13: T Cell Activation

Question 1

What must happen for a naive T cell to become activated?

Answer 1

receive multiple signals from the APC

Question 2

Where does the initial interaction between T cells and Ag occur?

Answer 2

peripheral lymphoid organs

Question 3

How to T cells enter lymphoid tissue?

Answer 3

high endothelial venules

Question 4

Th cell polarization

Answer 4

When Th0 (naive CD4+ T) cells are activated, they further differentiate into types of Th cells

Question 5

Th1 cells

Answer 5

activate macrophages and amplify innate immune responses

Question 6

Th2 cells

Answer 6

activate mast cells, eosinophils, and B cells

Question 7

Th17 cells

Answer 7

activate neutrophils

Question 8

What cytokines activate to Th1?

Answer 8

IL-12 and IFN-gamma

Question 9

What cytokine activates to Th2?

Answer 9

IL-4

Question 10

What cytokines activate to Th17?

Answer 10

IL-6 and TGF-beta

Question 11

What cytokine activates to Treg?

Answer 11

TGF-beta

Question 12

Co-stimulatory molecules

Answer 12

where CD28 on T cells bind to on the APC to deliver a signal

Question 13

Tfh cells

Answer 13

activate and differentiate B cells