1 Neurogenesis

Question 1

What will the neural tube develop into ?

Answer 1

CNS

Question 2

What are the steps of neural development during embryogenesis

Answer 2

1. Neurulation—-Neural tube formation (2-4 weeks)
   2.Neural patterning
   3.Proliferation
   4.Migration
   5.Differentiation

Question 3

What are the steps of Neurogenesis?

Answer 3

1.Proliferation
2.Migration
3.Differention

Question 4

Which gene is essential for the formation of both the midbrain and the hindbrain?

Answer 4

Otx2

Question 5

Otx2 is essential gene for the formation of what parts of the brain?

Answer 5

midbrain and hindbrain

Question 6

Which gene is essential for the formation of cerebellum?

Answer 6

Gbx2

Question 7

Gbx2 is essential for the formation of which part of the brain?

Answer 7

cerebellum

Question 8

What are the primary brain vesicles?

Answer 8

Forebrain, midbrain and hindbrain

Question 9

What brain region does forebrain gives rise to?

Answer 9

1. cerebrum, which includes the cerebral cortex, white matter and basal nuclei
2. thalamus
   3.hypothalamus

Question 10

Which

Question 11

What are the types of neural progenitors in ventricular and sub-ventricular zones? (in sequence)

Answer 11

early neuroepithelial cell, radial glial cells, intermediate progenitor

Question 12

What type of cells will latter form layer one of the neocortex?

Answer 12

Cajal-Retzius cells

Question 13

Which layer of the neocortex contains almost no neuronal cell bodies?

Answer 13

L1

Question 14

Which layer of the neocortex contains neurons that project intra-cortically to the corpus callous?

Answer 14

L2/L3, aka the super granular layers

Question 15

Which layer of the neocortex contains pyramidal and spiny stellate neurons?

Answer 15

L4, aka the granule layer

Question 16

Which layer contains large projection neurons that give rise to vast majority of cortical efferent projections to basal ganglia, brain stem and spinal cord?

Answer 16

L5

Question 17

Which layer of the neocortex is the main recipient layer of thalamocortical axons that relay sensory information?

Answer 17

L4, aka the granule layer

Question 18

Which layer contains projection neurons that contribute significantly to the corticothalamic tract?

Answer 18

L6

Question 19

Which two layers are together called the sub granular layers of the neocortex?

Answer 19

L5 and L6

Question 20

In adult human, neurogenesis happens in which two regions?

Answer 20

Hippocampus and striatum