73 & 74 Pharm: Seizure Tx Flashcards
Seizure Drugs: Sodium Channel Modulators
- What are the 5 drugs for this class?
- What state do they inhibit?

Seizure Drugs: Sodium Channel Modulators
- Label each of these clincal uses with one of the drugs
- Carbamazepine
- Lacosamide
- Phenytoin, Fosphenytoin
- Lamotrigine

Seizure Drugs: Sodium Channel Modulators
- Which drug is the first line treatment for trigeminal neuralgia?
Carbamazepine
Seizure Drugs: Sodium Channel Modulators
- Give the ADRs for each of these
- Carbamazepine (3)
- Lacosamide (4)
- Phenytoin, Fosphenytoin (5)
- Lamotrigine (1)
- Carbamazepine
- Lacosamide
- Phenytoin, Fosphenytoin
- Lamotrigine

Seizure Drugs: Sodium Channel Modulators
- What DDI does carbamazepine have?
- What DDI does Phenytoin/fosphenytoin have?
- What DDI does Lamotrigine have?
- Carbamazepine
- Lacosamide
- Phenytoin, Fosphenytoin
- Lamotrigine

Seizure Drugs: Sodium Channel Modulators
- What are the contraindications for:
- Lacosamide
- Phenytoin, Fosphenytoin
- Lacosamide
- Phenytoin, Fosphenytoin
Seizure Drugs: Ca 2+ Channel Modulators
- What are the 3 drugs for this class?
- How do they differ in terms of channels that they act on?

Seizure Drugs: Ca 2+ Channel Modulators
- What is the clinical use of gabapentin/pregabalin?
- What is the clinical use of ethosuximide?
Seizure Drugs: Ca 2+ Channel Modulators
- gabapentin/pregabalin
- ethosuximide
Seizure Drugs: Ca 2+ Channel Modulators
- What other clinical use does gabapentin/pregabalin have?
anxiety disorders and neuropathic pain
Seizure Drugs: Ca 2+ Channel Modulators
- What are the ADRs for gabapentin/pregabalin? (2)
- What are the ADRs for ethosuximide? (7)
Seizure Drugs: Ca 2+ Channel Modulators
- gabapentin/pregabalin
- ethosuximide

Seizure Drugs: Ca 2+ Channel Modulators
- DDIs
- What happens when gabapentin/pregabalin are used at high doses?
- What enzyme metabolizes ethosuximide, and what is notable about its half-life?
Seizure Drugs: Ca 2+ Channel Modulators
- gabapentin/pregabalin
- ethosuximide

Seizure Drugs: Ca 2+ Channel Modulators
- What contraindications exits for gabapentin/pregabalin?

Seizure Drugs: Glutamatergic Signaling Modulators
- What are the 3 drugs for this class?
- What is the individual MOA for each of these?

Seizure Drugs: Glutamatergic Signaling Modulators
- What is the clinical use for:
- Perampanel (3)
- Felbamate (2)
- Levetiracetam (3)
Seizure Drugs: Glutamatergic Signaling Modulators
- Perampanel
- Felbamate
- Levetiracetam

Seizure Drugs: Glutamatergic Signaling Modulators
- What are the notable ADRs for this drug?
- Perampanel (1)
- Felbamate (2)
- Levetiracetam (1)
- What is a notable DDI for this drug?
Seizure Drugs: Glutamatergic Signaling Modulators
- Perampanel
- Felbamate
- Levetiracetam
- Behavior and mood drugs

Seizure Drugs: Enhancing Inhibitory Signal
- What 2 drugs fall under this class?
- What is the MOA for each one both?

Seizure Drugs: Enhancing Inhibitory Signal
- What are clinical uses for
- Vigabatrin (1)
- Tiagabine (1)
Seizure Drugs: Enhancing Inhibitory Signal
- Vigabatrin
- Tiagabine

Seizure Drugs: Enhancing Inhibitory Signal
- What are the notable ADRs for:
- Vigabatrin (1)
- What is contraindicated for this drug?
- Tiagabine (8)
- Vigabatrin (1)
Seizure Drugs: Enhancing Inhibitory Signal
- Vigabatrin
- Preexisting mental illness
- Tiagabine

Seizure Drugs: Barbituates
- What drug is used?
- What does it do to GABAa?
- What is the clinical use for it?

Seizure Drugs: Barbituates
- Phenobarbital
- What ADRs exist for this drug? (6)
- What DDI does it have?
- What are the contraindications for it? (2)

Seizure Drugs: Benzodiazepines
- What 5 drugs exist for this class?
- What do they do to GABAa?

Seizure Drugs: Benzodiazepines
- Give the clinical uses for
- Diazepam (IV), Lorazepam (IV), Midazolam (IM)
- Clonazepam
- Clobazam
- Other USE: What syndrome is this used to treat?
Seizure Drugs: Benzodiazepines
- Diazepam (IV), Lorazepam (IV), Midazolam (IM)
- Clonazepam
- Clobazam

Seizure Drugs: Benzodiazepines
- Diazepam (IV) and Lorazepam (IV)
- Which drug is preferred and why?
- Clonazepam
- What DDI does this drug have?
- Diazepam (IV) and Lorazepam (IV)
- Clonazepam

Seizure Drugs: Drugs w. multiple MOAs
- Give the MOAs for the following drugs
- Topiramate (4)
- Valproate (4)
Seizure Drugs: Drugs w. multiple MOAs
- Topiramate
- Valproate

Seizure Drugs: Drugs w. multiple MOAs
- Topiramate and Valproate
- What are the clinical uses of these drugs?
- Topiramate
- Valproate

Seizure Drugs: Drugs w. multiple MOAs
- Topiramate
- What ADRs exist for this drug? (5)
- Valproate
- What ADRs exist for this drug? (5)
- What enzyme is inhibited by this drug?
Seizure Drugs: Drugs w. multiple MOAs
- Topiramate
- Valproate
