7. Vasodilators

Question 1

wc vasodilator has venodilation&raquo_space; artiodilation?

Answer 1

Nitroglycerin

Question 2

2 uses for PDE5 inhibitors?

suffix?

Answer 2

erectile dysfunciton
BPH

-afil

Question 3

4 AEs of ACE inhibitors?

Answer 3

tetratogenic
cough
hyperkalemia
hypersensitivity

Question 4

acute AE of nitroprusside?

chronic? symptoms

Answer 4

Hypotension

thiocyanate toxicity
- weakness, nausea, convulsions

Question 5

3 uses for Ca blockers?

Answer 5

Angina
Supraventricular tachyarrhythmias (verapamil)
HTN

Question 6

MOA of Aliskiren?

Answer 6

inhibits Renin

Question 7

3 guanylyl cyclase activators?

MOA?

Answer 7

Nitroprusside
Organic Nitrates
Hydralazine

inc cGMP –> vasodilation

Question 8

hw to treat respiratory failure in neonates with pulmonary hypertension?

Answer 8

Nitric oxide

Question 9

4 uses for ACE inhibitors?

Answer 9

hypertension
CHF
post MI
diabetic nephropathy

Question 10

3 effects of ACE inhibitors?

suffix?

Answer 10

dec TPR
dec Na and fluid retention
dec BP

-pril

Question 11

MOA of K channel openers?

Answer 11

increase K efflux at SM –> hyperpolarization –> relaxation –> dec TPR

Question 12

MOA of nitroprusside?

net effect?

Answer 12

arteriodilation = venodilation

dec. TPR, dec CO, dec BP, inc HR

Question 13

how are verapamil and diltiazem different from DHPs?

AEs?

Answer 13

V and D dec AV nodal conduction

Heart block

Question 14

MOA of Ca channel blockers?
effect?
phases affected?

Answer 14

inhibit L-type Ca channels

arteriodilation –> dec. TPR –> dec. BP

inhibit phase 0 depolarization in SA and AV nodes.
inhibit phase 2 of AP in muscle

Question 15

Name a K channel opener?

use?

Answer 15

Minoxidil

malignant HTN

Question 16

3 uses for nitroglycerin?

Answer 16

angina
CHF
Acute MI

Question 17

MOA of phosphodiesterase inhibitors?

name some

Answer 17

inhibit PDE type 5 –> potentiates NO –> inc cGMP

Question 18

MOA of hydralazine?

Answer 18

arterial dilation

Question 19

2 uses for hydralazine?

Answer 19

CHF

HTN

Question 20

3 uses for nitroprusside?

Answer 20

HTN emergencies
acute CHF
MI

Question 21

2 AEs of nitroglycerin?

Answer 21

excessive hypotension

tolerance

Question 22

3 AEs of hydralazine?

Answer 22

Fluid retention
tachy
Lupus-like rxn

Question 23

order of strength of Ca blockers?

Answer 23

Verapamil > Diltiazem > Dihydropyridines

Question 24

2 drugs to tx malignant HTN?

Answer 24

Minooxidil

Nitroprusside