14: T Cell Activation (Cont.) Flashcards
1
Q
Perforin
A
polymerizes on cell membrane to form a pore
2
Q
Granzymes
A
serine proteases which cleave proteins on target cell membrane
3
Q
Lymphotoxin-alpha (LT-alpha)
A
induces cell death via apoptosis, a programmed cell death involving cleavage of genomic DNA
4
Q
What do CD8+ cell secrete?
A
IFN-alpha/beta
5
Q
What accounts for specificity of Tc cells?
A
polar release of cytolytic granules
6
Q
What is the advantage of apoptosis?
A
no trigger of inflammation
7
Q
Fas-FasL interactions induce what?
A
apoptosis
8
Q
Where does antigen recognition occur?
A
lymph node
9
Q
Where does clonal selection occur?
A
lymph node
10
Q
Where does the lethal hit occur?
A
peripheral tissues
11
Q
What is required to create and maintain memory CD8+ T cells?
A
CD4+ cells
