2 Neuronal migration Flashcards
Is spiny projection neurons, aka pyramidal neuron, excitatory or inhibitory?
Excitatory
Is non-spiny GABAergic neuron excitatory or inhibitory?
Inhibitory
The inhibitory interneuron undergoes tangential migration or radial migration?
tangential migration
The excitatory neuron undergoes tangential migration or radial migration?
radial migration
What is the major signaling pathway in the migration behavior of cortical excitatory neurons?
Reelin signaling pathway
Reelin signaling pathway is about the migration behavior of which type of neurons?
cortical excitatory neurons
What is the biochemical essence of Reelin
large extracellular glycoprotein
Reelin is secreted by what type of cell? Where is that type of cell located?
Cajal-Retzius cells, which is located in marginal zone
Reelin affect which 2 aspect of radial neuronal migration?
(1) The ability of migrating neurons to split the prelate
(2) The ability of radial glial-guided neurons to migrate past older neurons to generate inside-out pattern of cortical layering
What are the three stage of neuronal migration in terms of molecular mechanism?
(1) Leading edge extension
(2) Nucleokinesis (Nuclear translocation)
(3) Retraction of the trialing process
Leading edge extension is regulated by whose polymerization?
Regulated by actin polymerization
Leading edge extension is regulated by which family of small GTPases?
The Tho family of small GTPases
RhoA inhibits or activates the leading edge extension?
inhibits
Cdc42 and Rac1 inhibit or activate the leading edge extension?
activate
The swelling in the nucleokinesis stage contains which two cell structures?
Centrosome and Golgi apparatus
