4 Neurological Viruses

Question 1

EEE and VEE Virus Biology:

1. Virus
2. Genome
3. Virion
4. Replication

Answer 1

1. Togaviridae
2. (+)ssRNA
3. Enveloped
4. Receptor-mediated endocytosis -> cytoplasm

Question 2

EEE and VEE virus Disease:

1. Infection
2. Incubation
3. Symptoms
4. Prevention

Answer 2

1. Infected arthropod bite -> lymph nodes -> CNS (possible)
2. 4-10 days
3. Systemic disease (fever, malaise…), Encephalitic disease (CNS probs)
4. Vaccine, no treatment, mosquito control

Question 3

West Nile Virus Disease:

1. Virus
2. Incubation
3. Symptoms
4. Prevention

Answer 3

1. Flaviviridae (same as HCV)
2. 2-14 days
3. Fever, neuroinvasive disease (rare)
4. None besides mosquito control

Question 4

Why is WNV way more widespread than EEE?

Answer 4

WNV has a broader host range (mosquitos) that fit more habitats

Question 5

Zika Virus:

1. Virus
2. Virion
3. Hosts
4. Symptoms

Answer 5

1. Flavivirus
2. Enveloped
3. Mosquitos, primates, rodents
4. Fever, Guillain-Barré syndrome, newborn microcephaly

Question 6

Rabies Virus Biology:

1. Virus
2. Genome
3. Virion
4. Replication

Answer 6

1. Rhabdoviridae
2. (-)ssRNA
3. Enveloped
4. Requires RNA-dependent RNA polymerase, in cytoplasm

Question 7

Rabies Virus Disease:

1. Transmission
2. Reservoir
3. Incubation
4. Symptoms
5. Prevention/Treatment

Answer 7

1. Bite of infected animal
2. Bats, skunks, raccoons, dogs, etc.
3. 1-3 months
4. Fever, hydrophobia (difficulty swallowing->foaming), cerebral dysfunction, probable death
5. Vaccine (animals too); Post-exposure prophylaxis (ASAP)