2: Tissues of the Immune System

Question 1

Primary organs

Answer 1

where leukocytes are differentiated from progenitor cells

Question 2

Primary organ examples

Answer 2

bone marrow, thymus, bursa, Peyer’s patches

Question 3

‘Secondary organs

Answer 3

sites where B and T cells are induced to function

Question 4

Secondary organ examples

Answer 4

lymph nodes, spleen, bone marrow, Peyer’s patches, tonsils

Question 5

Lymphoid organs

Answer 5

sites where lymphocytes develop and/or contact and respond to specific antigens

Question 6

What cells differentiate in the bone marrow or bursa?

Answer 6

B and T cells

Question 7

What cells differentiate in the thymus?

Answer 7

T cells

Question 8

What cells differentiate in Peyer’s patches?

Answer 8

B cells

Question 9

Peyer’s patches

Answer 9

organized tissues in lower GI tract

Question 10

Stromal cells

Answer 10

support lymphopoiesis and myelopoiesis via both surface ligands and secretion of cytokines/growth factors

Question 11

Interleukin 7

Answer 11

key cytokine that signals a B cell to be made

Question 12

Where does blood formation occur in neonates who have not yet fully developed bone marrow?

Answer 12

spleen, liver, and lymph nodes

Question 13

Terminal differentiation

Answer 13

presentation of self antigens drives T cells maturation

Question 14

Tolerance

Answer 14

process that keeps you from attacking your own tissues as foreign

Question 15

Hassall’s corpuscle

Answer 15

concentric epithelial cells that have a role in tolerance

Question 16

Cortex

Answer 16

densely packed with immature T cells and B cells

Question 17

Medulla

Answer 17

less dense collection of mature lymphocytes (plasma cells)

Question 18

Trabuculae

Answer 18

divide the thymus into lobes

Question 19

The ____ shrinks in size after sexual maturity

Answer 19

thymus

Question 20

How are Peyer’s patches arranged

Answer 20

in follicles, with B cells central and T cells surrounding

Question 21

What animals are Peyer’s patches more prominent in?

Answer 21

ruminants

Question 22

3 main components of lymph nodes

Answer 22

1. cortex
2. medulla
3. germinal center

Question 23

Germinal center

Answer 23

site of B cell proliferation and activation

Question 24

High endothelial venules (HEV)

Answer 24

where lymphocytes pass through to migrate into the lymph-node parenchyma, lack tight junctions

Question 25

What is the largest lymphoid organ?

Answer 25

spleen

Question 26

Primary purpose of spleen

Answer 26

storage and filtration of RBC

Question 27

Red pulp of spleen

Answer 27

contains phagocytes

Question 28

White pulp of spleen

Answer 28

contains lymphocytes, mostly B cells but also some T cells

Question 29

Species that use spleen and liver as primary response to blood-borne pathogens?

Answer 29

rabbit, dog, mouse

Question 30

Species that use lungs as primary response to blood-borne pathogens?

Answer 30

cat, calf, sheep

Question 31

MALT

Answer 31

mucosa-associated lymphoid tissue

Question 32

GALT

Answer 32

gut-associated lymphoid tissue

Question 33

BALT

Answer 33

bronchus-associated lymphoid tissue