51 Pharmacology: Cholinolytics

Question 1

Muscarinic Receptors

• Which receptors are associated with Gq?
• Which receptors are associated with Gi?

Answer 1

Question 2

Muscarinic Receptors

• Are these associated with M1, M3, M5 or M2, M4 receptors?

Answer 2

M1, M3, M5

Question 3

Muscarinic Receptors

• Are these associated with M1, M3, M5 or M2, M4 receptors?

Answer 3

M2, M4

Question 4

Clinical Applications for Muscarinic Antagonists

• What are the 9 clinical applications for these parasympathetic blockers?

Answer 4

Question 5

Muscarinic Antagonists

• For belladonna alkaloids, what is the prototype drug?

Question 6

Atropine

• What kind of amine is it?
• What receptor does it bind to?
• What does it inhibit?
• Describe the effects of the doses that are listed
• What can it be an antidote for?
  
  • What other drug is needed for one of the antidotes?
• How long do its ophthalmologic effects last?

Answer 6

Atropine

• What kind of amine is it?
  
  • Tertiary
• What receptor does it bind to?
  
  • Muscarinic (Good for M2)
• What does it inhibit?
  
  • Acetylcholine binding to Muscarinic receptors
• Describe the effects of the doses that are listed
• What can it be an antidote for?
  
  • Mushrooms
  • Organophosphate poisoning
    
    • Need Pralidoxime (2-PAM) too!!!
• How long do its ophthalmologic effects last?
  
  • 7 to 10 days

Question 7

Scopolamine

• What kind of amine is it?
• What is it used for?
• How long does it have ophthalmologic effects?
• What are some ADRS?

Answer 7

Scopolamine

• What kind of amine is it?
  
  • Tertiary
• What is it used for?
  
  • Motion Sickness
  • End of Life Care
    
    • Will decrease oral secretions and adds sedation
• How long does it have ophthalmologic effects?
  
  • 3 to 7 days
• What are some ADRS?
  
  • Sedation
  • Dry Mouth
  • Blurry Vision

Question 8

Benztropine And Trihexyphenidyl

• What are these drugs used for?
  
  • What other drug is used with them?
• What are the ADRS?

Answer 8

Question 9

Tropicamide

• What is this drug used for?
• What are the side effects? (There is a big one)
• How long does its Ophthalmologic effects last?

Answer 9

Question 10

Dicyclomine

• What is this drug used for?
  
  • why?

Answer 10

Question 11

Ipratropium and Tiotropium

• What kind of amines are these?
• What are they used for?
  
  • Why?

Answer 11

Question 12

Urinary Incontinence and Overactive Bladder Syndrome

• What are the nonselective muscarinic antagonists for this?
  
  • Which one does not act on M2?
• What are the M3 selective antagonists?

Answer 12

Question 13

Pralidoxime (2-PAM)

• What is this used for?

Answer 13