(8.2) CIS Biotransformation, Pharmacogenomics and Clinical Trials (Kruse) Flashcards
1
Q
A
A. Complete Phase I metabolism will yield more polar products
*Phase I reactions consist of enzymes that convert the parent drug to a more polar metabolite
2
Q
A
A. Glucuronidation
3
Q
A
D. The clearance is increased compared to a non-smoker (Half-life decreased)
Cigarrete smoke is a compound known for inducing P450 enzymes
4
Q
A
C. Enzyme induction
5
Q
A
E. Vitamin K epoxide reductase (VCORC1)
Pharmacodynamic : Drug target
Pharmacokinetic : WOULD BE cytochrome p450 34A
6
Q
A
B. Cytochrome P450 2C9
7
Q
A
C. Glucose 6-phosphate dehydrogenase
8
Q
A
D. NADPH
9
Q
A
D. Sulfamethoxazole
10
Q
A
D. Phase III
11
Q
A
C. Grapefruit juice
