7.7 Metabolic Integration Flashcards

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1
Q

what happens to excess glucose in cells?

A

it can be stored in cells and then mobilized when necessary

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2
Q

what are the two major forms for glucose storage?

A

glycogen and starch

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3
Q

glycogen

A

the form in which glucose is stored in animals

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4
Q

starch

A

the form in which glucose is stored in plants

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5
Q

describe the structure of glycogen:

A

a large, branched chain of glucose molecules attached to a central protein.

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6
Q

describe the structure of starch:

A

a large, branched chain of glucose molecules found in plants,stored in granules inside cells

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7
Q

where can glycogen be stored?

A

the muscle (provides ATP for muscle contraction) or he liver (central glycogen storehouse)

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8
Q

glycogen provides a source of:

A

glucose-6-phosphate (cleaved as glucose 1-phosphate and then converted into glucose 6-phosphate which is an intermediate in glycolysis)

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9
Q

how many ATP molecules are produced from one glucose molecule cleaved from a glycogen chain?

A

3 (ATP consuming step 1 is bypassed)

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10
Q

how are disaccharides hydrolyzed?

A

they are converted into monosaccharides, generally glucose which directly enters glycolysis

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11
Q

how are monosaccharides other than glucose hydrolyzed?

A

they are converted into intermediates of glycolysis that come later in the pathway

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12
Q

in addition to carbohydrates, what is a good source of energy?

A

lipids (C-H bonds carry lots of chemical potential energy)

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13
Q

B-(beta)oxidation

A

the process of shortening fatty acids by a series of reactions that sequentially remove two carbon units from their ends

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14
Q

beta oxidation does not produce ATP, instead it…

A

releases a large number of NADH and FADH2 that provide electrons for the synthesis of ATP by oxidative phosphorylation

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15
Q

fatty acids are a useful and efficient source of energy but cannot:

A

be used by all tissues of the body (ex. brain and red blood cells depend on glucose for energy)

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16
Q

ATP is constantly being “turned over” in cells, what does this mean?

A

ATP is constantly being broken down to ADP and P and synthesized to ATP

17
Q

the level of ATP inside a cell can indicate:

A

how much energy a cell has available

18
Q

high levels of ATP indicate:

A

the cell has large amounts of free energy and is poised to carry out cellular processes; pathways that generate ATP are slowed or down-regulated

19
Q

low levels of ATP indicate:

A

the cell activates or up-regulates pathways that lead to ATP synthesis

20
Q

high NAD+ levels stimulate:

A

cellular respiration

21
Q

high NADH levels:

A

inhibit cellular respiration

22
Q

what is one of the cell’s mechanisms to control key steps of the pathway?

A

the regulation of enzymes

23
Q

the 3rd reaction of glycolysis (fructose 6-phosphate converted to fructose 1,6-biphosphate -ATP is consumed) is:

A

highly endergonic and irreversible! IT IS CATALYZED BY PHOSPHOFRUCTOKINASE-1 (PFK-1)

24
Q

PRK 1 can be thought of as a :

A

metabolic valve that regulates the rate of glycolysis-the 3rd step is viewed as a “committed” step to glycolysis and is subject to tight control

25
Q

PRK-1 is an allosteric enzyme with:

A

many activators and inhibitors-changes its shape and activity in response to the binding of molecules at a site other than the active site

26
Q

what are allosteric activators of PFK-1?

A

ADP and AMP-activates the enzyme and increases the rate of glycolysis and the synthesis of ATP

27
Q

when ATP or citrate is in abundance, it can bind to the enzyme (PFK-1) and:

A

inhibits the enzyme’s catalytic activity, glycolysis and the rate of ATP production slows down

28
Q

cellular respiration is inhibited by:

A

its products (ATP and NADH)

29
Q

cellular respiration is activated by:

A

its substrates (ADP and NAD+)