7 Herpesvirus and Papillomavirus

Question 1

Herpes Virus:

1. Virus
2. Genome
3. Virion
4. Replication

Answer 1

1. Alphaherpesviridae
2. dsDNA
3. Enveloped
4. Short cycle, rapid spread, capacity to establish latency in sensory ganglia (triggered by sunburn, infections, stress)

Question 2

Alphaherpesvirus Disease:

1. Infection
2. Incubation
3. Symptoms
4. Prevention
5. Treatment

Answer 2

1. HSV-1: Oral-oral, oral-genital; HSV-2: Genital-genital, oral-genital
2. 2-14 days
3. Flu-like, localized lesions, mostly asymptomatic
4. Avoid contact
5. Acyclovir (limits replication)

Question 3

Betaherpesvirus Biology:

Replication:

Answer 3

Long reproductive cycle, slow progression, latent infection

Question 4

Beta/Gammaherpesvirus Biology:

1. Target
2. Prototypical member
3. Associated carcinomas
4. Persistence/Latency
5. Treatment/Prevention

Answer 4

1. T and B lymphocytes
2. Epstein-Barr virus (EBV)
3. Burkett’ Lymphoma, Hodgkin’s Lymphoma
4. CMV- hematopoietic Progenitor cells, macrophages; EBV- memory B Cells
5. Self limiting infections, antiviral therapy, immunoprophylaxis, no vaccines

Question 5

Human Papillomavirus Biology:

1. Virus
2. Genome
3. Virion
4. Proteins

Answer 5

1. Papillomaviridae
2. Circular dsDNA
3. Non-enveloped
4. L1- attachment; L2- penetration

Question 6

Human Papillomavirus Disease:

1. Infection
2. Symptoms
3. Prevention

Answer 6

1. Gain access through skin abrasion (skin-to-skin contact, fomites)
2. Site infection, warts, respiratory papillomatosis, oncogenesis (cervical cancer)
3. Ablative treatments, vaccination, no proof that condoms reduce risk