Other changes include Target Cells and Pappenheimer bodies
Complications of splecentomy
- Haemorrhage (may be early and either from Short Gastric or Splenic hilar vessels)
- Pancreatic fistula (from iatrogenic damage to pancreatic tail)
- Thrombocytosis: Prophylactic aspirin
- Encapsulated bacterial infection
Gross pathology of ulcers
50% <2cm
Oval with straight walls
Smooth base
histology of ulcers
1- superficial necrotic fibrinoid
2- active cellular nets infiltrate
3- granulation
4- fibrocartilingeous scar, arteries thick and thromboses
When to use surgery for ulcer
If perf or massive haemorrhage
Non resolving or relapsing
> 3cm - medical not working for 6-8w
SE of vagotomy
Obstruction
Gallstones
Vomiting
Diarrhoea
Dumping syndrome
IDA
B12 def
Tx of perforated small stomach ulcer
Excisions and closure
Due likely being malignant
If larger- total or partial gastrectomy
H pylori appearance
Gram neg
Flagellated spiral bacillus
Urease enzyme
H pylori test and mx
Urea breath test or stool antigen
If test neg- PPI for 1/2 months until ulcer healed
Positive- PPI + amor 1g/met 400mg + clarith 500mg 7d
Factors assessed in blatchford score
Urea
Hb
SBP
Pulse
CO morbidities- melena, syncope, hepatic disease, HF
PHUCS
Factors Rockall score asseses
Age
Shock-BP/pulse
Source of bleeding
Comorbidities
Stigmata of recent bleeding- e.g clots
mx of UGI haemorrhage
Endoscopy- <24hrs presentation
Adrenaline injections- 4 quadrant
Clips, bipolar
Then pharm therapy- pH >6, eradication of H pylori
Indications of surgical tx bleeding ulcer
Continue bleeding
1 rebleed, 2 if <60
> 50 requiring 4U of blood
<50 6U in 24 hrs
Surgical mx of bleeding ulcer
Underunning vessel with suture
Peptic- excision if on greater curve
Gastrotomy if lesser
Duodenal - duodenotomy then vagotomy and pyloroplasty
Ulcer perforation tx
Laparotomy
Gastric- greater curve- ulcer excision and closure with omental patch
Lessier- distal- billroth
Proximal- subtotoal
Duodenal - simple closure with mental patch and peritoneal lavage
Presentation of gastric outlet obstruction
Projectile of undigested food
Epigastric pain
Electrolyte imbalance
Palpable stomach
Mx of gastric outlet obstruction
Correct fluid and electrolyte imbalance
Endoscopy- diagnostic and enable balloon dilation
Surgical- gastroenterostomy
What increases risk of gastric carcinoma
Chronic atropic gastritis
Men
Pernicious anaemia
H pylori
Microscopic feature of gastric carcinoma
All adenocarcinoma
Intestinal - malignant glands
Diffuse- small malignant cells- better prog
Signet- large vacuole of mucin - worse prog
Diagnosis of gastric carcinoma
Endo wits biopsy
Staging with CT