12-13. Valvular Heart Disease Flashcards
condition causing mid systolic click?
Mitral valve prolapse
major criteria for acute rheumatic fever?
Joints (migratory arthritis) Carditis Nodules on skin (subcutaneous) Erythema marginatum Sydenham chorea
2 laboratory diagnosis of acute RF?
Steptolysin O antibody
DNAse B
most common complication of aRF? associated heart murmur?
Chronic Rheumatic Heart Disease
Mitral stenosis
organism causing acute endocarditis?
subacute?
virulence?
type of valves affected?
acute - S aureus (high virulence)
- normal valves
subacute - viridans streptococci (low virulence)
- abnormal valves
condition with vegetations most commonly on valves?
hw to diagnose?
infective endocarditis
Blood culture
symptoms of infective endocarditis?
Fever Roth Spots Osler nodes Murmur Janway lesions Anemia Nail-bed Hemorrhages Emboli
Complication of biopresthesis artificial valve?
mechanical valve?
bio - structural deterioration
mech - thromboembolic
2 cause of aortic stenosis?
wt happens to the heart in each
dystrophic calcificaiton due to age and CRF
ca- LV concentric hypertrophy
CRF - dilation
pts w what condition are at a really high risk of aortic stenosis?
characteristic of congenital cause?
acquired? wt causes acquired?
bicuspid valve
con - mitral valve is normal
acq - abnormal mitral valve, caused by rheumatic heart disease
2 morphologic characteristics of mitral valve prolase?
ballooning of leaflets
annular dilation
3 histo characteristics of mitral valve prolapse?
attenuation of collagenous fibrosa layer
thickening spongiosa
myomatous deposition in leaflets
symptoms of most mitral valvue prolapse?
4 complicaitons?
asymptomatice
infective endocarditis
arrhythmias
stroke from embolie
mitral insufficiency w chordae tendineae rupture
wt procederes rheumatic fever? location?
Strep A infection of pharyngitis
wt is seen microscopically in the heart during acute rhematic fever? 2 components?
Aschoff bodies
- T lymphocytes
- Anitschkow cells (plump macrophages)
wt is seen w endocarditis associated w Acute rheumatic fever?
fibrinoid necrosis
most frequent cause of mitral stenosis?
chronic rheumatic fever
most important consequence of acute RF?
chronic RHD
hw doe smitral valve look in chronic rheumatic fever?
fish mouth
agent causing infective endocarditis on prosthetic valves?
staph epidermidis
2 signs =/ symptoms of infective endocarditis?
fever
murmur
