29. Renal Vascular Disease Flashcards
df azotemia?
cause?
wt does it indicate?
elevated BUN and Creatinine
decreased GFR
renal disease
df uremia?
when renal failure causes clinical signs and symptoms
df diminished renal reserve?
renal insufficiency?
chronic renal failure?
end stage renal disease?
GFR 50% w no azotemia
GFR 20-50%
GFR <20%
GF<5%
pathogenesis of benign nephrosclerosis? (wt is deposited, wt vessels)
hw does kidney look?
hylaine deposition in arterioles
and medial and intimal thickening
normal to reduced size and surface is granular
wt causes malignant nephrosclerosis?
2 histo appearance?
hw does kidney look? (2 things)
malignant HTN
fibrinoid necrosis of arterioles
Onion-skin
flea-bitten appearance due to hemorrhages and swelling
wt causes renal artery stenosis?
unilateral constriction mostly due to atherosclerotic plaque occlusion –> renin release to increase BP –>contralateral kidney shows effects of HTN (arteriosclerosis
wt does renal artery stenosis resemble?
essential hypertension
pathogenesis of HUS?
endothelial injury –> platelet activation and thrombosis
cause of typical HUS?
shiga-toxin from E. coli 0157-H7 associated w contaminated food
cause of atypical HUS?
most common genetic cause?
Excessive activation of complement
Factor H deficiency
cause of thrombotic thrombocytopenic purpura? wt is deficient?
platelet aggregation from large multimers of vWF due to deficient ADAMTS13
pentad of TTP?
FAT RN Fever microangiopathic hemolytic Anemia Thrombocytopenia Renal failure Neuro symptoms
when do patients present with atheroembolic renal disease?
wt is seen histologically?
elderly patients following surgery
clefts of cholesterol
kidney vascular disease with fibroelastic hyperplasia?
benign nephrosclerosis
kidney vascular disease with hyperplastic ateriolosclerosis?
malignant nephrosclerosis
