73 & 74 Pharm: Seizure Tx

Question 1

Seizure Drugs: Sodium Channel Modulators

• What are the 5 drugs for this class?
• What state do they inhibit?

Answer 1

Question 2

Seizure Drugs: Sodium Channel Modulators

• Label each of these clincal uses with one of the drugs

Answer 2

1. Carbamazepine
2. Lacosamide
3. Phenytoin, Fosphenytoin
4. Lamotrigine

Question 3

Seizure Drugs: Sodium Channel Modulators

• Which drug is the first line treatment for trigeminal neuralgia?

Answer 3

Carbamazepine

Question 4

Seizure Drugs: Sodium Channel Modulators

• Give the ADRs for each of these
  
  • Carbamazepine (3)
  • Lacosamide (4)
  • Phenytoin, Fosphenytoin (5)
  • Lamotrigine (1)

Answer 4

1. Carbamazepine
2. Lacosamide
3. Phenytoin, Fosphenytoin
4. Lamotrigine

Question 5

Seizure Drugs: Sodium Channel Modulators

• What DDI does carbamazepine have?
• What DDI does Phenytoin/fosphenytoin have?
• What DDI does Lamotrigine have?

Answer 5

1. Carbamazepine
2. Lacosamide
3. Phenytoin, Fosphenytoin
4. Lamotrigine

Question 6

Seizure Drugs: Sodium Channel Modulators

• What are the contraindications for:
  
  • Lacosamide
  • Phenytoin, Fosphenytoin

Answer 6

1. Lacosamide
2. Phenytoin, Fosphenytoin

Question 7

Seizure Drugs: Ca 2+ Channel Modulators

• What are the 3 drugs for this class?
• How do they differ in terms of channels that they act on?

Answer 7

Question 8

Seizure Drugs: Ca 2+ Channel Modulators

1. What is the clinical use of gabapentin/pregabalin?
2. What is the clinical use of ethosuximide?

Answer 8

Seizure Drugs: Ca 2+ Channel Modulators

1. gabapentin/pregabalin
2. ethosuximide

Question 9

Seizure Drugs: Ca 2+ Channel Modulators

• What other clinical use does gabapentin/pregabalin have?

Answer 9

anxiety disorders and neuropathic pain

Question 10

Seizure Drugs: Ca 2+ Channel Modulators

1. What are the ADRs for gabapentin/pregabalin? (2)
2. What are the ADRs for ethosuximide? (7)

Answer 10

Seizure Drugs: Ca 2+ Channel Modulators

1. gabapentin/pregabalin
2. ethosuximide

Question 11

Seizure Drugs: Ca 2+ Channel Modulators

• DDIs
  
  • What happens when gabapentin/pregabalin are used at high doses?
  • What enzyme metabolizes ethosuximide, and what is notable about its half-life?

Answer 11

Seizure Drugs: Ca 2+ Channel Modulators

1. gabapentin/pregabalin
2. ethosuximide

Question 12

Seizure Drugs: Ca 2+ Channel Modulators

• What contraindications exits for gabapentin/pregabalin?

Answer 12

Question 13

Seizure Drugs: Glutamatergic Signaling Modulators

• What are the 3 drugs for this class?
  
  • What is the individual MOA for each of these?

Answer 13

Question 14

Seizure Drugs: Glutamatergic Signaling Modulators

• What is the clinical use for:
  
  • Perampanel (3)
  • Felbamate (2)
  • Levetiracetam (3)

Answer 14

Seizure Drugs: Glutamatergic Signaling Modulators

1. Perampanel
2. Felbamate
3. Levetiracetam

Question 15

Seizure Drugs: Glutamatergic Signaling Modulators

• What are the notable ADRs for this drug?
  
  • Perampanel (1)
  • Felbamate (2)
  • Levetiracetam (1)
    
    • What is a notable DDI for this drug?

Answer 15

Seizure Drugs: Glutamatergic Signaling Modulators

1. Perampanel
2. Felbamate
3. Levetiracetam
   
   • Behavior and mood drugs

Question 16

Seizure Drugs: Enhancing Inhibitory Signal

• What 2 drugs fall under this class?
  
  • What is the MOA for each one both?

Answer 16

Question 17

Seizure Drugs: Enhancing Inhibitory Signal

• What are clinical uses for
  
  • Vigabatrin (1)
  • Tiagabine (1)

Answer 17

Seizure Drugs: Enhancing Inhibitory Signal

1. Vigabatrin
2. Tiagabine

Question 18

Seizure Drugs: Enhancing Inhibitory Signal

• What are the notable ADRs for:
  
  • Vigabatrin (1)
    
    • What is contraindicated for this drug?
  • Tiagabine (8)

Answer 18

Seizure Drugs: Enhancing Inhibitory Signal

1. Vigabatrin
   
   • Preexisting mental illness
2. Tiagabine

Question 19

Seizure Drugs: Barbituates

• What drug is used?
• What does it do to GABAa?
• What is the clinical use for it?

Answer 19

Question 20

Seizure Drugs: Barbituates

• Phenobarbital
  
  • What ADRs exist for this drug? (6)
  • What DDI does it have?
  • What are the contraindications for it? (2)

Answer 20

Question 21

Seizure Drugs: Benzodiazepines

• What 5 drugs exist for this class?
• What do they do to GABAa?

Answer 21

Question 22

Seizure Drugs: Benzodiazepines

• Give the clinical uses for
  
  • Diazepam (IV), Lorazepam (IV), Midazolam (IM)
  • Clonazepam
  • Clobazam
    
    • Other USE: What syndrome is this used to treat?

Answer 22

Seizure Drugs: Benzodiazepines

1. Diazepam (IV), Lorazepam (IV), Midazolam (IM)
2. Clonazepam
3. Clobazam

Question 23

Seizure Drugs: Benzodiazepines

• Diazepam (IV) and Lorazepam (IV)
  
  • Which drug is preferred and why?
• Clonazepam
  
  • What DDI does this drug have?

Answer 23

1. Diazepam (IV) and Lorazepam (IV)
2. Clonazepam

Question 24

Seizure Drugs: Drugs w. multiple MOAs

• Give the MOAs for the following drugs
  
  • Topiramate (4)
  • Valproate (4)

Answer 24

Seizure Drugs: Drugs w. multiple MOAs

1. Topiramate
2. Valproate

Question 25

Seizure Drugs: Drugs w. multiple MOAs

• Topiramate and Valproate
  
  • What are the clinical uses of these drugs?

Answer 25

1. Topiramate
2. Valproate

Question 26

Seizure Drugs: Drugs w. multiple MOAs

• Topiramate
  
  • What ADRs exist for this drug? (5)
• Valproate
  
  • What ADRs exist for this drug? (5)
  • What enzyme is inhibited by this drug?

Answer 26

Seizure Drugs: Drugs w. multiple MOAs

1. Topiramate
2. Valproate