(7.1) Adrenergic Drugs (Konorev) Flashcards
What are the primary targets of adrenergic drugs?
SYMPATHETIC systems
How do drugs that activate the adrenergic transmittion exert their effects?
Mimic or promote the effects of Norepinephring NE/epinephrine E/dopamine DA at adrenergic receptors in the sympathetic nervous system
How do drugs that inhibit the adrenergic transmittion exert their effects?
***What is the name of these drugs?
Prevent the effects of NE/E/DA at adrenergic receptor in the sympathetic nervous system
***Sympatholytics or Antiadrenergic drugs
What are the types of adrenergic receptors?
Alpha1
Alpha2
Beta
Dopamine
What G protein do alpha1 type act on?
What are the effects?
Gq
Increase IP3, DAG
What G protein do alpha2 type act on?
What are the effects?
Gi
Decrease cAMP
What G protein do ß type act on?
What are the effects?
Gs
Increase cAMP
What G protein do Dopamine types act on?
What are the effects?
D1 = Gs (Increase cAMP)
D2 = Gi (Decrease cAMP)
D3 = Gi (Decrease cAMP)
D4 = Gi (Decrease cAMP)
D5 = Gs (Increase cAMP)
Types of adrenergic agonist drugs
Direct adrenomimetics:
What are the alpha agonists?
Phenylephrine
Clonidine
Types of adrenergic agonist drugs
Direct adrenomimetics:
What are the mixed alpha and beta agonists?
Norepinephrine
Epinephrine
Types of adrenergic agonist drugs
Direct adrenomimetics:
What are the beta agonists?
Dobutamine
Isoproternol
Albuterol
Types of adrenergic agonist drugs
Direct adrenomimetics:
What are the dopamine agonists?
Dopamine
Alpha1 adrenergic receptors:
Tissue type?
Actions?
Most vascular smooth muscle ——— CONTRACTION
Pupillary dilator muscle —–CONTRACTION (dilates pupil)
Prostate —————— CONTRACTION
Heart ——————— Increases force of CONTRACTION
Alpha2 adrenergic receptors:
Tissue type?
Actions?
Postsynaptic CNS neurons —————- lots
Platelets ——————— Aggregation
Adrenergic and cholinergic nerve terminals ——– INHIBITS transmitter release
Some vascular smooth muscle ————– CONTRACTS
Fat cells —————— INHIBITS lipolysis
Beta1 adrenergic receptors:
Tissue type?
Actions?
Heart —————- Increases force and rate of contraction
Juxtaglomerular cells ———————— Increases renin release
C. Alpha2
