A & P - reproductive systems Flashcards
what are the functions of the male reproductive system?
introduce male gamete to female repro. tract
produce androgens
production, storage and nourishment of male gametes
what does the male reproductive system consist of?
testes scrotum ducts glands penis
name the 3 ducts of the male reproductive system
epididymal duct
vas (ductus) deferens
urethra
name 3 glands of the male reproductive system
bulbourethral
seminal vesicles
prostate
what are the dimensions of the testes?
4cm long x 2.5cm diameter
what separates the 2 compartments of the scrotum?
scrotal septum
what is the raphe?
median ridge which separates scrotum externally
what is each testis suspended by?
spermatic cord
what does the spermatic cord pass through?
inguinal canal - diagonally form/to abdominal cavity
what does the spermatic cord contain?
vas (ductus) deferens testicular artery cremasteric artey cremaster muscle testicular venous plexus lymph vessels nerves
how many lobules does each testis have?
300
what divides the testis into lobules?
tunica albuginea
how many seminiferous tubules does each lobule in testis contain?
1 to 4
where does spermatogenesis occur?
seminiferous tubules
what is spermatogenesis?
creation of spermatozoa
what forms the walls of the seminiferous tubules?
Sertoli (sustentacular) cells
what is the function of the sertoli cells?
secrete nutrients for spermatozoa
what are in the wall of the seminiferous tubules?
spermatogenic cells
where in the wall of the seminiferous tubule are mature cells most likely to be?
near lumen - ready to be released
what is mitosis?
division of a parent cell into 2 identical daughter cells
what is meiosis?
occurs in germ cells to produce gamete - number of chromosomes reduced to 23 pairs
what is spermiogensis?
converts spermatids to spermatozoa
when does meiosis I occur in males?
at puberty
how many spermatids are created from 1 germ cell?
4
describe the structure of spermatozoa
head - nucleus (DNA), acrosome (enzymes)
middle piece - mitochondria (power)
tail - flagellum (movement)
what are sertoli cells in seminiferous tubules needed for?
maturation of spermatozoa - support & nourish
release spermatozoa into lumen
produce fluid to transport spermatozoa
what are leydig cells in seminiferous tubules needed for?
secretion of androgenic steroids (eg. testosterone)
what is the blood-testis barrier in seminiferous tubules needed for?
to stop blood and sperm cells mixing - could cause immune response
what do sertoli cells in seminiferous tubules secrete?
inhibin
androgen binding protein
mullerian-inhibiting substance
what is the structure of the sertoli cell?
tall columnar polymorphic cells
what temperature do the testes need to be?
35c
which muscle draws the testes closer to the body?
cremaster muscle
which muscle is used to decrease surface area of the testes by wrinkling skin?
dartos muscle
where does heat exchange take place to cool the testes?
pampiniform plexus (venous plexus)
secretions from the leydig cells in seminiferous tubules causes what to develop?
the secondary sexual characteristics (eg. public hair)
where are spermatozoa matured?
in the tail of epididymus
name the ducts which join the seminiferous tubules to the urethra
straight seminiferous tubules rete testis epididymal duct vas (ductus) deferens ejaculatory duct ureathra
describe the structure of the vas deferens
45cm long fibromuscular tube.
a narrow lumen surrounded by thick muscle
what are the functions of the vas deferens?
stores and conveys spermatozoa
how does the vas deferens enter the abdominal cavity?
through inguinal canal
describe the route the vas deferens takes
medial to ureter and superior, then posterior to bladder
what is the dilated terminal end of the vas deferens called?
ampulla
how are spermatozoa expelled from vas deferens?
peristalsis
what are stereocilia? and what is their function?
microvilli in the vas deferens which absorb dead/damaged sperm
where is the vas deferens cut in a vasectomy?
near epididymis
name the 3 accessory glands of the male reproductive system
seminal vesicle
prostate
bulbo-urethral
describe the structure of the seminal vesicle
convoluted muscular gland
5cm long
posterior to bladder
joins vas deferens to form ejaculatory duct
what does the seminal vesicle secrete?
alkaline- nutrients (fructose) containing secretion
what volume of the semen does the secretion from the seminal vesicles account for?
60%
describe the structure of the prostate gland
4cm x 3cm x 2cm
inferior to bladder
surrounds prostatic urethra
what is the function of secretion from the prostate gland and what volume do they account for in semen?
assist sperm motility
25% of semen volume
what is the name for an enlarged prostate?
benign prostatic hyperplasia
what are the symptoms of benign prostatic hyperplasia?
increase frequency of urination
nocturia urgency
hesitancy
weak stream
what are the treatments for benign prostatic hyperplasia?
alpha androgenic blockers - Alfuzosin
5-alpha reductase inhibitor - Finasteride
what is prostatitis?
inflammation of the prostate - acute (bacterial) or chronic (unknown)
what are the symptoms of prostatitis?
painful urination and ejaculation
discomfort in pelvis
what are the treatments of prostatitis?
antibiotics
alpha inhibitors
what test can be performed to diagnosis prostate cancer?
prostate - specific antigen blood test
why does prostate cancer often metastasize?
its connected to the venous plexus
describe the structure of the bulbo-urethral glands
1cm in diameter
lined by mucus secreting epithelium
produced mucus like secretion during arousal
neutralises urine residue
describe the structure of the urethra
20cm long
3 parts: prostatic part, membranous part, spongy part
name 3 regions of the penis
root, shaft, glans penis
where does the bulb of the penis attach?
inferior to the surface of urogenital membrane - becomes corpus spongiosum
where does the crura of the penis attach
roof of the penis to pubic arch - becomes corpus cavernosa
what is the shaft of the penis bound by?
tunica albugina
what forms the glans penis?
tip of corpus spongiosum
what partially covers the glans penis and urethral orifice?
prepuce
what causes the arteries to dilate during an erection?
parasympathetic impulses
what do the endothelium cells in the penis produce during an erection?
nitric oxide - causes smooth muscle to relax
what impulses cause ejaculation?
sympathetic impulses
contraction of the smooth muscle in the penis allows secretions from where?
epididymal duct
vas deferens
prostate
seminal vesicles
what is emission in relation to the penis?
small amount of seminal fluid released before ejaculation
what causes ejaculation?
contraction of bulbospongiosus muscle (also compresses urethra)
what is the inguinal canal a pathway for?
descending testes
what is cryptorchidism?
when testes don’t descend
when do testes usually descend?
7-8months of pregnancy
what is an inguinal hernia?
a weakness in the wall of the inguinal canal causes by descend of testes
also caused by intra abdominal pressure
how much semen is there in each ejaculation?
2-5ml
how many sperm are present per ml of semen?
20-100 million
how much of the volume of each ejaculate is sperm?
less than 1%
what does semen consist of?
sperm
seminal fluid
enzymes
what is oligospermia?
low sperm count
name the external genitalia of the female reproductive system
mons pubis
labia
clitoris
name the internal genitalia of the female reproductive system
ovaries
fallopian tubes
uterus
vagina
describe the structure of the ovary
4cm x 2cm x 1cm
lies on surface of broad ligament
how is the ovary attached to the abdominal wall
by the suspensory ligament
what attaches the ovaries to the uterus?
ligament of ovary
what is the broad ligament made of?
peritoneum
the uterus is sandwiched between two layers of what?
broad ligament
what is the outer most layer of the ovary?
germinal epithelium
what is the inner most layer of the ovary?
cortex - ovarian follicles and stromal cells
what enters the ovary at the hilum?
neurovascular supply
autonomic nerve fibres - from ovarian plexus
lymphatic drainage
ovarian arteries
when does mitosis of sperm begin?
in puberty
when does mitosis of ovum complete?
in foetal life
when does meiosis of ovum begin and complete?
begins in foetal life but only complete if ovum is released during an ovulation cycle
when does meiosis II complete in females?
only if the ovum is fertilised
name the 4 parts of the fallopian tube
infundibulum - closest to ovary
ampulla
isthmus
intramural segment - continuous with wall of uterus
describe the functions of the fallopian tubes
convey oocyte from peritoneal cavity to uterus
convey spermatozoa to fertilisation site
where is the oocyte usually fertilised?
ampulla
describe the structure of the fallopian tube
10cm long highly convoluted interior muscular tube ciliated simple columnar epithelium secretory cells
what are fimbriae?
finger like projections at the ovary end of the fallopian tube - produce currents
how does the oocyte move along the fallopian tube?
cilia and peristalsis
when does fertilisation usually occur?
24hrs post ovulation - 3-4 days for egg to move through fallopian tube
describe the structure of the uterus
inverted pear
7.5cm x 5cm x 2.5cm
describe the position of the uterus
flattened antero-posteriorly
superior to bladder
tilted (anteverted) and bent (anteflexed) anteriorly
which ligament attaches the uterus to the sacrum?
utero-sacral
which ligament attaches the uterus to the cavity?
cardinal
which ligament attaches the cervix to pubic mound?
pubo-cervical fascia
name the 3 parts of the uterus
fundus
body
cervix
which pouch in the abdominal cavity is the lowest point?
rectouterine pouch (pouch of Douglas)
name the pouches of the abdominal cavity
rectouterine
vesicouterine
what occurs in the functional zone of the uterus?
structure changes dramatically through cycle shed monthly (28 days)
what occurs in the basal zone of the uterus?
not shed
provides cellular reserve for re-growth of functional layer
name the 2 areas of the cervix
endocervix
ectocervix - continuous with vagina
where in the cervix does the epithelium change?
squamo-columnar junction
what happens to the position of the cervix at puberty?
it moves inferiorly into vagina
what is the transformation zone in the cervix?
area where columnar may change to squamous epithelium
how long does the menstrual phase of the menstrual cycle last?
between days 1 and 5 - spiral arteries constrict, functional layer sloughed off
on which days of the menstrual cycle does the proliferative phase occur?
days 6 - 14 - oestrogen controlled, build up of tissue and glands
on which days of the menstrual cycle does the secretory phase occur?
days 15 -28 - progesterone controlled, glands enlarged, spiral arteries coil
what is metaplasia relating to the cervix?
change of one cell type to another
what are the characteristics of carcinoma?
dense, dark, irregular cells
what is dyplasia relating to the cervix?
cells which are beginning to look abnormal
describe the structure of the vagina
8cm long
fibromuscular tube
lined with stratified squamous epithelium
mucosa arranged in rugae
why is the vagina acidic?
decomposition of glycogen
what is the mons pubis?
fatty pad over pubic symphysis
what are the labia majora?
prominent skin folds
what are the labia minora?
skin enclosing urethral and vaginal orifices
meet at clitoris and fourchette
what is an episiotomy?
mediolateral incision from fourchette
what is the function of the pelvic floor?
support pelvic contents
what does the pelvic floor form?
roof of perineum
what muscles make up the pelvic floor?
coccygeus and levator ani muscles
what does the mammary gland consist of?
adipose tissue
glandular tissue
fibrous tissue
during pregnancy progesterone stimulates what in the mammary glands?
secretory alveoli
Prolactin released from the anterior pituitary does what in the mammary glands?
stimulates alveoli cells to synthesis milk proteins and lipids
oxytocin released from the posterior pituitary gland stimulates what in the mammary glands?
ejection of milk with help from myoepithelial cells contracting
name some lymph nodes in the mammary gland
apical lymph node
central lymph node
subscapular lymph node
pectoral lymph node
what functions does hormonal control play in the female reproductive system?
control menstrual cycle
controls ovulation
prepares uterus for implantation
which cells secrete follicular fluid?
granulosa cells
what is a follicle?
ovum and follicular cells
what is the function of FSH in the female reproductive system?
- stimulates growth and development of follicles
- promotes ovaries to secrete oestrogen - stimulates LH receptors on granulosa cells
- promotes secretion of inhibin by ovaries (this inhibits FSH)
what can’t happen without LH surge in the female reproductive system??
ovulation
what is the function of LH in the female reproductive system?
induce ovulation
formation of corpus luteum
how is the follicle released from the ovary?
- increased LH increases collagenase activity (this digested collagen fibres surrounding follicle)
- prostaglandin levels increase (cause contraction of ovary wall)
how is the corpus luteum formed?
after follicle ruptures releasing oocyte it collapses and granulosa cells invade area.
what does the corpus luteum secrete?
progesterone to maintain pregnancy
what happens to the corpus luteum if fertilisation of oocyte does not occur?
degrades around 12hrs post ovulation
progesterone and oestrogen levels fall
fibroblasts invade CL (corpus albicans)
disintegration marks end of ovarian cycle
what happens to the corpus luteum if fertilisation of oocyte does occur?
future placenta tissue secretes hCG
hCG maintain CL
after 2 months oestrogen and progesterone level maintain pregnancy without CL
what is the function of progesterone in the female reproductive system?
prepares for pregnancy
glands coil in endometrium and accumulate glycogen
spiral arteries grow towards surface
cervical mucus thickens
how does the combined pill work?
progestin (mimics progesterone) and oestrogen - feeds back to inhibit LH and GnRH
what is the average age of menopause?
52yrs
why does menstruation cease in menopause?
decreased oestrogen levels
what are then risks of using HRT?
increased thromboembolism and ovarian cancer
what is the pH of the vagina?
4.3
what is the pH of the cervix?
6-6.5
how does the semen protect the sperm from the hostile environment of the vagina?
it has a buffering effect -( increasing the pH to 7.2 within 10secs)
cervical mucus is not readily penetrable, how does the sperm get through?
the water content of cervical mucus increases in days 9-16.
where does the head of the spermatozoa bind to during fertilisation?
zona pellucida
what is polyspermy and how is it prevented during fertilisation?
more than one sperm fertilising the ovum.
rapid depolarisation stops other sperm entering ovum
how many cells are present in the ovum 5 days post fertilisation and what are the cells called?
107 cells
blastocyst
what are the inner cells f the blastocyst called?
embryoblast
what are the outer cells f the blastocyst called?
trophoblast - form placenta
when does implantation of the blastocyst occur?
8 days post fertilisation
where does the blastocyst implant?
within the stroma
name different types of ectopic pregnancy
abdominal tubal (isthmic or ampullar) infundibular ovarian interstitial cervical