7th Physiology Lecture Exam - Endocrine (Batch 2025) COPY Flashcards
- Which of the following statements are true of adrenomedullary catecholamines?
A. They are secreted in the blood and acts as hormones
B. Majority of the circulating norepinephrine originates from the medullary cells
C. Majority of circulating norepinephrine are released from postganglionic neuron
D. The adrenal medulla is the sole source of catecholamine
A. They are secreted in the blood and acts as hormones
- Secretions of catecholamines from adrenal medulla are primarily regulated through?
A. Ascending sympathetic signals in response to stress
B. Initiation of the sympathetic response is by the cerebral cortex, limbic system, hypothalamus and brainstem
C. The hypothalamus and brainstem received input from cerebral cortex, limbic system and brainstem
D. The chromaffin cells received chemical signals via muscarinic receptors
C. The hypothalamus and brainstem received input from cerebral cortex, limbic system and brainstem
- Acetylcholine influences chromaffin cells activity by:
A. Secretions from post ganglionic sympathetic neurons and binding to chromaffin cells
B. Increasing the rate limiting enzyme in the chromaffin cell
C. Stimulating the formation of the chromaffin granules
B. Increasing the rate limiting enzyme in the chromaffin cell
- During the enzymatic process of epinephrine synthesis, this diffuses out of the chromaffin granules and is methylated by PNMT?
A. Dihydroxyphenylalanine
B. Dopamine
C. Norepinephrine
D. Epinephrine
C. Norepinephrine
- Epinephrine is more potent the norepinephrine for?
A. a1 receptors
B. a2 receptors
C. B1 receptors
D. B2 receptors
D. B2 receptors
- Adrenomedullary response can precede actual stress mainly due to the involvement of the:
A. Cerebral cortex
B. Hypothalamus
C. Limbic system
D. Brainstem
A. Cerebral cortex
- Which of the following stimuli evoke a stronger adrenomedullary response than a sympathetic nervous response?
A. Fear
B. Exercise
C. Pain
D. Hypovolemia
D. Hypovolemia
- What would be the effect of cortisol percolating through the chromaffin cells before draining into the suprarenal vein?
A. The formation of neurons and axons from medullary cells
B. Stimulation of medullary cells to undergo neuronal differentiation
C. Convert norepinephrine to epinephrine
D. Inhibit conversion of norepinephrine form dopamine
C. Convert norepinephrine to epinephrine
- Sympathoadrenal response during exercise include?
A. Inhibiting glucagon secretion and stimulating insulin secretion
B. Decreasing hepatic glycogenolysis and gluconeogenesis
C. Constriction of the bronchial smooth muscle
D. Decrease overall motility of GI and GU smooth muscles
D. Decrease overall motility of GI and GU smooth muscles
- Which of the following is increased when ACTH stimulates the zona fasciculata?
A. Low density lipoprotein particles binding to LDL receptors
B. Lysosomal lipase releases cholesterol from cholesterol esters
C. Hormone sensitive lipase (HSL) converts stored cholesterol into free cholesterol
D. Niemann-Pick C proteins transport free cholesterol from endolysosomes
C. Hormone sensitive lipase (HSL) converts stored cholesterol into free cholesterol
- 11B-HSO2 reversibly convert cortisol to cortisone in the cells that express:
A. Glucocorticoid receptor
B. Muscarinic receptor
C. Mineralocorticoid receptor
D. Nicotinic receptor
B. Muscarinic receptor
- Cortisol as a stress hormone, during the interdigestive period, regulates blood sugar by?
A. Stimulating glycolysis
B. Increasing glucose uptake in myocytes
C. Decreasing glucose uptake in adipocytes
D. Increasing protein synthesis
B. Increasing glucose uptake in myocytes
- Which of the following are inhibited by glucocorticoids?
A. Prostaglandins
B. Leukotrienes
C. Thromboxane
D. Phospholipase A2
D. Phospholipase A2
- Which one will increase the immune system with high cortisol levels?
A. T-Lymphocytes
B. Pro inflammatory cytokines
C. Anti inflammatory cytokines
D. Antibody production
C. Anti inflammatory cytokines
- What is the effect of cortisol in the GI tract?
A. Decrease GI motility
B. increase acid and enzyme production
C. Decrease appetite
D. Protect against ulcers
A. Decrease GI motility
- This is caused by excess ACTH acting on MC1R and often precedes all other symptoms of Addison’s disease?
A. Dehydration
B. Hypertension
C. Hyperpigmentation
D. Orthostasis
C. Hyperpigmentation
- Hypotension in Addison’s disease is due to?
A. Aldosterone
B. Volume depletion
C. Cortisol
D. Catecholamine
B. Volume depletion
- The effect of adrenocortical insufficiency in male includes:
A. Hirsutism
B. Amenorrhea
C. Hyperprolactinemia
D. Impotence
D. Impotence
- Which of the following criteria in interpreting rapid adrenocorticotropic hormone tests denotes abnormal adrenal function?
A. An increase in the baseline cortisol value of 7 mcg/dl or more
B. Cortisol value rises to 10 mcg/dl after 30-60mins
C. Aldosterone baseline value less than 5 ng/100ml
D. Aldosterone value that doubles after ACTH administration
D. Aldosterone value that doubles after ACTH administration
- Which one is the primary pharmacotherapy for Addison’s disease?
A. Glucocorticoids
B. Mineralocorticoids
C. Anti TB medications
D. Glucose supplementation
A. Glucocorticoids
- Subset of the endocrine system of intracellular enzymes or secreted enzymes that mostly inactivate precursors to highly active hormones?
A. Atrial natriuretic peptide
B. Erythropoietin
C. Angiotensin II
D. Insulin-like growth factor
C. Angiotensin II
- Control processes that leads to rupture of the follicle through the ovarian wall?
A. Positive feedback loop
B. Physiological response driven feedback loop
C. Endocrine axis-driven feedback loop
D. Negative feedback loop
A. Positive feedback loop
- Which hormone belong in the 2nd tier in the endocrine axis three tiered configuration?
A. Releasing hormones from the hypothalamus
B. Tropic hormones from the pituitary
C. Hormones from the peripheral gland
D. Ca++, Pi, Blood osmolarity
B. Tropic hormones from the pituitary
1: hypothalamus
2: pituitary gland
3: Organ
- Tertiary disease of the endocrine system are lesion in the?
A. Hypothalamus
B. Anterior Pituitary
C. Posterior Pituitary
D. Peripheral endocrine glands
A. Hypothalamus
1: Gland (Organ)
2: Pituitary
3: Hypothalamus
- Impose a daily rhythm to secretion of hypothalamic releasing hormones
A. Paracellular neurons
B. Magnocellular neurons
C. Suprachiasmatic neurons
D. Supraoptic nuclei
C. Suprachiasmatic neurons
- Damage to the pituitary stalk will have a decline in which pituitary tropic hormone?
A. ACTH
B. TSH
C. Vasopressin
D. FSH
C. Vasopressin
- Activity of a specific endocrine axis is maintained on a set point, which is?
A. The same for individuals
B. Determined by negative feedback
C. Function autonomously
D. Excludes hypothalamic function
B. Determined by negative feedback
- Which of the following has minimal influence on the set point of the endocrine function of the individual?
A. Exercise
B. Hypoglycemia
C. Growth
D. Puberty
C. Growth
- Endocrine deficiencies that are most severe?
A. Primary
B. Secondary
C. Tertiary
D. All of the above
A. Primary
- Requirement for hormonal action?
A. Hormone/receptor internalization
B. Proteasomal action on the receptor
C. Generation of feedback inhibitors
D. Inactivated intracellular messengers
A. Hormone/receptor internalization
- During the fasting state, blood glucose is maintained by?
A. Glucose utilization
B. Hepatic glucose production
C. FFA production
D. Muscle build up
B. Hepatic glucose production
- Dominant during the digestive phase of metabolism?
A. Glucagon
B. Epinephrine
C. Insulin
D. Cortisol
C. Insulin
- Absolutely dependent on glucose?
A. Hepatocytes
B. Erythrocytes
C. Enterocytes
D. Adipocytes
B. Erythrocytes
- Activation of Akt protein kinase will?
A. Translocate Glut2 in myocytes and adipocytes
B. Activate proteasomal degradation of protein
C. Inhibition of de novo lipogenesis
B. Activate proteasomal degradation of protein
- Action of hepatocytes during the fasting state?
A. Utilization of glucose for ATP
B. Store glucose as glycogen
C. Synthesis of glucose from precursors
D. Make FFA from glucose
C. Synthesis of glucose from precursors
- Glucose during the fasting phase with adipocytes?
A. Increase glucose uptake
B. ATP utilization of glucose
C. Utilization for G6P of glucose
D. Use of alternative fuels
D. Use of alternative fuels
- FFA with hepatocytes during fasting phase?
A. De novo lipogenesis
B. Uptake of chylomicron remnants
C. Esterify FFAs into intrahepatic TG
D. Utilization to produce KB
D. Utilization to produce KB
- Glucose during fasting phase in myocytes?
A. Use of alternative fuels
B. Utilization for ATP
C. Stored as glycogen
D. Increase uptake
A. Use of alternative fuels
- Primary effect of glucagon?
A. Enhance glycogenolysis in myocytes
B. Increase fatty acyl oxidation in myocytes
C. Increase hormone sensitive lipase in adipocytes
D. Increase glycogenolysis in hepatocytes
D. Increase glycogenolysis in hepatocytes
- Stimuli that inhibits insulin secretion?
A. Increase serum glucose
B. Activation of a2 adrenergic receptors
C. Increase levels of amino acids
D. Release of incretin hormones
B. Activation of a2 adrenergic receptors
Pre-synapse: CNS
Vasodilation(Dec. NE/EPI/Insulin)
Sedation
Depression
- This hormone recruits several large antral follicles to begin gonadotropin-dependent growth during the first few days of the female menstrual cycle:
A. Estrogen
B. FSH
C. LH
D. Progesterone
B. FSH
- Which of the following structures is the source of progesterone and estrogen during the secretory phase of the menstrual cycle?
A. Dominant follicle
B. Growing antral follicle
C. Primordial follicle
D. Corpus luteum
D. Corpus luteum (7)