20. HF Drugs

Question 1

Effect of Arteriodilation in CHF?

Answer 1

dec afterload –> inc. CO

Question 2

effect of venodilation in CHF?

Answer 2

dec preload –> dev LVEDV –> dec. congestion

Question 3

MOA of nitroprusside?

Answer 3

venodilation and arteriodilation

Question 4

MOA of hydralazine?

Answer 4

arteriodilation

Question 5

MOA of Organic Nitrates?

Answer 5

Venodilation > arteriodilation

Question 6

Combination of drugs used for CHF when ACEIs/ARBs are not tolerated?

Answer 6

Hydralazine + Organic Nitrate

Question 7

MOA of ACE inhibitors?

Answer 7

arteriodilation > venodilation

Question 8

MOA of AT Receptor antagonists?

Answer 8

arteriodilation > venodilation

Question 9

drug to tx acute decompensated CHF w dyspnea?

MOA?

Answer 9

Nesiritide

activates guanyl cyclase –> inc cGMP –> vasodilation

Question 10

MOA of phosphodiesterase inhibitors 3?

name of 1?

Answer 10

inc cAMP–> inc contractility + vasodilation

milrinone

Question 11

2 MOA of Digoxin?

Answer 11

inhibits Na-K ATPase –> inc Ca –> inc contractility

Vagomimetric –> dec automaticity

Question 12

4 AEs of Digoxin?

Answer 12

arrhythmias
GI
Visual
CNS

Question 13

pt is on vasodilator and presents with lupus like rxn, wt drug?

Answer 13

Hydralazine

Question 14

pt is on vasodilator and presents with weakness, nausea, and convulsions,
diagnosis?
drug?

Answer 14

cyanide toxicity

Nitroprusside

Question 15

2 side effects of phosphodiesterase inhibitors?

Answer 15

proarrhythmic

hypotension

Question 16

wt can nitroprusside tx?

Answer 16

acute (decompensated) CHF

Question 17

2 drugs 1st line tx for compensated HF?

Answer 17

ACEIs

b blockers

Question 18

HF drug used to tx A flutter/fib?

Answer 18

Digoxin

Question 19

HF patient presents w cough,

wt 2 classes of drugs can cause this?

Answer 19

ACEI

ARB

Question 20

drug only used for severe refractory HTN and malignant?

MOA?

Answer 20

minoxidil

K channel opener