7. Vasodilators Flashcards
wc vasodilator has venodilation»_space; artiodilation?
Nitroglycerin
2 uses for PDE5 inhibitors?
suffix?
erectile dysfunciton
BPH
-afil
4 AEs of ACE inhibitors?
tetratogenic
cough
hyperkalemia
hypersensitivity
acute AE of nitroprusside?
chronic? symptoms
Hypotension
thiocyanate toxicity
- weakness, nausea, convulsions
3 uses for Ca blockers?
Angina
Supraventricular tachyarrhythmias (verapamil)
HTN
MOA of Aliskiren?
inhibits Renin
3 guanylyl cyclase activators?
MOA?
Nitroprusside
Organic Nitrates
Hydralazine
inc cGMP –> vasodilation
hw to treat respiratory failure in neonates with pulmonary hypertension?
Nitric oxide
4 uses for ACE inhibitors?
hypertension
CHF
post MI
diabetic nephropathy
3 effects of ACE inhibitors?
suffix?
dec TPR
dec Na and fluid retention
dec BP
-pril
MOA of K channel openers?
increase K efflux at SM –> hyperpolarization –> relaxation –> dec TPR
MOA of nitroprusside?
net effect?
arteriodilation = venodilation
dec. TPR, dec CO, dec BP, inc HR
how are verapamil and diltiazem different from DHPs?
AEs?
V and D dec AV nodal conduction
Heart block
MOA of Ca channel blockers?
effect?
phases affected?
inhibit L-type Ca channels
arteriodilation –> dec. TPR –> dec. BP
inhibit phase 0 depolarization in SA and AV nodes.
inhibit phase 2 of AP in muscle
Name a K channel opener?
use?
Minoxidil
malignant HTN
3 uses for nitroglycerin?
angina
CHF
Acute MI
MOA of phosphodiesterase inhibitors?
name some
inhibit PDE type 5 –> potentiates NO –> inc cGMP
MOA of hydralazine?
arterial dilation
2 uses for hydralazine?
CHF
HTN
3 uses for nitroprusside?
HTN emergencies
acute CHF
MI
2 AEs of nitroglycerin?
excessive hypotension
tolerance
3 AEs of hydralazine?
Fluid retention
tachy
Lupus-like rxn
order of strength of Ca blockers?
Verapamil > Diltiazem > Dihydropyridines
2 drugs to tx malignant HTN?
Minooxidil
Nitroprusside
