1,4-5. Vascular Path,5 Flashcards
wt is the composition of a vulnerable atherosclerotic plaque?
thinner cap
large lipid core
arteries affected by giant cell vasculitis?
wt part of artery?
temporal, opthalmic
elastic intima
most common cause of thoracic aortic aneurysm?
HTN/cystic medial degeneration
pt presents with malignant hypertension,
underlying cause?
hyperplastic arteriolosclerosis
vasculitis with fragmentaiton of neutrophils
microscopic polyangiitis
2 symptoms of giant cell arteritis?
jaw claudicaiton
headache
2 asscoiationgs w aortic dissection?
HTN and inherited CT disorders
df true aneurysm?
abnormal dilation
wc vasculitis can cause blindness? why?
giant cell arteritis due to occlusion of the opthalmic artery
vasculitis associated with men who are heaving smokers?
wt in seen pathologically?
Buerger Disease (thromboangiitis obliterans)
Segmental thrombosis and microabsesses
wc vasculitis can cause renal microaneurysms?
wt is a unique GI symptom of this disease?
Polyarteritis nodosa
Melena (blood in GI tract –> black stool)
complication of kawasaki syndrome?
coronary aneurysms
most common cause of abdominal aortic aneurysm?
most common location?
presentation?
atherosclerosis
distal to renal arteries
pulsating abdominal mass
cause of false aneurysm?
defect in vascular wall –> hematoma
2 symptoms/signs of aortic dissection?
sudden chest pain radiating to back
unequal BP in arm
2 conditions associated with MPA-ANCA/p-ANCA?
Churg-Strauss
Microscopic polyangitis
df type A aortic dissection?
type B?
A - involves ascending aorta
B - descending aorta
4 arteries most affected by atherosclerosis?
AA > coronary > popliteal > internal carotid
4 modifiable risk factors for atherosclerosis?
hyperlipidemia
HTN
Cigs
DM
2 complications of aortic dissection rupture?
cardiac tamponade
hemothorax
2 types of ateriorolosclerosis?
wt causes each?
hyaline - mild, chronic htn
hyperplastic - malignant accelerated htn
condition associated with PR3-ANCA/c-ANCA?
Granulomatosis with polyangitis
steps to Intimal thickening?
SMCs migrate into intima and become proliferative (rather than contractile). they then synthesize ECM.
wt cells in the vasculature are responsible for synthesis of collagen, elastin and proteoglycans?
SMCs
wc vasculitis is known as the pulseless disease?
artery affected?
Takayasu vasculitis
Aortic arch
vasculitis associated with coronary artery aneurysoms?
Kawasaki
vasculitis associated with gangrene and amputation?
Buerger disease ( thromboangiitis obliterans)
cause of aortic dissection?
intimal tear –> false lumen
wt is the earliest lesion in atherosclerosis?
cell causing?
fatty streak
lipid-filled foamy macrophages
wc vasculitis has GI symptoms?
complication?
PAN
microaneurysm
vasculitis associated w palpable purpura?
microscopic polyangiitis
2 main strucutures of atherosclerotic plaques? components of each
Fibrous cap - SMCs, collagen
Lipid core - cholesterol, foam cells, necrotic debris, fibrin
wt ateries are affected by artiosclerosis?
elastic and muscular arteries
wc vasculitis is commonly seen in HepB pts?
Polyarteritis nodosa
Triad of polyangiitis with granulomatosis?
Respiratory involvement
focal necrotizing vasculitis of small vessels
renal disease
wt characterizes monckeberg arteriosclerosis?
ring like calcifications in media of muscular arteries
vasculitis seen in asian children <4 yo?
5 symotoms?
2 drugs to tx?
Kawasaki
Cunjunctival injection Rash Adenopathy Strawberry Tongue Hand-foot changes fever (CRASH and burn)
IV IGs and aspirin
4 presentations of Churg-strauss?
wt would be found in serum?
asthma, skin nodules, wrist/foot drop, eosinophilia
anti-meloperoxidase (MPA-ANCA/p-ANCA)
5 pathogenesis of aneurysims?
inflammaitn HTN atherosclerosis CT disorders Cystic medial degeneration
