(6.2) Receptor Secondary Messenger and Location Flashcards

1
Q

α1A secondary messenger

A

Gq

increase IP3/DAG

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2
Q

α1B secondary messenger

A

Gq

increase IP3/DAG

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3
Q

α1D secondary messenger

A

Gq

increase IP3/DAG

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4
Q

α2 A secondary messenger

A

Gi

Decrease cAMP

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5
Q

α2B secondary messenger

A

Gi

Decrease cAMP

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6
Q

α2C secondary messenger

A

Gi

Decrease cAMP

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7
Q

β1 secondary messenger

A

Gs

Increase cAMP

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8
Q

β2 secondary messenger

A

Gs

Increase cAMP

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9
Q

β3 secondary messenger

A

Gs

Increase cAMP

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10
Q

D1 secondary messenger

A

Gs

Increase cAMP

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11
Q

D2 secondary messenger

A

Gi

Decrease cAMP

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12
Q

D3 secondary messenger

A

Gi

Decrease cAMP

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13
Q

D4 secondary messenger

A

Gi

Decrease cAMP

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14
Q

D5 secondary messenger

A

Gs

Increase cAMP

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15
Q

M1 secondary messenger

A

Gq

increase IP3/DAG

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16
Q

M2 secondary messenger

A

Gi

Decrease cAMP

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17
Q

M3 secondary messenger

A

Gq

increase IP3/DAG

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18
Q

M4 secondary messenger

A

Gi

Decrease cAMP

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19
Q

M5 secondary messenger

A

Gq

increase IP3/DAG

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20
Q

NM secondary messenger

A

α2β

Na/K channel for depolarization

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21
Q

NN secondary messenger

A

α/β only

Na/K channel for Depolarization

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22
Q

Easy way to remember M receptors

A

Odds are Gq

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23
Q

Easy way to remember D receptors

A

D1 and D5 are increase cAMP

all others decrease cAMP

24
Q

What Muscarinic receptor predominates the heart

A

M2

25
Q

What muscarinic receptor primarily found in smooth muscle

A

M3 and M2

26
Q

most common muscarinic receptor in most organs

A

M3

or otherwise about equal

27
Q

Adrenergic receptor for relaxation of ciliary muscle for far vision

A

β2

28
Q

adrenergic receptor for lacrimal secretions

A

α

29
Q

adrenergic receptor for radial muscle contraction in eye

A

α1

30
Q

adrenergic receptor to increase SA activity

A

β1>β2

31
Q

adrenergic receptor to increase contractility and conduction speed

A

β1>β2

32
Q

adrenergic receptor to increase AV activity

A

β1>β2

33
Q

adrenergic receptor to increase his-purkinje system activity

A

β1>β2

34
Q

adrenergic receptor to increase ventricular contractility and conduction velocity

A

β1>β2

35
Q

adrenergic receptor for vasoconstriction

A

α1

36
Q

adrenergic receptor for bronchodilation

A

β2

37
Q

adrenergic receptor for pregnant uterine contraction

A

α1

38
Q

adrenergic receptor for pregnant uterine relaxation

A

β2

39
Q

adrenergic receptor for nonpregnant uterine relaxation

A

β2

40
Q

adrenergic receptor for pilomotor contraction

A

α1

41
Q

adrenergic receptor for localized skin secretions

A

α1

42
Q

adrenergic receptor to increase salivary gland secretion

A

α1

43
Q

adrenergic receptor to increase skeletal muscle contractility

A

β2

44
Q

Eye muscarinic receptor

A

M3, M2

45
Q

Muscarinic Receptor to slow SA node

A

M2»M3

46
Q

Muscarinic Receptor to decrease contractility and conduction velocity in atria

A

M2»M3

47
Q

Muscarinic Receptor to decrease AV conduction velocity

A

M2»M3

48
Q

Muscarinic Receptor receptor to decrease activity of His-Purkinje system

A

M2»M3

not very effective

49
Q

Muscarinic Receptor in blood vessel and arteries to vasodilate

A

this isn’t a thing :)

50
Q

Muscarinic Receptor in endothelium to activate NO system

A

M3

51
Q

Muscarinic Receptor for tracheal/bronchial constriction

A

M2=M3

52
Q

Muscarinic Receptor to increase bronchial gland stimulation

A

M3, M2

53
Q

M1 are generally found

A

in nerves

54
Q

M2 are generally found

A

heart
nerves
smooth muscle

55
Q

M3 are generally found

A

glands
smooth muscle
endothelium

56
Q

M4 are generally found

A

CNS

57
Q

M5 are generally found

A

CNS