43 Pharmacology: Tx of Headaches Flashcards
1
Q
Pathophysiology of Migraines
- What structures are implicated in these?
- What 3 neuropeptides are involved with these?
- What type of signal transmission and sensitization occurs?
A
2
Q
Migraine
- How do these HA’s present?
- How does hunger relate to this?
- What is involved with migraine aura? (5)
- What can alleviate pain?
- How is sleep involved?
- What does the acronym POUND mean?
A
3
Q
Migraine
- What are the 3 specific Rx treatments for this?
- What are the 5 nonspecific Rx treatments for this?
A
4
Q
Triptans
- What do all these drugs end with?
- What receptor do they act on?
- Are they agonist or antagonists?
- What kind of headaches are they they the first line choice for?
- How fast do they work?
- How effective are they
- ADRs
- What are the 5 main ADRs for this?
- What conditions are contraindicated for triptan use?
A
5
Q
Ergots
- What are the three types of ergots?
- What receptor do they act on?
- Are they agonists or antagonists?
- What happens to vessels?
- Do these have abuse risk?
- What condition can these cause that you have to watch out for?
- What conditions are contraindicated (5)?
A
6
Q
CGRP Antibodies
- Are these agonists or antagonists?
- What 3 drugs fall under this category?
A
7
Q
Opioids and Butalbital
- Opioids
- What receptor do these act on?
- Is it an agonist or antagonist?
- When are they indicated in headaches?
- What receptor do these act on?
- Butalbital Combination Analgesics
- What kind of drug is Butalbital?
- What receptor does it act on?
- Is it an agonist or antagonist?
- How does this cause CNS depression?
- What are the major concern for these?
A
8
Q
Botulinum Toxin (BOTOX)
- What happens to acetylcholine?
- What pathway is decreased?
- What neuropeptides have decreased production?
- What happens to serotonin?
- What 2 ADRs can occur?
A
9
Q
Corticosteroids
- What is the corticosteroid of choice?
- What is this an analog of?
- Glucocorticoid
- Is this anti-inflammatory or does it cause fluid retention/hypokalemia?
- Mineralocorticoid
- Is this anti-inflammatory or does it cause fluid retention/hypokalemia?
- What ADRs does dexamethasone have? (3)
A
10
Q
Beta Blockers
- What 3 beta blockers are used?
- What are they used for?
- How do these modulate vascular tone?
- What ADR is associated with this?
- What conditions are contraindicated? (3)
A
11
Q
Antidepressants
- Tricyclic Antidepressants
- What drug is used?
- What is its MOA (3)
- What ADRs are associated with it?
- What condition is contraindicated?
- SSRI
- What SSR’s are used?
- Why do these suck fo rheadaches?
A
12
Q
Anticonvulsants
- What contraindication exists for all of these?
- Valproate
- What is the MOA for this?
- What ADRs exist?
- What is contraindicated?
- Topiramate
- What is the MOA for this?
- What ADRs exist?
- What is contraindicated?
- Gabapentin
- What is the MOA for this?
- What ADRs exist?
- What is contraindicated?
A
13
Q
Tension Headache
- What are the 3 main triggers for this?
- Where does it manifest?
- What is it notably not associated with?
A
14
Q
Tension Headache
- Treatments
- What drugs are used in monotherapy?
- What drugs are used in combination therapy?
- What drugs are used in prophylaxis?
A
15
Q
Cluster Headaches
- How long do attacks last?
- When do they often occur?
- Where on the head do they often occur?
- Where does pain manifest?
- What kind of activity do patients have?
A
16
Q
Cluster Headaches
- Abortive Therapy
- What are the 3 methods for this?
- For the loan non-Rx treatment, how long should it last?
- What are the 3 methods for this?
A
17
Q
Cluster Headaches
- Prophylactic Therapy
- What is the first line treatment?
- How long does this take work?
- What other drug can be used as an alternative to this or in combination?
- What are the side effects of this drug?
- What do you need to monitor and what kind of patients need to be treated with caution?
- What kind of drug is used for inducing remission?
- What is the first line treatment?
A
