67 Pharmacology: Alzheimer and Parkinson Drugs Flashcards
1
Q
Parkinson Drugs
- What are the dopamine precursors?
A
![](https://s3.amazonaws.com/brainscape-prod/system/cm/275/138/751/a_image_thumb.png?1555430770)
2
Q
Parkinson Drugs
- What are the dopamine receptor agonists?
A
![](https://s3.amazonaws.com/brainscape-prod/system/cm/275/138/753/a_image_thumb.png?1555430993)
3
Q
Parkinson Drugs
- What are the inhibitors of dopamine metabolism?
A
![](https://s3.amazonaws.com/brainscape-prod/system/cm/275/138/755/a_image_thumb.png?1555431075)
4
Q
Parkinson Drugs
- What are the anticholinergics used for Parkinson Disease?
A
![](https://s3.amazonaws.com/brainscape-prod/system/cm/275/138/757/a_image_thumb.png?1555431120)
5
Q
Parkinson Drugs
- What is the antiviral used for Parkinson Disease?
A
![](https://s3.amazonaws.com/brainscape-prod/system/cm/275/138/760/a_image_thumb.png?1555431153)
6
Q
Parkinson Drugs
- What is the precursor to L-DOPA?
- What converts L-DOPA to dopamine?
A
![](https://s3.amazonaws.com/brainscape-prod/system/cm/275/138/762/a_image_thumb.png?1555431401)
7
Q
Parkinson Drugs
- Levodopa
- Where is most of the oral dose absorbed?
- Where is most of the oral dose metabolized?
- What percent actually reaches circulation?
- How much of an absorbed dose actually is converted to dopamine in the CNS?
- How much is converted to dopamine in the periphery?
A
![](https://s3.amazonaws.com/brainscape-prod/system/cm/275/138/764/a_image_thumb.png?1555431684)
8
Q
Parkinson Drugs
- Levodopa + Carbidopa
- What is carbidopa?
- Where does it act?
- How is the dose calculated?
- How does Levodopa + Carbidopa increase circulation concentrations compared to Levodopa without Carbidopa?
- What about CNS absorption?
- What is carbidopa?
A
![](https://s3.amazonaws.com/brainscape-prod/system/cm/275/138/765/a_image_thumb.png?1555432282)
9
Q
Parkinson Drugs
- Levodopa + Carbidopa
- What symptom is most relieved about this?
- What is NOT prevented with this?
- When are the benefits of therapy greatest?
- When do benefits diminish?
- What are the 3 reasons for this?
- When do benefits diminish?
A
![](https://s3.amazonaws.com/brainscape-prod/system/cm/275/138/767/a_image_thumb.png?1555432400)
10
Q
Parkinson Drugs
- Levodopa + Carbidopa
-
ADRS
- What set of ADRs decreases when Levodopa is used with Carbidopa?
- What set of ADRs increases when Levodopa is used with Carbidopa?
- What ADR is related to an increase of catecholamines in the periphery?
-
Contraindications
- What mental illness is contraindicated?
- What abdominal condition is contraindicated?
- What kind of patient history is contraindicated?
-
ADRS
A
![](https://s3.amazonaws.com/brainscape-prod/system/cm/275/138/769/a_image_thumb.png?1555432551)
11
Q
Parkinson Drugs
- Dopamine Receptor Agonists
- What is the MOA for these drugs?
- Compared to Levodopa + Carbidopa, these have 3 benefits. What are they?
- ADRS
- What 6 sets of ADRs exist with these drugs?
![](https://s3.amazonaws.com/brainscape-prod/system/cm/275/138/772/q_image_thumb.png?1555432800)
A
![](https://s3.amazonaws.com/brainscape-prod/system/cm/275/138/772/a_image_thumb.png?1555433041)
12
Q
Parkinson Drugs
- MAO I Inhibitors
- What drugs fall under this category?
- What do these drugs inhibit the conversion of?
- Which MAO I Inhibitor is used as a monotherapy?
- When?
- How do these drugs relate to levodopa/carbidopa?
- What levodopa/carbidopa ADR is REDUCED when using MAO I Inhibitors?
- Which levodopa/carbidopa ADR is INCREASED when using MAO I Inhibitors?
- Other ADRS
- Which MAO I Inhibitors has a similar ADR to Adderall?
- Why?
- What does inhibiting MAO in the GI tract do?
- What syndrome can occur with MAO I Inhibitor use?
- Which MAO I Inhibitors has a similar ADR to Adderall?
A
![](https://s3.amazonaws.com/brainscape-prod/system/cm/275/138/774/a_image_thumb.png?1555433702)
13
Q
Parkinson Drugs
- COMT Inhibitors
- What 2 drugs fall under this category?
- Which drug exclusively works in the periphery, and which one works in both the CNS and periphery?
- What reaction do these drugs inhibit?
- How do these drugs relate to levodopa/carbidopa?
- What ADR is reduced?
- Which ADRs are increased?
- Other ADRS
- What ADR is related to urine, and which COMT inhibitor does this?
- What black box label warning exists, and which COMT inhibitor is this for?
- What is stavelo?
- What 2 drugs fall under this category?
A
![](https://s3.amazonaws.com/brainscape-prod/system/cm/275/138/776/a_image_thumb.png?1555434191)
14
Q
Parkinson Drugs: Anticholinergics
- What are the 4 cholinergics?
- Where in the basal ganglia are MANY subtypes of M receptors found?
- What is the rational for using these in Parkinsons?
- Do these affect tremor?
- Do these affect bradykinesia?
- What are the ADRs for these?
A
![](https://s3.amazonaws.com/brainscape-prod/system/cm/275/138/779/a_image_thumb.png?1555801240)
15
Q
Parkinson Drugs: Amantadine
- What kind of drug is this, and what do it normal treat?
- Altohugh the MOA is unknown, what are the 4 general things it does that can be neuroprotective?
- Parkinsons
- What does it benefit in Parkinsons?
- How long does this act?
- What does it benefit in Parkinsons?
- ADRS
- What are the three sets of ADRs for this drug?
A
![](https://s3.amazonaws.com/brainscape-prod/system/cm/275/138/824/a_image_thumb.png?1555801526)