6 Respiratory Viruses

Question 1

Influenza Virus Biology:

1. Virus
2. Genome
3. Virion
4. Proteins
5. Replication

Answer 1

1. Orthomyxoviridae
2. 8 segments (-)ssRNA
3. Enveloped
4. HA-Hemagglutinin (cell attachment), NA- Neuraminidase (viral budding/release)
5. In nucleus (exception to “RNA replicates in cytoplasm” rule)

Question 2

___ is the major determinant in Avian vs. Human Influenza Strains as well as human to human transmission

Answer 2

HA (16 HA serotypes [surface antigens])

Question 3

Influenza Virus Disease:

1. Reservoir
2. Transmission
3. Incubation time
4. Contagious length
5. Prevention

Answer 3

1. Animals/birds
2. Aerosol (large/small droplets)
3. 1-4 days
4. Day before symptoms-5 days later (children longer)
5. Attenuated live vaccine (type A strain generated through reassortment via coinfection with PR8 strain); antivirals (blocks entry); tamiflu (zanamiver/oseltamivir)- blocks release of budding virions

Question 4

Avian Influenza:

1. Virus

Answer 4

1. H5N1

Question 5

Adenovirus Biology:

1. Virus
2. Genome
3. Virion
4. Replication

Answer 5

1. Adenoviridae
2. dsDNA
3. Non-enveloped
4. Entry via CAR, moves to nucleus

Question 6

Adenovirus Respiratory Disease:

1. ___ percent of viral infections
2. Symptoms

Answer 6

1. 5-10

2. Common cold, Acute Respiratory Disease (ARD)

Question 7

Rhinovirus Disease:

1. Reservoir
2. Incubation
3. Symptoms
4. Prevention

Answer 7

1. Humans
2. 1-4 days
3. Red nose, nasal discharge
4. No vaccines, no antivirals