77. Granulopoiesis

Question 1

what is granulopoiesis

Answer 1

developoing basophils, eoisinpills, neutrophils (all temed granuosytes as they appear as granules)

Question 2

what does it inovlve

Answer 2

involves cytoplasmic changes dominated by synthesis of proteins for the azurophilic granules and
specific granules. These proteins made in ER

Question 3

what are the stages

Answer 3

1. pluripotent hemopoietic stem cell
2. myeloblast - first recognizable cell has finely dispersed chromatin, and faint nucleoli
3. promyelocyte - has basophilic cytoplasm and azurophilic granules
4. myelocyte (eoisno, neut, baso) - doesn’t hv nucleolus + specific granules produced. eosinophilic myelocytes= red gran, basophilic = coarse blue gran, neutrophilic = fine salmon gran
5. metamylocytes - doesnt divide and make granules
6. Band cell - cytoplasm filled with granules
7. mature granulocyte

Question 4

what are GCSFs and how long does the process take

Answer 4

proteins that signal cells i bone marrow to begin process of becoming granulocytes.
10-14 days