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Immunology > 7: Antibody Structure > Flashcards

7: Antibody Structure Flashcards

1
Q

Antibody

A

a multimeric protein produced and secreted by B cells

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2
Q

Each B cells produces __ antibody

A

one

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3
Q

4 main antibody functions

A
  1. opsonization
  2. ADCC
  3. complement activation
  4. neutralization
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4
Q

When is antibody production detectable after initial exposure?

A

3-7 days

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5
Q

What is the basic structure of an antibody?

A

2 light chains and 2 heavy chains

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6
Q

What subunit of an antibody determines Ig class?

A

heavy chain

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7
Q

What does the Fc portion contain?

A

heavy chain constant region

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8
Q

What does the Fab portion contain?

A

antigen binding site

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9
Q

T/F: Antibodies can bind to two of the same epitopes

A

T

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10
Q

How are the two antibody chains bonded?

A

non-covalently

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11
Q

Affinity

A

the measure of the strength of the interaction with one epitope

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12
Q

Avidity

A

the overall strength of the collective interactions; measure of affinity and valency

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13
Q

Valency

A

number of binding sites

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14
Q

What Ig isotypes always starts a sequence?

A

IgM and IgD

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15
Q

Idiotypic differences

A

difference in binding pocket, changes binding properties

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16
Q

Isotypic differences

A

difference in heavy chain, changes chemical properties

17
Q

What is the main function of IgE?

A

sensitization of mast cells

18
Q

What is the main function of IgM?

A

activates complement system

19
Q

What is the main function of IgG?

A

activates complement system, transports across placenta, diffusion into extravascular sites

20
Q

What is the main function of IgA?

A

transport across epithelium

21
Q

What Ig is most abundant in blood?

A

IgG

22
Q

What Ig is most abundant on mucosal surfaces?

A

IgA

23
Q

J chain

A

in B cells, linked with IgM pentamer and IgA dimer; used to transport dimeric IgA across epithelial barriers

Immunology (16 decks)

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