15 Molecular architecture of neuronal synapse

Question 1

What are the signaling molecules that regulate the initiation of dendritic filopodia?

Answer 1

(1)Neurotransmitters
(2)Membrane-associated proteins
(3)Nucleation promoting factor(NPFs)

Question 2

What is postsynaptic density?

Answer 2

It is a huge protein complex associated with postsynaptic membranes of excitatory
synapses

Question 3

Structually the postsynaptic density can be devided into which two part?

Answer 3

Exterior and Interior

Question 4

What are the exterior part of PSD composed of？

Answer 4

(1) Neurotransmitter receptors (e.g. NMDAR, AMPAR)
(2) Adhesion molecules

Question 5

What are the interior part of PSD composed of？

Answer 5

(1) F-actin and actinbinding proteins
(2) Scaffold proteins
(3) Enzymes and enzymes binding proteins

Question 6

What type of proteinn is in the top layer of the scaffold protein in PSD?

Answer 6

DLG family

Question 7

What is the main functions of PSD family protein?

Answer 7

(1) To link the glutamate receptors between each other
(2) To signal the proteins and components of the cytoskeleton

Question 8

What is the main enzyme in PSD?

Answer 8

Calcium.calmodulin-dependent protein kinase Ⅱ

Question 9

The specific binding and fusion of membranes depends on what type proteins