A & P - Respiratory system Flashcards

1
Q

name the 3 lobes and 2 fissures of the right lung

A
lobes - superior
-middle
-inferior
fissures - oblique
- horizontal
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2
Q

name the 2 lobes and 1 fissure of the left lung

A

lobes - superior
- inferior
fissure - oblique

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3
Q

where can the visceral pleura be found?

A

covering the lungs - passes into fissures

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4
Q

where can the parietal pleura be found?

A

lining the chest wall - continuous with visceral pleura around hilum

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5
Q

what is the space between the parietal and visceral pleura called?

A

pleural cavity - filled with serous fluid

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6
Q

the respiratory system has two zones, name them and say what they consist of

A

conducting zone -
nose, pharynx, larynx, trachea, bronchi, bronchioles, terminal bronchioles
respiratory zone -
respiratory bronchioles, alveolar ducts, alveolar sacs, alveoli

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7
Q

what does the upper respiratory tract consist of?

A
nose
nasal cavity
paranasal sinuses
pharynx
larynx
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8
Q

what does the lower respiratory tract consist of?

A

trachea
bronchi
bronchioles
alveoli

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9
Q

name three important areas of the nasal cavity

A

conchae
meati
paranasal air sinuses

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10
Q

what are the functions of the nasal cavity?

A

warm, cleanse and humidify air
detect odour
resonating chamber

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11
Q

describe the structure and function of the conchae in the nasal cavity

A

S- ridges in cavity increase surface area, cause turbulence

F - warming, humidifying, filtering air

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12
Q

describe the structure and function of the sinuses in the nasal cavity

A

S- tiny bone cavities

F - speech, lighten skull

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13
Q

name the four sinuses in the nasal cavity

A

maxilla
sphenoid
frontal
ethemoidal

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14
Q

name the three sections of the pharynx

A

nasopharynx
oropharynx
laryngopharynx

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15
Q

what is the function of the pharynx?

A

passage for air and food (mucus too)
warm and humidify air
resonating chamber
protection

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16
Q

what does the larynx consist of?

A

epiglottis

thyroid cartilage

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17
Q

what are the functions of the larynx?

A

route for food and air
protects airway
triggers cough reflex
vocal folds vibrate with expelled air

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18
Q

what is the wall of the larynx composed of?

A

9 pieces of cartilage

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19
Q

what is the trachea made of?

A

cartilaginous c shaped rings

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20
Q

what does the open part of the cartilaginous c shaped rings in the trachea abut?

A

oesophagus

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21
Q

describe the respiratory mucosa

A

pseudo stratified ciliated columnar epithelium

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22
Q

what function does the muco-ciliary escalator have?

A

moves dust particles and debris with mucus out of lungs

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23
Q

in which direction does the muco-ciliary escalator move mucus? in the upper and lower respiratory tract?

A

upper: down towards pharynx
lower: up towards pharynx

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24
Q

what does the bronchial tree consist of?

A
trachea
primary bronchi
secondary bronchi - 3 r/lung, 2 l/lung
tertiary bronchi
bronchioles
terminal bronchioles
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25
Q

which primary bronchi is most likely to have an object lodged in it and why?

A

right - its shorter

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26
Q

what does a bronchus have that a bronchiole does not?

A

cartilage rings or plates

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27
Q

do bronchioles have cilia?

A

no

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28
Q

what are bronchioles made of and which system controls them?

A

smooth muscle controls by ANS

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29
Q

describe which membranes oxygen diffuses through to get from the alveoli to the capillary

A

squamous epithelial cell then basement membrane then capillary epithelium

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30
Q

what makes up the alveoli wall?

A

type I alveolar cell -squamous epithelium

type II alveolar cells - septal cells

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31
Q

what carries deoxygenated blood to the lungs?

A

pulmonary arteries

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32
Q

what carries oxygenated blood to the heart?

A

pulmonary veins

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33
Q

what supplies the lung tissue with blood?

A

bronchial arteries

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34
Q

what is pulmonary ventilation?

A

exchange of air between atmosphere and alveoli

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35
Q

what is involved in quiet inspiration?

A

diaphragm - 80%

external intercostal muscles - 20%

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36
Q

what happens during quiet expiration?

A

diaphragm moves upwards
ribs move down
sternum moves in

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37
Q

what muscles are involved in forced inspiration?

A
scalenes
sternocleidomastoid
pectoralis minor and major
internal intercostals
rectus abmoninis
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38
Q

what muscles are involved in forced expiration?

A

internal intercostals
oblique and rectus abmoninis muscles
quadratus lumborum

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39
Q

what is atmospheric pressure?

A

pressure exerted by the air and gases surrounding the body

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40
Q

what is intrapleural pressure?

A

opposing forces

recoil vs. elasticity of chest wall

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41
Q

what is created between the pleural membranes in health?

A

a vacuum - negative intrapleural pressure created which stops lungs from collapsing

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42
Q

what should intrapleural pressure be in relation to intra pulmonary pressure?

A

4mmHg less

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43
Q

during expiration what happens to pressure?

A

increases - as pulmonary cavity gets smaller

44
Q

during inspiration what happens to pressure?

A

decreases - as pulmonary cavity gets bigger

45
Q

when does air stop entering the lungs?

A

when intra pulmonary and atmospheric pressure is equal

46
Q

when does air leave the lungs?

A

when intra pulmonary pressure is more that atmospheric pressure

47
Q

what is pulmonary compliance?

A

ease with which lungs expand

48
Q

what is high pulmonary compliance?

A

lungs/ thoracic wall expands easily

lungs are elastic and have adequate surfacent

49
Q

what is low pulmonary compliance?

A

lungs resistant to expansion

50
Q

what is pulmonary compliance reduced by?

A
scar tissue on lungs
difficulty expanding lungs
blockage of resp. passage
low level of surfacent
high surface tension
51
Q

what regulates the diameter of airways?

A

smooth muscle

52
Q

in disease/illness such as asthma or COPD what happens to the bronchioles?

A

they can’t expand fully due to increased airflow resistance

53
Q

name some pulmonary function tests

A

spirometer - measures amount of air entering/ leaving lungs
respiratory volumes
respiratory capacities - combo of different resp. volumes

54
Q

what do the following abbreviations stand for?
IVR
VT
EVR

A

IVR - inspiratory reserve volume
VT - resting tidal volume
EVR - expiratory reserve volume

55
Q

what are the normal IVR values for men and women?

A

men - 3300

women- 1900

56
Q

what are the normal VT values for men and women?

A

both - 500

57
Q

what are the normal EVR values for men and women?

A

men - 1000

women - 700

58
Q

what is forced vital capacity (FVC)?

A

deep breath followed by rapid maximal exhalation

59
Q

FVC and FEV (forced expiratory volume in a second) at used to diagnosis what? and what are the healthy and abnormal levels?

A

obstructive disorders eg. asthma
FEV/FVC x 100
>70% healthy
<70% asthma

60
Q

what is Dalton’s law of partial pressure?

A

in mixture of gases each gas exerts its own pressure as if the other gases where not there

61
Q

what is partial pressure?

A

pressure exerted by each gas

62
Q

how can you work out the partial pressure?

A

% of gas in mixture x total pressure of mixture =partial pressure

63
Q

describe the solubility in plasma of CO2, O2 and N2

A

CO2 has a greater solubilty than O2 in plasma

O2 has a much greater soulilty than N2 (nitrogen) in plasma

64
Q

what is Henry’s law?

A

amount of gas that dissolves in water is determined by its solubility in water and its partial pressure in air

65
Q

describe the relative partial pressures and solubility of CO2 and O2

A

partial pressure of O2 is greater than CO2

solubility of CO2 is greater than O2

66
Q

the exchange of Co2 and O2 must be what in the respiratory system?

A

equal

67
Q

what does CO2 rely on to make its exchange with O2 equal?

A

its greater solubility than O2 in plasma

68
Q

what does O2 reply on to make its exchange with CO2 equal?

A

its greater partial pressure than CO2

69
Q

down which gradient do gases diffuse?

A

pressure gradient

70
Q

what % of oxygen binds to haemoglobin?

A

98.5%

71
Q

how many molecules of oxygen can each haeme carry?

A

4

72
Q

what % of oxygen is carried in plasma?

A

1.5%

73
Q

if the partial pressure of oxygen is greater what happens?

A

more oxygen will combine with haemoglobin until saturated

74
Q

if the partial pressure of oxygen is lower what happens?

A

haemoglobin doesn’t hold as much oxygen

75
Q

how does the partial pressure in the alveoli and systemic tissues affect the amount of O2 bound to haemoglobin?

A

partial pressure in alveoli is greater so more oxygen bound

partial pressure in tissues is lower so less oxygen is bound

76
Q

what influences the amount of oxygen that the blood will give up?

A

partial pressure in that area

77
Q

name 5 factors that influence haemoglobin saturation

A
  • carbon dioxide
  • temp
  • acidity of blood
  • 2, 3- diphosphoglycerate
  • structure of Hb
78
Q

how does carbon dioxide influence Hb saturation?

A

increased CO2 cause blood to release oxygen allowing CO2 to bind

79
Q

how does acidity of blood affect Hb saturation?

A

increased acidity lowers O2 affinity with Hb.

80
Q

how does temperature affect Hb saturation?

A

increased temperature means more O2 are released from Hb

81
Q

how does 2,3- diphosphoglycerate (DPG)

affect Hb saturation?

A

reduces affinity of oxygen to Hb - it is produced during glycosis

82
Q

why does foetal Hb have a greater affinity to O2?

A

it binds 2,3- diphosphoglycerate (DPG) less strongly

83
Q

what % of CO2 is dissolved in plasma?

A

~ 7%

84
Q

what % of CO2 is bound to Hb in RBCs?

A

~ 23% - binds to globin peptide chains

85
Q

where is the highest % of CO2 found in the blood?

A

as bicarbonate (HCO3-) ion in plasma (~ 70%)

86
Q

what happens if Co2 level in blood increase?

A

more CO2 moves out of RBCs

87
Q

what happens if Co2 level in blood decrease?

A

more CO2 moves into of RBCs

88
Q

how much oxygen and carbon dioxide are exchanged from the alveolar air to RBCs and vice versa? and in which direction?

A

carbon dioxide - 100% from RBC to alveolar

oxygen - 100% from alveolar to RBC

89
Q

how much oxygen and carbon dioxide are exchanged from respiring tissue to capillary blood and vice versa? and in which direction?

A

carbon dioxide - 100% from tissue to RBC in capillary

oxygen - 100% from RBC in capillary to tissue

90
Q

name the two pontine respiratory centre

A

apneustic centre

pneumotaxic centre

91
Q

what is the function of the apneustic pontine centre

A

activates and prolongs inspiration

92
Q

what is the function of the pneumotaxic pontine centre

A

increase breathing rate

turns off inspiratory area before lungs overfill

93
Q

name the two areas of the medulla involved with respiration

A

ventral respiratory group (VRG)

dorsal respiratory group (DRG)

94
Q

what are the functions of the VRG and DRG?

A

VRG - accessory muscles of inspiration and expiration

DRG - active during inspiration, modifies rhythm of VRG

95
Q

what factors affect the rate and depth of breathing?

A

change in body demands
altitude
disease
changing levels in atrial blood : eg CO2, H+, O2

96
Q

which is the most important factor within the atrial blood which is monitored by the body to alter respiration?

A

CO2

97
Q

how does the body detect increases CO2 in blood?

A

increased CO2 leads to increased H+, raising blood acidity. This acidity id detected by chemoreceptors

98
Q

what is likely to happen to blood acidity in respiratory disease such as emphysema?

A

CO2 levels will increase, then H+ level increase. Partial pressure of CO2 increases thus blood becomes acidic leading to respiratory acidosis

99
Q

what happens if a patient is O2 when the partial pressure of CO2 is increased?

A

partial pressure of CO2 increases further, then chemoreceptors respond to increased H+, returning the PaCO2 to normal by increased ventilation and exhaling more CO2

100
Q

what is hypoxic drive? often seen in COPD patients?

A

CO2 in retained so chemoreceptors adapt to increased paCO2

101
Q

where are the peripheral chemoreceptors located?

A

aortic bodies

carotid bodies - main O2 receptors

102
Q

where are the central chemoreceptors located?

A

surface of medulla - primarily monitor pH of CSF

103
Q

what % of change is mediated by the peripheral and central chemoreceptors in response to changes in CO2?

A

peripheral - 30%

central - 70%

104
Q

what happens if paCO2 decreases?

A

blood acidity levels decrease and blood pH rises, leading to respiratory alkalosis

105
Q

what might cause respiratory alkalosis?

A

hyperventilation or panic attack

106
Q

what happens if the paO2 increases?

A

free radials are generated leading to coma and death

107
Q

what happens if paO2 decreases?

A

atrial paO2 must be below 60mmHg,

then increased ventilation, central chemoreceptors switch off and peripheral chemoreceptors increasing breathing rate