9 Molecular mechanism of pain

Question 1

Give the definition of Nociceptor

Answer 1

High-threshold sensory receptor of peripheral somatosensory nervous system capable of transducing and encoding noxious stimuli

Question 2

Give the definition of Hyperalgesia

Answer 2

Increased pain from a stimulus that normally provokes pain

Question 3

Give the definition of Neuropathic pain

Answer 3

Pain caused by a lesion or disease of somatosensory nervous system

Question 4

Give the definition of Allodynia pain

Answer 4

Due to a stimulus that does not normally provoke pain

Question 5

Give the definition of Sensitization

Answer 5

Increased responsiveness of nociceptive neurons to their normal input, and/or recruitment of a response to normally sub-threshold inputs

Question 6

What are the 2 main types of Nociceptive pain?

Answer 6

Somatic and Visceral

Question 7

What are the main components of nociceptive process?

Answer 7

(1) Nociceptors
(2) Primary afferent neurons
(3) Spinal cord
(4) Secondary afferent neurons
(5) Brain

Question 8

What channel is expressed in heat-sensitive afferents?

Answer 8

TRPV1

Question 9

What channel is expressed in cold-sensitive afferents?

Answer 9

TRPM8

Question 10

What is the thermal pain threshold for heat?

Answer 10

43 degree

Question 11

What is the thermal pain threshold for cold?

Answer 11

25 dgree