1 Neurogenesis Flashcards
What will the neural tube develop into ?
CNS
What are the steps of neural development during embryogenesis
- Neurulation—-Neural tube formation (2-4 weeks)
2.Neural patterning
3.Proliferation
4.Migration
5.Differentiation
What are the steps of Neurogenesis?
1.Proliferation
2.Migration
3.Differention
Which gene is essential for the formation of both the midbrain and the hindbrain?
Otx2
Otx2 is essential gene for the formation of what parts of the brain?
midbrain and hindbrain
Which gene is essential for the formation of cerebellum?
Gbx2
Gbx2 is essential for the formation of which part of the brain?
cerebellum
What are the primary brain vesicles?
Forebrain, midbrain and hindbrain
What brain region does forebrain gives rise to?
- cerebrum, which includes the cerebral cortex, white matter and basal nuclei
- thalamus
3.hypothalamus
Which
What are the types of neural progenitors in ventricular and sub-ventricular zones? (in sequence)
early neuroepithelial cell, radial glial cells, intermediate progenitor
What type of cells will latter form layer one of the neocortex?
Cajal-Retzius cells
Which layer of the neocortex contains almost no neuronal cell bodies?
L1
Which layer of the neocortex contains neurons that project intra-cortically to the corpus callous?
L2/L3, aka the super granular layers
Which layer of the neocortex contains pyramidal and spiny stellate neurons?
L4, aka the granule layer
Which layer contains large projection neurons that give rise to vast majority of cortical efferent projections to basal ganglia, brain stem and spinal cord?
L5
Which layer of the neocortex is the main recipient layer of thalamocortical axons that relay sensory information?
L4, aka the granule layer
Which layer contains projection neurons that contribute significantly to the corticothalamic tract?
L6
Which two layers are together called the sub granular layers of the neocortex?
L5 and L6
In adult human, neurogenesis happens in which two regions?
Hippocampus and striatum
