2 Childhood Viral Diseases

Question 1

Measles Virus (Paramyxovirus) Biology:

1. Genome
2. Virion
3. Replication
4. Fusion protein causes

Answer 1

1. (-)ssRNA
2. Enveloped
3. Cytoplasm -> budding
4. Syncytia formation

Question 2

Measles the Disease:

1. Infection by?
2. Symptoms
3. Diagnosis
4. Prevention

Answer 2

1. Inhalation of aerosolized droplets -> respiratory epithelial tissues
2. Rash (koplik spots), most deadly childhood rash/fever illnesses, immune suppression, opportunistic infections, blindness in Vit A deficient kids, ADEM, SSPE
3. Koplik spots, ELISA, RT-PCR
4. Vaccination, Vitamin A (reduces severity), no antivirals

Question 3

Respiratory Syncytial Virus (RSV) is caused by ____ which makes it similar to ____. It specifically infects ____ cells in the respiratory tract epithelium. A common name for RSV is ____

Answer 3

Paramyxovirus

Measles

Ciliated cells

A cold

Question 4

Varicella Zoster Virus Biology:

1. Virus
2. Genome
3. Virion
4. Replication
5. Disease

Answer 4

1. Alphaherpesvirus
2. -> dsDNA, large
3. Enveloped
4. In nucleus (active cell); resting cell (neuron) -> latent infection (circular genome)
5. Chickenpox

Question 5

Chickenpox (VZV):

1. Infection
2. Symptoms
3. Prevention

Answer 5

1. Inhalation of aerosolized droplets
2. Fever, malaise, headache, rash, shingles (latent infection reactivated)
3. Vaccination, Antivirals (Acyclovir- blocks replication)

Question 6

Poliovirus Biology:

1. Virus
2. Genome
3. Virion
4. Replication
5. Disease

Answer 6

1. Picornavirus
2. (+)ssRNA
3. Non-enveloped
4. Creates pore in membrane, replicates in cytoplasm
5. Poliovirus

Question 7

Poliovirus the Disease:

1. Infection
2. Symptoms
3. Prevention

Answer 7

1. Fecal-oral transmission -> Replication in peyer’s patches of small intestine
2. Mild disease, CNS problems (rare) -> limb and respiratory paralysis
3. Vaccination- Salk (killed), Sabin (live); humans only reservoir

Question 8

Killed vaccines are going to get a good ____ response

Live vaccines get a good ____ response

Answer 8

Antibody-mediated

Cell-mediated

Question 9

Rotavirus Biology:

1. Virus
2. Genome
3. Virion
4. Replication
5. Disease

Answer 9

1. Reoviridae
2. dsRNA, 11 segments
3. Non-enveloped
4. Membrane disruption -> endocytosis -> replication in cytoplasm, genome never exposed
5. Rotavirus

Question 10

Rotavirus the Disease:

1. Infection
2. Symptoms
3. Diagnose
4. Prevention
5. Treatment

Answer 10

1. Ingestion
2. Vomiting, fever, diarrhea
3. Antigens in stool
4. Infant vaccines, no antivirals, hygiene
5. Oral rehydration