12: T Cell Receptors

Question 1

Cytotoxic T cells

Answer 1

CD8+ cells that target cells infected with viruses or antigens bound to MHC class I

Question 2

Helper T cells

Answer 2

CD4+ cells that activate macrophages, B cells, or neutrophils

Question 3

Regulatory T cells

Answer 3

block activation of other T cells

Question 4

How do T cell receptors generate diversity?

Answer 4

somatic recombination of germline DNA

Question 5

T/F: TCR are secreted from the T cell

Answer 5

F

Question 6

CD3

Answer 6

multi-subunit complex that is associated with TCRs and transmits intracellular signals

Question 7

How do T cells receptors create identical specificity?

Answer 7

allelic exclusion

Question 8

Where does TCR gene rearrangement occur?

Answer 8

thymus

Question 9

What do B cell receptors do that T cell receptors don’t?

Answer 9

1. somatic hypermutation
2. secreted from cell

Question 10

T/F: T cells are antigen-specific

Answer 10

F

Question 11

Positive selection

Answer 11

CD8+ or CD4+ T cells will not be selected for without the antigen presentation by MHC class I and II molecules

Question 12

What happens to non-functional T cells?

Answer 12

apoptosis

Question 13

Which chain rearranges first?

Answer 13

beta

Question 14

Which chain rearranges second?

Answer 14

alpha