16: Mucosal Immunity Flashcards
What are the junctions between mucosal epithelial cells?
tight junction
IEL
intraepithelial lymphocyte
What do goblet cells produce?
mucins
What is the main isotype in the lower respiratory tract and genitalia?
IgG
What is the main isotype in the upper respiratory tract?
IgA
What lamellar bodies secrete?
defensins and cathelicidins
Which T cells live within the epideris?
CD8+ memory T cells
Which T cells live within the dermis?
CD4+ Trm cells
What is the function of Paneth cells?
secrete defensins and antimicrobial peptides
What are commensals typically resistant to?
defensins and IgA
What is transcytosis of IgA mediated by?
polyIg receptor
Abs for immune exclusion
IgA, IgM
Abs for immune elimination
IgE, IgG, IgM
M cells
act as regulated gates in epithelial barriers
Which T cells are more prominent in lamina propria lymphpcytes?
CD4+ and Treg cells